Trials: Stenosis

N/A N=196 Efficacy of Acupuncture for Lumbar Spinal Stenosis

Lumbar Spinal Stenosis · Intermittent Claudication

Primary: The Change in Modified Roland-Morris Disability Questionnaire (RMDQ) Score From Baseline — -4.3; -3.0 score on a scale

Guang'anmen Hospital of China Academy of Chinese… Results Aug 2025 2.0% serious AE View details

Phase 4 N=29 Lumbar Stenosis Outcomes Research (LUSTOR)

Lumbar Spinal Stenosis

Primary: Time to First Symptoms of Moderate Pain — 2.52; 3.06 minutes

University of Rochester Results Jun 2016 0.0% serious AE View details

N/A N=655 Aortoiliac Stenosis in Kidney Transplantation

Aorto-Iliac Arterial Stenosis · Peripheral Arterial Disease · Kidney Transplant Failure

Primary: Patient Survival — 322; 48; 6 Participants

Erasmus Medical Center Results Dec 2024 0.0% serious AE View details

N/A N=100 Sagittal Plane Shear Index for Planning Lumbar Stenosis Surgery

Lumbar Spinal Stenosis · Spondylolisthesis

Primary: Proportion of Surgical Plans Recorded Prior to the SPSI Report That Are Altered After Integration of SPSI Into the Surgical Planning — 47; 22; 6 Surgical plans

Medical Metrics Diagnostics, Inc Results Jul 2024 34.7% serious AE View details

N/A N=391 Investigating Superion™ In Spinal Stenosis

Lumbar Spinal Stenosis · Intermittent Claudication

Primary: Percentage of Subjects With Clinically Significant Improvement in Outcomes — 52.7; 50.2 percentage of subjects

Boston Scientific Corporation Results Aug 2020 58.8% serious AE View details

N/A N=105 Coarctation Of the Aorta Stent Trial

Coarctation of the Aorta

Primary: Change in Difference Between Arm and Leg Systolic Blood Pressure From Baseline to 12 Months — 30 mmHg

Richard E. Ringel Results Sep 2014 1.0% serious AE View details

Phase 3 N=451 Stenting vs. Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis

Ischemic Stroke

Primary: Any Stroke or Death Within 30 Days of Enrollment or Any Revascularization Procedure OR an Ischemic Stroke in the Territory of the Symptomatic Intracranial Artery Beyond…

Medical University of South Carolina Results Jul 2014 59.2% serious AE View details

Phase 4 N=400 Lumbar Epidural Steroid Injections for Spinal Stenosis Multicenter Randomized, Controlled Trial (LESS Trial)

Spinal Stenosis · Low Back Pain

Primary: Roland Morris — 11.8; 12.5 units on a scale

University of Washington Results Dec 2017 2.3% serious AE View details

N/A N=146 Prevalence of Renal Artery Stenosis in Patients Referred for Cardiac Catheterization

Renal Artery Stenosis

Primary: Prevalence of Renal Artery Stenosis (RAS)

Imam Khomeini Hospital Results Mar 2010 0.0% serious AE View details

Phase 4 N=55 MiDAS II (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study

Lumbar Spinal Stenosis

Primary: Changes in Back Pain as Measured by a 10-point Visual Analog Scale (VAS). — 3.59 units on a scale — p=<0.0001

Vertos Medical, Inc. Results Apr 2013 0.0% serious AE View details

N/A N=69 Long-Term Outcomes for Lumbar Spinal Stenosis Patients Treated With X STOP®

Lumbar Spinal Stenosis

Primary: Treatment Success Rates (At ≥ 5 Years) — 40.8; 30.8; 38.7; 53.8 percentage of participants

Medtronic Spine LLC Results Jul 2011 21.7% serious AE View details

N/A N=259 Study Comparing 3 Different Treatments for Arthritis of the Lower Back (Lumbar Spinal Stenosis)

Lumbar Spinal Stenosis

Primary: Swiss Spinal Stenosis (SSS) Questionnaire Score — -2.0; -1.7; -4.1 units on a scale — p=0.73

Michael Schneider, DC, PhD Results May 2017 0.0% serious AE View details

Phase 2 N=82 Covered CP Stents for the Prevention or Treatment of Aortic Wall Injury Associated With Coarctation of the Aorta

Aortic Coarctation

Primary: Study Participants With Grade 4 or 5 in Degree of Aortic Wall Injury (AWI) and/or Aortic Arch Obstruction Without Clinical Worsening — 55 participants

