Phase 2 N=43 Anti-Inflammatory Agent in Sinusitis
Nasal Polyps
Primary: TOTAL POLYP SCORE (TPS) — 4.67; 5.24 units on a scale — p=<0.05
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 2 N=16 Nasally Delivered Pulmozyme for Sinusitis in Cystic Fibrosis
Sinusitis · Cystic Fibrosis
Primary: Computed Tomography Evidence of Less Sinus Disease — 5.875; 3 units on a scale — p=0.2
Phase 3 N=386 Efficacy and Safety of a Herbal Medicinal Product (Dry Extract BNO 1016) in Patients With Acute Rhinosinusitis
Acute Rhinosinusitis
Primary: Major Symptom Score (MSS) Assessed by the Investigator — 2.38; 3.41 units on a scale
Phase 4 N=49 Sinuclean's Treatment Of Sinusitis' Symptoms
Sinusitis
Primary: Presence of Mucus in the Paranasal Sinuses (Outcome Measure Percentage of Patients) — 71; 57; 33 percentage of patients — p=<0.05
Phase 4 N=53 Effectiveness of Mometasone Nasal Irrigation for Chronic Rhinosinusitis
Chronic Rhinosinusitis (Diagnosis) · Allergic Rhinosinusitis · Chronic Eosinophilic Rhinosinusitis
Primary: Change in Sino-Nasal Outcome Test Scores (SNOT-22) — 23.18; 17.7 score on a scale
Phase 2 N=19 Buparid/PARI SINUS Versus Budes® Nasal Spray in the Therapy of Chronic Rhinosinusitis
Rhinosinusitis
Primary: Change of Inflammation of the Nasal Mucosa and Paranasal Sinus — 0; -0.8 score on a scale
Phase 4 N=68 The Use of Antibiotic Sinonasal Rinse After Sinus Surgery
Chronic Rhinosinusitis
Primary: Quality of Life in Chronic Rhinosinusitis Patients — 23; 21 Units on a scale
Phase 3 N=25 Oral Versus Topical Antibiotics for Chronic Rhinosinusitis Exacerbations
Chronic Rhinosinusitis
Primary: Change in Rhinosinusitis Disability Index (RSDI) Score — -8.000; -14.82 units on a scale — p=0.505
Phase 4 N=77 Use of Probiotics as Adjunctive Treatment for Chronic Rhinosinusitis
Chronic Rhinosinusitis
Primary: Mean Reduction in SNOT-20 Scores — 1.8; 5.5 units on a scale — p=0.23
Phase 1 N=16 Potential for Cortisol Suppression With the Use of High Volume Nasal Mometasone Irrigations in Varying Dosages.
Chronic Rhinosinusitis (Diagnosis)
Primary: Morning "AM" Serum Cortisol Level — 17.35; 14.48 mcg/dL
Phase 4 N=166 Treatment of Acute Sinusitis
Acute Respiratory Infections · Acute Rhinosinusitis
Primary: SNOT-16 Score (Sino-Nasal Outcomes Test) at Day 3 — 1.12; 1.14 Units on a scale — p=0.83
Phase 2 N=20 Study of Dexpramipexole Chronic Sinusitis With Nasal Polyps and Eosinophilia
Chronic Sinusitis With Nasal Polyps and Eosinophilia
Primary: Ratio to Baseline in Peripheral Blood Eosinophil Counts After 6 Months of Treatment — 0.06 ratio to baseline — p=< 0.001
N/A N=82 Trans-Nasal Maxillary Multi-Sinus Balloon Dilation Study
Sinusitis
Primary: Change in SNOT-20 Score — 2.3; 0.7 score on a scale — p=<0.0001
Phase 2 N=24 Benralizumab Effect on Severe Chronic Rhinosinusitis With Eosinophilic Polyposis
Chronic Rhinosinusitis (Diagnosis) · Nasal Polyps · Eosinophilia
Primary: Change in Nasal Polyp Score — .9; .3 score on a scale
Phase 4 N=39 Allergic Rhinitis Changes the Sinus Microbiome
Seasonal Allergic Rhinitis
Primary: Total Nasal Symptom Score (TNSS) — 67.1; 78.0 score on a scale — p=0.391
Phase 4 N=80 The Impact Of The Addition Of Budesonide To Low-Pressure, High-Volume Saline Sinus Irrigation For Chronic Rhinosinusitis
Rhinosinusitis · Chronic Eosinophilic Rhinosinusitis · Allergic Rhinosinusitis
Primary: Change in SNOT-22 (Sino-Nasal Outcome Test) — 20.7; 13.6 score on a scale
N/A N=37 The Efficacy of MEDIHONEY® for Chronic Rhinosinusitis With Nasal Polyposis After Functional Endoscopic Sinus Surgery
Chronic Sinusitis · Nasal Polyposis
