Clinical Trial Search

Primary: Summary of Change From Baseline in Total Sum of McGill Pain Questionnaire to Visit 3 — -14.48 Scores on scale

Primary: International Restless Legs Syndrome Rating Scale (IRLS) Total Score — -11.6; -14.3; -14.6 Scores on a scale

Primary: Change From Baseline in International Restless Legs Syndrome Rating Scale (IRLS) Score at Week 12 — -10.5; -11.7 units on a scale — p=0.088

Primary: Frequency Analysis for Baseline Pattern of RLS Symptoms — 0.7; 2.4; 19.3; 18.1 percentage of participants

Primary: Change in Restless Legs Syndrome Rating Scale — -5.0; -1.0; -2.7; -5.0 RLS Rating Score

Primary: The Change From Baseline to Week 6 in the Total Score of Restless Legs Syndrome Rating Scale for Severity of the International Restless Legs Syndrome Study Group (IRLS)…

Primary: Change From Baseline in IRLS Rating Scale Total Score at Week 12 Using Last Observation Carried Forward (LOCF) — -9.8; -13.0 scores on a scale — p=0.0015

Primary: Change From Baseline in the Number of Elevations of Systolic Blood Pressure (BP) During the Night That Are Associated With Periodic Limb Movements (PLMs) at the End of…

Primary: Average Change of the MADRS (Montgomery-Asberg Depression Rating Scale) Total Score From Baseline to Final Visit After 12 Weeks of Treatment — -10.1; -6.5 Score on a…

Primary: Change From Baseline in the International Restless Legs Syndrome Rating Scale (IRLS) at Week 52 Using Observed Case (OC) — -16.3; -17.0; -16.8 points on a scale

Primary: International Restless Legs Syndrome (IRLS) Total Score — -8.9; -4.0 Scores on a scale

Primary: Number of Subjects Withdrawn Due to An Adverse Event (AE) From Visit 1 (Day 1) Through End of Study — 3 subjects

Primary: The Incidence and Severity of Adverse Events (AEs), Vital Signs, and Laboratory Parameters — 175; 139; 5; 1 participants

Primary: Severity of Restless Legs Syndrome (RLS) at Bedtime — -2.2; 5.2 units on a scale

Primary: Mean Css, Max and Css, Min — 3.86; 7.14; 11.4; 14.0 nanograms per milliliter (ng/ml)