Johns Hopkins University Results Mar 2016 1.2% serious AE View details

N/A N=68 Renal Stent Placement for the Treatment of Renal Artery Stenosis in Patients With Resistant Hypertension

Renal Artery Stenosis · Hypertension, Renovascular

Primary: Primary Patency — 66 Subject-lesions — p=<.0001

Atrium Medical Corporation Results Aug 2019 58.8% serious AE View details

Phase 3 N=1,873 An Investigational Drug on Clinical Outcomes in Patients With Aortic Stenosis (Narrowing of the Major Blood Vessel of the Heart)(MK-0653A-043 AM4)(COMPLETED)

Aortic Stenosis

Primary: Number of Participants That Experienced One or More Components of the Composite Clinical Endpoint of MCE (Major Cardiovascular Events) — 333; 355 Participants — p=0.591

Organon and Co Results May 2009 View details

Phase 4 N=162 Intermittent Neurogenic Claudication Treatment With APERIUS®

Spinal Stenosis

Primary: Mean Percentage Change in Symptom Severity at 6 Weeks Compared to Baseline, Using the Patient Completed Zurich Claudication Questionnaire for Symptom Severity — -29.7…

Medtronic Spinal and Biologics Results Aug 2011 24.8% serious AE View details

N/A N=302 The MiDAS ENCORE Study

Spinal Stenosis, Lumbar Region, With Neurogenic Claudication

Primary: Number of Participants Who Achieved a Clinically Significant Improvement in the Oswestry Disability Index at 12 Months — 83; 35 Participants

Vertos Medical, Inc. Results Jul 2017 10.3% serious AE View details

Phase 4 N=38 Study of Epidural Steroid Injection (ESI) Versus Minimally Invasive Lumbar Decompression (Mild®) in Patients With Symptomatic Lumbar Central Canal Stenosis

Lumbar Spinal Stenosis

Primary: Mean Change in VAS — 2.52; 0.06 units on a scale — p=<0.05

Coastal Orthopedics & Sports Medicine Results Nov 2013 0.0% serious AE View details

Phase 3 N=947 Benefits of Medical Therapy Plus Stenting for Renal Atherosclerotic Lesions

Atherosclerosis · Cardiovascular Diseases · Hypertension, Renovascular

Primary: Composite Endpoint: Death From Cardiovascular or Renal Causes, Stroke, Myocardial Infarction, Hospitalization for CHF, Progressive Renal Insufficiency, or Permanent…

Baim Institute for Clinical Research Results Jan 2014 61.6% serious AE View details

N/A N=390 A Pivotal Study of a Facet Replacement System to Treat Spinal Stenosis

Lumbar Spinal Stenosis

Primary: Measure of Pain/Disability Using the Zurich Claudication Questionnaire (ZCQ) Physical Function Score — 1.7; 1.6; 1.7 score on a scale

Globus Medical Inc Results Sep 2020 44.0% serious AE View details

N/A N=138 MiDAS III (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study

Lumbar Spinal Stenosis

Primary: Percentage of Participants With a 2-point Improvement in Visual Analogue Scale — 65.71; 46.15 percentage of responders

Vertos Medical, Inc. Results Aug 2015 4.4% serious AE View details

N/A N=29 JetStream (JS) Atherectomy in Femoropopliteal In-Stent Restenotic Lesions

Restenosis · Peripheral Vascular Disease

Primary: Acute Procedural Success — 29 limbs

Midwest Cardiovascular Research Foundation Results May 2017 13.8% serious AE View details

N/A N=141 Iliac Artery Treatment With The Invatec Scuba™ Cobalt Chromium Stent (INTENSE)

Peripheral Artery Disease

Primary: Composite of Major Adverse Events (MAE) Defined as the Occurrence of In-hospital Myocardial Infarction (MI) or Target Segment Revascularization, Target Limb Loss, or…

Medtronic Endovascular Results Jun 2013 33.3% serious AE View details

N/A N=239 Clinical Trial Comparing Decompression With and Without Coflex™ Interlaminar Technology Treating Lumbar Spinal Stenosis

Spinal Stenosis

Primary: Change in ODI From Baseline to 24 Months — -19.0; -22.5 percentage points

Paradigm Spine Results Jun 2020 77.4% serious AE View details

N/A N=168 The STEPS - Totalis™ Trial

Lumbar Spinal Stenosis

Primary: Percentage of Subjects With Clinically Significant Improvement in Outcomes — 56.3; 56.0 percentage of subjects

