N/A N=139 Automatic Control of Total Intravenous Anesthesia (ACTIVA)
Anesthesia
Primary: Depth of Hypnosis Adequacy — 79.4; 16.2 percentage of maintenance duration
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=140 Propofol Administered by Gastroenterologists by Target Controlled Infusion Pump During Endoscopy
Sedation · Endoscopy
Primary: Endoscopist's Satisfaction (Visual Analog Scale) About Sedation — 93; 83; 98; 87 units on a scale
N/A N=40 Effect-site Concentration of Propofol for I-gel Insertion During Anesthesia Induction With a Single-dose Dexmedetomidine
Igel
Primary: Concentration of Propofol — 5.46; 3.82 ug/ml
N/A N=60 Hemodynamic Responses During Induction: Comparison of Marsh and Schnider Pharmacokinetic Models
Healthy
Primary: SVI (Stroke Volume Index) Value Change From Baseline Level at the End of the First 25 Minutes. — -31.1; -31.7 ml/beat/m^2
N/A N=22 Medtronic Treat to Range (TTR) Closed-Loop Control
Diabetes Mellitus · Type 1 Diabetes · Metabolic and Nutritional Disorders
Primary: Safety and Feasibility of TTR Closed-loop Control System as Measure by the Count of Successful Hospital Admissions — 7; 4; 7; 2 Admissions
N/A N=40 Closed-Loop Fluid Administration System Using Hemodynamic Monitors
Intraoperative Volume Status · Postoperative Complications
Primary: Fluid Status During Surgery — 95 percentage of case time
N/A N=40 Closed Loop Propofol Administration in Pediatric Cardiac Surgery
Pediatric Cardiac Surgery · Intraoperative Awareness · Automated Drug Delivery
Primary: Percentage of Time Bispectral Index(BIS) Remains+/-10 of Target — 77.4; 75 percentage of time
N/A N=40 Probability Ramp Control of Propofol for EGD
Gastrointestinal Disease
Primary: Number of Participants Requiring Adjustment in Propofol Dosing — 16; 2 Participants
N/A N=40 Closed Loop Isoflurane Administration With Bispectral Index in Open Heart Surgery
Open Heart Surgery
Primary: Percentage of Time Bispectral Index Remains Within 10 of Target BIS of 50 — 75.9; 84.6 percentage of time
Phase 4 N=72 Total Intravenous Anesthesia in Sinus Surgery
Advanced Chronic Rhinosinusitis
Primary: Intraoperative Visual Field Assessment — 3.3; 4.3; 3.3; 4.2 units on a scale
N/A N=160 Trial Between a Computer-Guided Insulin Infusion Protocol Versus a Standard Insulin Infusion Algorithm in Medical ICU
Diabetes or With New Hyperglycemia
Primary: Mean Blood Glucose (BG) in mg/dl Among Glucommander Group Compared to Standard Insulin Infusion — 103.3; 117.3 mg/dl
Phase 4 N=24 Continuous TAP Blocks: Relative Effects of a Basal Infusion vs. Repeated Bolus Doses
Postoperative Pain
Primary: Sensory Deficit (Cold Roller), Mid-axillary Line — 9.2; 9.3 cm
N/A N=228 Multi-site Anesthesia Randomized Controlled STudy of End Tidal Control Compared to Conventional Anesthesia Results
Et Control Performance in Adult Population Surgery
Primary: Percent Duration Without Large Deviation of End-Tidal Anesthetic Agent (EtAA) Based on Extraction Algorithm (ALG) — 91.7; 80.8 percent duration — p=<.001
N/A N=206 FiO2 Closed Loop Control Ventilation
Wounds and Injuries · Respiratory Failure
Primary: Relative Duration With Oxygen Saturation (SpO2) Within Target Range [Time Frame: 12 Hours] — 0.53; 0.61 arbitrary units
N/A N=34 Awakening in Spine Surgery: A Comparison Between Clinical Signs and Bispectral Index
Spine Diseases
Primary: Extubation Time — 16.3; 16.6 min
N/A N=50 TetraGraph in Rocuronium Infusions
Surgery
Primary: Rocuronium Bolus Dose — 0.8 mg/kg
N/A N=70 Perineural Local Anesthetic Administration With a Continuous Infusion Versus Automatic Intermittent Boluses
Pain, Acute · Anesthesia, Local · Trauma Injury
Primary: Average Pain Queried on First Postoperative Day — 3; 0.0 score on a scale — p=0.033
Phase 3 N=2,684 Computerized Glucose Control in Critically Ill Patients
Hyperglycemia · Critical Illness
Primary: All-cause 90-day Mortality — 431; 447 participants
N/A N=180 GDT by Cardiac Index Trending Via a Radial Arterial Line in General Surgery
Reduction of Length of Hospitality Stay, Reduction of Perioperative Complications
Primary: Postoperative Complications — 52; 72 numbers of complications
Phase 4 N=42 Safety of Remifentanil Infusion
Urinary Tract Problem
Primary: Smooth cLMA Removal Condition (Score 1) — 86; 40 percentage of participants — p=<0.05
N/A N=30 Computer Assisted Instrument Guidance (CAIG) For Arterial Line Placement
Arterial and Midline Catheterization
Primary: Time Needed to Correctly Insert the Arterial or Midline Catheter. — 30.07; 44.76 Seconds
Phase 4 N=65 Sufentanil Infusion vs Sufentanil Bolus
Anesthesia
Primary: Time to Extubation — 230.5; 242.4 Minutes
Phase 4 N=17 Patient Controlled Intrathecal Analgesia With Bupivacaine for Chronic Low Back Pain
Pain, Intractable · Breakthrough Pain · Chronic Pain
Primary: Change From Baseline in the Numerical Rating Pain Scale (NRS) — 1.87; 1.81 units on a scale
N/A N=20 Safety and Efficacy of Initializing the Control-IQ Artificial Pancreas System Using Total Daily Insulin
Type 1 Diabetes Mellitus
Primary: Percent Time in Range at Home Pre/Post Intervention at Home — 77.8; 70.7; 68.9; 70.1 percentage of time spent in range — p=0.178
N/A N=68 Goal-Directed Intraoperative Fluid Management Using FloTrac© Monitoring in High-Risk Neurosurgical Patients
Intracranial Aneurysm · Brain Edema · Scoliosis
Primary: Number of ICU Stays Greater Than 1.5 Days — 13; 20 Number of ICU Stays greater that 1.5 Day
N/A N=120 Optimal VAsopressor titraTION Pilot Randomized Controlled Trial
Hypotension · Shock
Primary: MAP While on Vasopressors — 79; 70 mmHg
Phase 3 N=713 Heart And Lung Failure - Pediatric INsulin Titration Trial
Heart Failure · Respiratory Failure
Primary: ICU-Free Days — 20; 19.4 Days
N/A N=78 Continuous Infusion Versus Bolus Dosing for Pain Control After Pediatric Cardiothoracic Surgery
Congenital Heart Disease
Primary: Total Morphine Dosage — 0.9; 0.23 mg/kg
N/A N=60 Propofol EC50 for Inducing Loss of Consciousness in General Combined Epidural Anesthesia
Gastric Cancer
Primary: Propofol EC50 for Inducing Loss of Conciousness — 2.97; 3.36 ug/ml
Phase 4 N=50 A Low Dose Remifentanil Infusion During Tracheal Extubation in Surgical Intensive Care Unit Patients
Tracheal Extubation
Primary: Mean Arterial Pressure Changes During Extubation — 94; 97; 96; 97 mmHg