Clinical Trial Search

Primary: Percentage of Subjects With ≥2-Grade Improvement From Baseline on Both the Investigator's and Subject's Facial Wrinkle Scale (FWS) Ratings of Forehead Line Severity at…

Primary: Changes to the Surface by Visual and Photographic Analysis. — 41 participants

Primary: Fitzpatrick Classification of Wrinkling and Degree of Elastosis. — 5.6; 5.56; 5.36; 5.32 Fitzpatrick Classification Scale

Primary: Inter-rater Reliability of Assessment of Facial Lines Using the 4-Point Facial Wrinkle Scale (FWS-A) — 0.653; 0.637; 0.647; 0.654 Kappa statistics

Primary: Percentage of Participants Satisfied With Treatment of Glabellar Lines Assessed Using the Facial Line Satisfaction Questionnaire (FLSQ) — 81.7; 0.0 Percentage of…

Primary: Independent Photo Reviewer Fitzpatrick Wrinkle and Elastosis Scale (FWS) — 55 Participants — p=<.0001

Primary: Percentage of Subjects With ≥2-Grade Improvement From Baseline on Both the Investigator's and Subject's Facial Wrinkle Scale (FWS) Ratings of Forehead Line Severity at…

Primary: Change From Baseline in Perioral Rhytids Severity Rating Scale (PR-SRS) Score Rated by the Blinded Live Evaluator (BLE) at Week 8 After Last Treatment. — 121; 4; 29; 47…

Primary: Number of Subjects With Naturalness of Expression in Motion (2D Video) — 30 Participants

Primary: Number of Genes Upregulated or Downregulated as Assessed by RNA Sequencing (Older Group, Retinol Versus Placebo) — 23; 21 genes

Primary: Photographic Knee Laxity and Texture Evaluation — 1.87; 2.02 score on a scale

Primary: Local and Systemic Adverse Events — 100 percentage of participants

Primary: Analysis of Elasticity (Collagen & Elastin) — 1.7; 0.5; 1.5; 0.5 units on a scale

Primary: Non-inferiority of the Delta of TEOSYAL® RHA GA and TEOSYAL® RHA DL Versus Juvéderm® Ultra XC for the Correction of Moderate to Severe NLFs Based on the Wrinkle Severity…

Primary: Skin Aging Measured With the Photonumeric Scale. — 21.25; 21.36; 21.21; 21.03 Units on a scale

Primary: Posttreament Results of Chemical Peel if Botox A is Added as Pre-treatment — 1; 2 Units on a wrinkle severity scale — p=.002

Primary: Change in Neck and Facial Wrinkles Using the Fitzpatrick Wrinkle Assessment — 74 percentage of participants

Primary: Change From Baseline in Overall Photodamage Score — 5.6; -0.8 score on a scale — p=<0.001

Primary: Change From Baseline in Ra (a dermaTOP Parameter), of Test Product Treated Versus (vs.) Untreated Side at Day 29 — -1.90; -0.12 Micro meter (µm) — p=0.0638

Primary: Subject Satisfaction — 2.8 score on a scale

Primary: Day 180 Number of Participants With Improvement Measured By Independent Photographic Review — 6; 52 Participants — p=<0.0001

Primary: Percent Change From Baseline in Microtopographic Profilometry Ra Values (Skin Roughness). — 3.62; 18.57 Percent change post-treatment — p=<0.0001

Primary: Overall Improvement in Periorbital Wrinkles and Rhytids Around the Eyes — 47; 50 percentage of participants improved

Primary: Percentage of Participants (Responders) With At Least 1-Point Improvement From Baseline on the GCRS, as Assessed by the Blinded Evaluator at Month 6 ([Baseline…

Primary: Non-inferiority of RHA® Redensity With New Anesthetic Agent Versus RHA® Redensity With Lidocaine in Terms of Reducing Pain During Device Injection Into the Upper…

Primary: Percentage of Treated Subjects With Improvement in Lines and Wrinkles of the Décolleté at Day 90 — 62.2 percentage of subjects

Primary: Percentage of Responders Based on Composite Facial Wrinkle Scale Assessment of Crow's Feet Line Severity at Maximum Smile — 21.3; 20.6; 0.0 Percentage of participants

Primary: Percentage of Responders, Defined by at Least 1-point Improvement From Baseline on the WSRS. — 72.9; 72.8 percentage of subjects

Primary: Number of Participants With Effectiveness and Safety Success — 30; 41 participants

Primary: Non-inferiority of the Delta of the WSRS Score Between W24 and Baseline for TEOSYAL® RHA Ultra Deep Versus Perlane-L® for the Correction of Moderate to Severe…