Phase 2 N=52 Treatment of Post-Traumatic Brain Injury (TBI) Depression
Depression
Primary: Depression at Baseline — 27.5; 25.2 units on a scale
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Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=34 Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Depression & Other Neuropsychiatric Symptoms After Traumatic Brain Injury (TBI)
TBI Depression
Primary: Average Depression Score Using the Hamilton Depression (HAM-D) 17 Scale — 23.154; 23.076; 13.154; 12.706 units on a scale
N/A N=41 ACTIVE: Activity Therapy to Increase Veteran Engagement
Traumatic Brain Injury
Primary: Depressive Symptom Scores on CES-D — 30.06; 29.68 units on a scale
N/A N=105 Mindfulness-Based Cognitive Therapy Intervention to Treat Depression in Individuals With a Traumatic Brain Injury
Depression · Traumatic Brain Injury
Primary: Beck Depression Inventory - II — 25.47; 27.13; 18.84; 25.00 units on a scale
N/A N=55 Cognitive-Behavioral Therapy for Veterans With TBI
Insomnia · Traumatic Brain Injury
Primary: Change in Insomnia Severity — 8.833; 7.810; 9.625; 8.364 score on a scale
Phase 2 N=14 Lexapro for the Treatment of Traumatic Brain Injury (TBI) Depression & Other Psychiatric Conditions
TBI · Major Depression · Other Psychiatric Disorders
Primary: Montgomery-Asberg Depression Rating Scale (MADRS) at Baseline — 29.5; 33.6 units on a scale
N/A N=50 Valproate for Mood Swings and Alcohol Use Following Head Injury
Traumatic Brain Injury (TBI) · Alcoholism
Primary: Severity of Affective Lability Based on Shortened Agitated Behavior Scale — 9.22; 9.39 units on a scale
N/A N=1,516 Brain Injury Rehabilitation Improving the Transition Experience
Traumatic Brain Injury
Primary: Participation Assessment With Recombined Tools - Objective 17 (PART-O-17) — 1.30; 1.33 units on a scale — p=0.44
N/A N=133 Executive Dysfunction and Suicide in Psychiatric Outpatients and Inpatients
Traumatic Brain Injury · Suicidality
Primary: Iowa Gambling Test — -4.2; 1.7; 3.5; 5.3 Total Raw on a scale from -100 to 100 — p=>.05
N/A N=33 rTMS to Improve Cognitive Function in TBI
Traumatic Brain Injury
Primary: Trail Making Test Part B — 52.1; 45.3; 52.9; 50.8 T-score
N/A N=39 One-Day Life Skills Workshop for Veterans With TBI, Pain and Psychopathology
Mild Traumatic Brain Injury · Distress-based Psychopathology · Chronic Pain
Primary: World Health Organization-Quality of Life (WHO-QOL) — 6.11; 5.20 units on a scale
N/A N=30 Adjunctive Pregnenolone in Veterans With Mild TBI
Traumatic Brain Injury
Primary: Brief Assessment of Cognition in Affective Disorders (BAC-A) — 0.61; 0.80 units on a scale
N/A N=77 Improving Sleep in Veterans With TBI
Traumatic Brain Injury
Primary: Change in Self-reported Pain — 9.8; 10.2; 9.3; 10.0 Score on Pain Interference — p=<0.02
N/A N=91 Executive Functioning in TBI From Rehabilitation to Social Reintegration: COMPASS
Traumatic Brain Injury · Post-Traumatic Stress Disorder
Primary: Change From Baseline in Community Reintegration for Injured Service Members at 2 Months — 40.22; 37.79 score on a scale
N/A N=19 iTBS Study for Depression (Randomized)
Executive Dysfunction · Depression
Primary: Change in Montgomery-Asberg Depression Rating Scale (MADRS) Scores From Baseline to the End of the Intervention — 10.25; 13.33 score on a scale
N/A N=22 Treatment and Recovery Monitoring of Post TBI Symptoms
