Clinical Trial Search

Primary: Mean Change of Total Tic Scores in K-YGTSS From Randomization (Baseline, Visit 2) to the Final Visit (Visit 7) — -9.62; -14.97 units on a scale

Primary: Stop Signal Reaction Time (SSRT) — 249; 245 milliseconds — p=0.49

Primary: Calculating Difference Between Means (Baseline and Endpoint Scores on the Yale Global Tic Severity Scale Subscales) — 15.82; 9.73; 12.36; 7.00 units on a scale — p=<.05

Primary: Yale Global Tic Severity Scale - Total Tic Score — -5.6; -3.4 Score on a scale — p=<0.05

Primary: Yale Global Tic Severity Scale (YGTSS) — 24.72; 23.56; 15.00; 12.94 units on a scale

Primary: Change in Global Severity of Tics and Clinical Condition as Measured by YGTSS — 20.19; 25.82 score on a scale

Primary: Yale Global Tic Severity Scale — 64.40; 26.40 units on a scale

Primary: Yale Global Tic Severity Score — 25.3 units on a scale

Primary: Improvement in Tic Severity — 24.3; 21.3 units on a scale

Primary: Hopkins Motor/Vocal Tic Scale (HM/VTS) — 1.22; 0.70 score on a scale

Primary: Change in Resting State fMRI Connectivity of SMA-mediated Brain Circuits — 0.0312; 0.261; 0.158 eta squared

Primary: Yale Global Tic Severity Scale — 23.2; 21.7 units on a scale (0 - 50)

Primary: Tic Severity — 59.3; 43.3; 37.67 score on a scale — p=0.1997

Primary: Mean Change From Baseline in Total Tic Score of the Yale Global Tic Severity Scale — -7.17; -7.16 score on a scale — p=0.996

Primary: Change From Baseline in the TTS of the YGTSS at Week 12 — -9.1; -8.4 units on a scale — p=0.692

Primary: Percentage of Participants With Adverse Events. — 76.4; 4.5; 3.6 Percentage of participants

Primary: Change From Baseline in Total Tic Score at Day 70 — -5.0; -14.29 units on a scale — p=0.0259

Primary: Change in Brain Activation - Insula Cortex — -0.071; -0.0094 Parameter estimate of BOLD Signal Change

Primary: Yale Global Tic Severity Scale (Y-GTSS) — 29.5; 31.5 units on a scale

Primary: Change From Baseline in the TTS of the YGTSS at Week 8 Between High-Dose TEV-50717-Treated Participants and Placebo-Treated Participants — -7.8; -7.0 units on a scale…

Primary: Change From Baseline to Week 6 in the Yale Global Tic Severity Scale (YGTSS) Total Tic Score (TTS) — -8.8; -7.3; -9.1 Score on scale — p=0.89

Primary: Mean Change From Baseline to Week 8 in Yale Global Tic Severity Scale (YGTSS) Total Tic Score — -8.2; -9.9; -14.5; -9.6 score on scale

Primary: Time From Randomization to Relapse in Participants Greater Than and Equal to (>=) 6 and Less Than (<) 18 Years During the Double-Blind R/WD — NA; 4.0 weeks

Primary: Change From Baseline to Week 8 in Yale Global Tic Severity Scale (YGTSS) Total Tic Score (TTS). — -13.35; -16.94; -7.09 Units on a scale — p=0.0020

Primary: Change From Baseline in Yale Global Tic Severity Scale (YGTSS) - Total Tic Score (TTS) — -12.34; -7.72 score on a scale — p==0.0028

Primary: Change in TTS — -14.29 units on a scale

Primary: The Change From Baseline to 6-week Scores for The Total Tic Subscale (TTS) — 6.2; 10.5; 10.2 units on a scale

Primary: Time Spent Using the Device Per Day of Use — 49.6 minutes per day

Primary: Yale Global Tic Severity Scale (YGTSS): — 45.2; 48.7; 48.8; 43.1 scores on a scale

Primary: Change From Baseline to Week 12 in the Yale Global Tic Severity Scale (YGTSS) Total Tic Score (TTS) — -6.8; -8.9 score on a scale — p=0.1768