Phase 3 N=10 Determination of Sun Protection in Sunscreen Formulas (Study SR09-15)(P08236)(COMPLETED)
Sun Protection
Primary: Determination of Sunscreen Protection Factor (SPF) — 14.72; 15.00 Score on a scale
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N/A N=8 A Study to Measure the Sun Protection Factor (SPF) and Ultraviolet-A Protection Factor (UVAPF) of Four Developmental Sunscreen Formulations
Sunscreening Agents
Primary: Arithmetic Mean of Individual Sun Protection Factor (SPFi) Values — 33.1; 35.2; 35.2; 45.2 Ratio
N/A N=164 UV Exposure Assessed With Wearable Sensor and Sun Protection
Sunburn, Erythema · Sun Protection
Primary: Acceptability of Wearing UV Sensor and Receiving Text Messages — 22; 39.1; 40.1; 40.6 score on a scale — p=<0.01
N/A N=38 Sun Protection and Tanning Awareness in Rural Schools
Melanoma · Adolescents
Primary: Sun Protection Index Scores - Weekday — .179 score on a scale
N/A N=13 Clinical Study to Evaluate the Sun Protection Factor (SPF) of Three Sunscreen Products
Sunscreening Agents
Primary: Arithmetic Mean SPF Values — 29.2; 16.4; 28.2; 16.4 Ratio
Phase 1 N=30 Assessing a Natural Product Plus Bioadhesive Nanoparticle (BNP) Sunscreen
Skin Cancer
Primary: DNA Damage Level by Cyclobutane Pyrimidine Dimer (CPD) Measurement — 2.48; 2.18; 2.64; 1.14 Optical Density Units — p=0.003
Phase 2 N=16 Evaluation of the Protection Activity of Microfine Titanium Dioxide (Ti02), Pigmentary Ti02 and Bisoctrizole and Their Combinations in Voluntary Patients With Idiopathic Solar Urticaria (SU)
Idiopathic Solar Urticaria
Primary: Assessment of the Minimal Urticaria Dose (MUD) on Each Test Site, After Application of the Test Products — 4.33; 3.93; 3.80; 3.67 Photodermatosis Protection Factor
N/A N=26 Determination of the Sun Protection Factor (SPF) of a Cosmetic Daily De-fence Skin Cream
Sunscreening Agents
Primary: Arithmetic Mean of Individual Sun Protection Factor (SPFi) Value — 19.4; 14.0 Ratio (unit less)
N/A N=11 Clinical Study to Evaluate the Sun Protection Factor (SPF) of Sunscreen Products
Sunscreening Agents
Primary: Arithmetic Mean SPF Values — 13.9; 16.1; 14.3; 15.8 Ratio
N/A N=94 Measuring Real Time Decision-Making About Ultraviolet Radiation (UVR) Protection
Melanoma
Primary: Number of Participants Interviewed on UVR Protection Behaviors. — 25; 0; 0; 59 Participants
N/A N=15 Clinical Study to Evaluate the 80-Minute Water Resistant Sun Protection Factor (SPF) of Sunscreen Products
Sunscreening Agents
Primary: Arithmetic Mean SPF Values
N/A N=14 Sun Protection Factor (SPF) Determination of Two Sunscreen-Containing Lip Balms
Sunscreening Agents
Primary: Arithmetic Mean of Individual Sun Protection Factor (SPFi) Values — 17.3; 17.9; 19.3; 18.4 Ratio
Phase 1 N=72 Assessment of the Human Systemic Absorption of Sunscreen Ingredients
Systemic Exposure to Sunscreen Ingredients
Primary: Avobenzone Maximum Concentration — 1.8; 4.3; 4.0; 3.4 ng/mL
N/A N=41 Using Physical Tracking to Predict Sunburn
Prevention
Primary: Prevalence of Sun Protection Practices — 0.30; 0.43; 0.35; 0.41 proportion of practices/day
N/A N=368 Wearable Device Intervention to Improve Sun Behaviors in Melanoma Survivors
Melanoma (Skin)
Primary: Sun Protection Habits Index — 2.9; 3 scores on a scale
Phase 4 N=128 Cetaphil® Daily Facial Moisturizer With Sunscreen SPF 50+ - Human Repeat Insult Patch Test
Skin Irritation