Brain Injuries, Traumatic
Primary: Change From Baseline in RPQ Score at Post-treatment Sessions — -4.6; -3.4 units on a scale
N/A N=50 Enhanced Problem-Solving Training
Brain Concussion
Primary: Brief Symptom Inventory-18 (BSI-18) Global Severity Index T-Score — 64.21; 65.26; 66.8; 61.35 units on a scale — p=.04
N/A N=6 Team Based Initiative Support
Traumatic Brain Injury
Primary: Number of Participants Who Reported 5 Themes — 6; 6; 6; 6 participants
N/A N=32 Effects of Bright Light Therapy in Mild Traumatic Brain Injury
Concussion, Mild · Post-Concussion Symptoms · Sleep Problems
Primary: Performance on Multiple Sleep Latency Test (MSLT) — 6.67; 7.32; 6.73; 7.88 minutes
N/A N=40 Transcranial Direct Current Stimulation for the Treatment of Deficits After Traumatic Brain Injury
Traumatic Brain Injury · Post Concussive Symptoms · Depression
Primary: Examiner Score — 0.617; 0.907; 0.865; 1.155 score on a scale
N/A N=23 Optimizing Cognitive, Environmental, and Neuromotor Stimulation in Traumatic Brain Injury
Traumatic Brain Injury · Dementia Alzheimers · Military Activity
Primary: Change in Executive Functioning as Assessed by the Trail Making Test — -9.2; 24.7 change in seconds — p=.323
N/A N=184 Intervention to Promote Survivor Resilience and Adjustment: Efficacy and Sustainability
Traumatic Brain Injury
Primary: Number of Subjects Completing the Two Structured Outpatient Intervention Programs Resilience and Adjustment Intervention (RAI) vs. RAI With Follow-up Booster Sessions…
N/A N=40 Relationship Between Attention and Emotional Regulation Post-Traumatic Brain Injury (TBI)
Traumatic Brain Injury
Primary: Baseline Measures Before Treatment
Phase 2 N=122 Brain Tissue Oxygen Monitoring in Traumatic Brain Injury (TBI)
Severe Traumatic Brain Injury
Primary: Fraction of Time That Brain Oxygen Levels Are Below the Critical Threshold of 20 mm Hg . — 0.15; 0.44 Proportion
N/A N=176 One-day Life Skills Workshop for Veterans With TBI, Pain, and Psychopathology: Evaluating Efficacy and Mechanism of Change
Traumatic Brain Injury · Chronic Pain · Post Traumatic Stress Disorder
Primary: The Depression Anxiety and Stress Scale (DASS-21) -TOTAL Score — 28.97; 30.77 units on a scale
Phase 1 N=52 Behavioral and Neuroimaging Changes After Cognitive Rehab in Traumatic Brain Injuries (TBI) and Mild Cognitive Impairment (MCI)
Mild Cognitive Impairment · Alzheimer's Disease · Traumatic Brain Injury
Primary: Memory Test Accuracy on Trained Stimuli — 53.9; 37.6; 48.9; 37.3 Percent correct
Phase 4 N=26 Methylphenidate for Attention Problems After Pediatric TBI
Traumatic Brain Injury · TBI · ADHD
Primary: Parent Outcome-Vanderbilt ADHD Parent Rating Scales (VADPRS) — 1.10; 1.47; .84; 1.14 units on a scale
Phase 4 N=15 Anterior Pituitary Hormone Replacement in Traumatic Brain Injury
Growth Hormone Deficiency · Traumatic Brain Injury
Primary: Maximum Oxygen Uptake at Baseline. — 29.0 mL/kg/min
N/A N=90 Anger Self-Management in Traumatic Brain Injury
Traumatic Brain Injury
Primary: Post-Treatment Response Rate From Baseline on Anger Measures - Participant Report — 46.7; 68.3; 21.7; 50.0 percentage of participants — p=0.047
N/A N=66 Transcranial Electrical Stimulation for mTBI
Mild Traumatic Brain Injury (mTBI) · Post-traumatic Stress Disorder
Primary: Change in Abnormal Magnetoencephalography (MEG) Slow-Waves (1-4 Hz) Activity — 1.8; 0.2; 0 units on a scale — p=0.01