VertiFlex, Incorporated Results Aug 2020 17.9% serious AE View details

Phase 4 N=78 MiDAS I (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study

Lumbar Spinal Stenosis

Primary: Mean Change in Back Pain as Measured by a 10-point Visual Analog Scale (VAS). — 3.21 units on a scale — p=<0.0001

Vertos Medical, Inc. Results Apr 2013 0.0% serious AE View details

Phase 3 N=70 Safety Study to Lower the Risk of Heart Failure is Also Effective in Reducing Stiffness of the Arteries

Hypertension · Diabetes

Primary: Change in Central Systolic Blood Pressure (SBP) — 125.3; 127.8; 121.6; 123.8 mmHg

University of Chicago Results Nov 2014 0.0% serious AE View details

N/A N=50 Pulmonary Artery Repair With Covered Stents

Pulmonary Stenosis · Pulmonary Regurgitation · Tetralogy of Fallot

Primary: Successful Repair of Conduit Disruption — 48 participants

Johns Hopkins University Results Mar 2016 2.0% serious AE View details

N/A N=275 FLUENCY® PLUS Endovascular Stent Graft for In-stent Restenosis

Restenosis

Primary: Percentage of Participants With Access Circuit Primary Patency (ACPP) That is Superior for FLUENCY® PLUS Endovascular Stent Graft (Following Percutaneous Transluminal…

C. R. Bard Results Jan 2017 3.0% serious AE View details

Clinical Trial Search

N/A N=196 Efficacy of Acupuncture for Lumbar Spinal Stenosis

Phase 4 N=29 Lumbar Stenosis Outcomes Research (LUSTOR)

N/A N=655 Aortoiliac Stenosis in Kidney Transplantation

N/A N=100 Sagittal Plane Shear Index for Planning Lumbar Stenosis Surgery

N/A N=391 Investigating Superion™ In Spinal Stenosis

N/A N=105 Coarctation Of the Aorta Stent Trial

Phase 3 N=451 Stenting vs. Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis

Phase 4 N=400 Lumbar Epidural Steroid Injections for Spinal Stenosis Multicenter Randomized, Controlled Trial (LESS Trial)

N/A N=146 Prevalence of Renal Artery Stenosis in Patients Referred for Cardiac Catheterization

Phase 4 N=55 MiDAS II (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study

N/A N=69 Long-Term Outcomes for Lumbar Spinal Stenosis Patients Treated With X STOP®

N/A N=259 Study Comparing 3 Different Treatments for Arthritis of the Lower Back (Lumbar Spinal Stenosis)

Phase 2 N=82 Covered CP Stents for the Prevention or Treatment of Aortic Wall Injury Associated With Coarctation of the Aorta

N/A N=68 Renal Stent Placement for the Treatment of Renal Artery Stenosis in Patients With Resistant Hypertension

Phase 3 N=1,873 An Investigational Drug on Clinical Outcomes in Patients With Aortic Stenosis (Narrowing of the Major Blood Vessel of the Heart)(MK-0653A-043 AM4)(COMPLETED)

Phase 4 N=162 Intermittent Neurogenic Claudication Treatment With APERIUS®

N/A N=302 The MiDAS ENCORE Study

Phase 4 N=38 Study of Epidural Steroid Injection (ESI) Versus Minimally Invasive Lumbar Decompression (Mild®) in Patients With Symptomatic Lumbar Central Canal Stenosis

Phase 3 N=947 Benefits of Medical Therapy Plus Stenting for Renal Atherosclerotic Lesions

N/A N=390 A Pivotal Study of a Facet Replacement System to Treat Spinal Stenosis

N/A N=138 MiDAS III (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study

N/A N=29 JetStream (JS) Atherectomy in Femoropopliteal In-Stent Restenotic Lesions

N/A N=141 Iliac Artery Treatment With The Invatec Scuba™ Cobalt Chromium Stent (INTENSE)

N/A N=239 Clinical Trial Comparing Decompression With and Without Coflex™ Interlaminar Technology Treating Lumbar Spinal Stenosis

N/A N=168 The STEPS - Totalis™ Trial

Phase 4 N=78 MiDAS I (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study

Phase 3 N=70 Safety Study to Lower the Risk of Heart Failure is Also Effective in Reducing Stiffness of the Arteries

N/A N=50 Pulmonary Artery Repair With Covered Stents

N/A N=275 FLUENCY® PLUS Endovascular Stent Graft for In-stent Restenosis