Primary: Change in Lund-Kennedy Endoscopic Scores — -8.0; -1.5; -6.9 score on a scale
N/A N=40 Comparing the Use of Saline or Saline Plus Gentamycin in Nasal Irrigation to Treat Chronic Sinusitis in Children
Sinusitis
Primary: Change in Computed Tomography (CT) Score After Treatment — -.64; -.63; -.5; -.5 units on a scale
Phase 2 N=22 The Effectiveness of Topical Silver Colloid in Treating Patients With Recalcitrant Chronic Rhinosinusitis
Rhinosinusitis
Primary: Change in Sino-nasal Outcome Test-22 Score Between Baseline and 6 Weeks, Then 6 Weeks to 12 Weeks. — 59.3; 52.9; 45.4; 51.8 units on a scale
N/A N=80 Effect of Squeezable Bottle Nasal Irrigation Device in Children With Sinusitis
Sinusitis
Primary: the Effect of Squeezable Bottle and Syringe on Clinical Effectiveness in Sinusitis Children — 6.56; 6.89; 2.17; 1.24 units on a scale — p=<0.05
Phase 2 N=14 Buparid/PARI SINUS Versus Budes® Nasal Spray in the Therapy of Chronic Rhinosinusitis With Polyposis Nasi
Rhinosinusitis · Chronic Polyposis
Primary: Change of Inflammation of the Nasal Mucosa and Paranasal Sinus — -2; -0.8 units on a scale
N/A N=25 Study for the Management of Pediatric Chronic Rhinosinusitis With or Without Balloon Sinuplasty
Rhinitis + Sinusitis, Pediatric Chronic Rhinosinusitis
Primary: Quality of Life (QoL) Outcomes Between Adenoidectomy + Maxillary Sinus Irrigation With or Without the Use of Balloon Dilation or Maxillary Sinus Ostia. — 2.48; 2.5…
Phase 2 N=741 Dose Finding Study of Fluticasone Furoate Nasal Spray for Uncomplicated Acute Rhinosinusitis
Sinusitis, Acute
Primary: Mean Change From Baseline in the Daily Major Symptom Score (MSS) Over the Entire Treatment Period (Weeks 1-2) — -2.97; -3.36; -3.33 units on a scale — p=0.008
Phase 3 N=300 S8 Sinus Implant in Chronic Sinusitis Patients With Recurrent Nasal Polyps
Chronic Sinusitis · Nasal Polyposis
Primary: Nasal Obstruction/Congestion Score — 2.36; 2.35; 1.56; 1.79 units on a scale — p=0.0074
N/A N=50 Clinical Evaluation of the Steroid-Eluting Sinexus Intranasal Splint When Used Following Functional Endoscopic Sinus Surgery (FESS) in Patients With Chronic Sinusitis
Chronic Sinusitis
Primary: Safety as Determined by the Frequency of Serious Adverse Local Tissue Response (SALT) — 6 Number of Sinuses
N/A N=14 Study to Evaluate the Safety and Initial Effectiveness of the Sinusway™ for Endoscopy of Sinuses in Conjunction With BSD
Sinusitis
Primary: Number of Adverse Device Effects — 0 events
Phase 3 N=196 Efficacy and Safety of LYR-210 for the Treatment of Chronic Rhinosinusitis in Adults
Chronic Sinusitis · Chronic Rhinosinusitis (Diagnosis)
Primary: Change From Baseline (CFBL) in the 7-day Average Composite Score of 3 Cardinal Symptoms (3CS) in Participants Without Nasal Polyps. — -2.13; -2.06 score on a scale
Phase 3 N=944 Efficacy and Safety of Acetylcysteine for the Treatment of Acute Uncomplicated Rhinosinusitis
Rhinosinusitis
Primary: Mean Change From Baseline in the Daily Major Symptom Score (MSS) Over the Entire Treatment Period, Full Analysis Set — -4.8213; -4.7394; -4.7758; -5.0180 Score on a scale
Phase 2 N=60 An Evaluation of Dupilumab in Patients With Nasal Polyposis And Chronic Symptoms Of Sinusitis
Nasal Polyps
Primary: Change From Baseline in Bilateral Endoscopic Nasal Polyp Score (NPS) at Week 16 — 5.67; 5.87; 5.39; 3.97 score on a scale — p=0.0009
Phase 3 N=408 Efficacy and Safety of Tezepelumab in Participants With Severe Chronic Rhinosinusitis With Nasal Polyposis
Chronic Rhinosinusitis With Nasal Polyps
Primary: Change From Baseline in Total Nasal Polyp Score at Week 52 — -2.458; -0.380 Score — p=<.0001