Clinical Trial Search

Primary: Total Net D12FS Caries Increment (Total of Non-cavitated Lesions (D1), Cavitated Lesions (D2) and Sound Surfaces (S)) — 2.43; 2.68 weighted increment units/13 months…

Primary: Percentage of Participants With Tooth Loss Over 16 Year Period — 16.4; 13.8; 22.1; 16.9 percentage of participants

Primary: Change in Oral Plaque — -1.05; -0.03 log(percentage) — p=0.001

Primary: Bleeding on Probing (BOP) — 14.5; 12.3 percentage of sites

Primary: Sost Values for 6th Month — 1389.177; 1085.405; 1596.585; 2131.87 ng/ml — p=<0.01

Primary: Number of Participants Completing Study Protocol — 17; 34; 14; 30 Participants

Primary: Change From Baseline Gingivitis at Day 14 as Measured by Non-invasive Microimaging and Gingival Index. — 0.6; 0.15 units on a scale

Primary: Number of Bleeding Sites at Week 12 — 42.02; 67.36 number of bleeding sites — p=<0.0001

Primary: Number of Participants With Arrested Dental Caries, Assessed Using a Clinical Oral Examination — 48; 53 Participants

Primary: Microbial Levels — 11; 7; 15; 15 Participants — p=0.35

Primary: Dental Plaque Levels Measures on Scale of 0-2 — 0.391 units on a scale

Primary: Gingival Index (GI) — 1.04; 1.01 units on a scale — p=<0.05

Primary: Whole-mouth Mean Modified Gingival Index (MGI) Score at Day 42 — 1.880; 1.770 Unit on a scale

Primary: Proportion of Subjects With All Caries Arrested — 108; 101 Participants

Primary: Impact of Treatment on Change in Oral Health Measures — 0.186; 0.190 millimeters (probing depth difference) — p=0.957

Primary: Change in Periodontal Inflammation Surface Area (PISA) — 638.16; 288.72 square millimeters

Primary: Glycated Hemoglobin A1c — 8; 8.2 percentage of Glycated Hemoglobin A1c

Primary: Radiographic Bone Level — 2.69; 2.54 mm

Primary: Dental Plaque Index — 2.48; 2.42 Units on a scale — p=0.05

Primary: Metabolite Associated With Inflammation (Cadaverine) — 1.119186; 0.92077 ion count — p=<0.05

Primary: Overall PD Reduction — 1.25; 0.66 mm

Primary: HbA1c Levels in Blood — 11.42; 10.81 percentage of HbA1c levels in blood — p=0.05

Primary: Subjective Tooth Assessment: Number of Teeth With Normal and Abnormal Pulp — 111; 32 Teeth

Primary: Plaque Index — 1.07; 1.19; 1.31; 1.11 units on a scale — p=0.1561

Primary: Number of Lesions With Progression as Measured by Pairwise (PW) Comparison (N=Lesions) — 4; 14 Lesions — p==0.003

Primary: Rate of Preterm Birth — 878; 549 Participants — p=<0.05

Primary: Gingival Margin Plaque Index — 15.4; 12.81 Units on a scale — p=0.05

Primary: Fluoride Concentration in Dental Biofilm Fluid at Baseline — 0.24; 0.22 parts per million (ppm) of fluoride — p=0.8412

Primary: Number of New Tooth Root Caries Lesions — 1.1; 0.43; 0.56 new carious root surfaces

Primary: HbA1c Levels in Blood — 9.47; 10.27 Percentage — p=0.05