Primary: Area of Erythema and Elevated Responses of Skin to Product — 91; 68; 33; 42 participants
N/A N=37 A Photoxicity and Photoallergy Study of a Developmental Face Cream, Serum and Lotion
Skin Care
Primary: Percentage of Participants With Photo-initiated Potential Sensitization Reaction — 0; 0; 0; 0 Participants
N/A N=543 Virtual Sun Safe Workplaces Ph II (SSW Works)
Skin Cancer · Occupational Exposure
Primary: Change From Baseline Employee Sun Protection Practices at 1 Year — 3.55; 3.30; 3.71; 3.46 score on a scale
N/A N=54 Skin Care Behaviors Among Melanoma Survivors and Their Families
Melanoma
Primary: Influence of a Patient's Melanoma Diagnosis on the Survivor's and Broader Family's Skin Cancer Prevention Activity. — 24; 22; 2; 5 Participants
N/A N=219 Strategies to Promote Skin Health
Skin Cancer · Skin Cancer Melanoma · Squamous Cell Carcinoma
Primary: Number of Indoor Tanning Sessions in the Last 30 Days — 1.98; 1.35; 1.92 Sessions in last month
N/A N=197 The Skin Savvy Study: A Behavioral Skin Cancer Prevention Intervention
Skin Cancer Prevention
Primary: Sun Stage of Change at 3 Months — 17; 5; 10; 12 Participants
Early Phase 1 N=70 Evaluation of Adherence to Topical Agents: Applying Communication Technology to Improve Sunscreen Use
Skin Cancer
Primary: Number of Days the Subjects Are Adherent to Using Sunscreen — 12.6; 23.6 days
N/A N=441 Interactive Tailored Website to Promote Sun Protection and Skin Self-Check Behaviors in Patients With Melanoma
Stage 0 Skin Melanoma · Stage I Skin Melanoma · Stage IA Skin Melanoma
Primary: Sun Protection Behavior Index — 3.54; 3.37 scores on a scale
N/A N=97 Validation of SHADE a Mobile Technology for Monitoring of Ultraviolet Exposure
Skin Cancer · Actinic Keratoses · Ultraviolet-Induced Change in Normal Skin
Primary: Quantification of Actinic Keratosis Using the UV Sensor vs. Control Group — 4.53; 4.74 lesions — p=0.8
Phase 2 N=100 Oral N-acetylcysteine for Protection of Human Nevi Against UV-induced Oxidative Stress/Damage in Vivo
Patients at Risk for Melanoma
Primary: UV-induced Oxidative Stress in Irradiated and Unirradiated Nevi — 94.6; 96.2; 33.6; 33.1 percentage of 8-OG expression in nevi — p=.65
N/A N=31 An Assessment of TLR4 and TOPK/PRPK Signaling in Sun Damaged Human Skin Acutely Exposed to Solar Simulated Light
Sun Damaged Skin
Primary: Number of TLR4 Signaling Pathway Analytes With a Significant Change in Expression From Baseline (Pre-solar Stimulated Light Exposure to 1 and 24 Hours Post Exposure)…
N/A N=38 Clinical Study to Evaluate the Efficacy of an Over-the-counter (OTC) Sunscreen Lip Balm Product
Sunscreening Agents
Primary: Mean Change From Baseline in Corneometer Measurements — 23.5; 24.2; 2.4; -0.6 Arbitrary units — p=<0.0001
N/A N=72 Study Using Spray Skin Protector Versus Conventional Treatment to Prevent Acute Radiodermatitis.
Radiodermatitis · Injury, Radiation
Primary: Number of Participants Categorized by RTOG Grading Scale — 12; 6; 11; 11 Participants
N/A N=38 Clinical Study to Evaluate the Efficacy of an Over-the-counter (OTC) Sunscreen Lip Balm
Sunscreening Agents
Primary: Mean Change From Baseline in Corneometry Value at Each Post-treatment Timepoint — 23.1; 23.3; 7.8; 0.1 Arbitrary units — p=<0.0001
N/A N=197 Radioprotective Light-weight Caps in the Interventional Cardiology Setting
Occupational Exposure to Radiation
Primary: Radiation Attenuation in Percentage (%) — 12; 91.5; 97.1 Percentage