Phase 4 N=160 An Efficacy Study of Stain Control of a 67% Sodium Bicarbonate Containing Toothpaste on Chlorhexidine Tooth Staining
Oral Hygiene
Primary: Modified Lobene Stain Index (MLSI) at Week 6 — 0.97; 1.22 Score on a Scale — p=0.1313
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=279 Clinical Study to Investigate the Tooth Stain Removal Efficacy of Two Experimental Toothpastes Compared to a Standard Toothpaste When Used Twice Daily for 8 Weeks
Oral Hygiene
Primary: Change From Baseline in Mean Total Modified Lobene Stain Index (MLSI) Score at Week 8 — -2.33; -2.42; -0.38 score on a scale — p=<0.0001
N/A N=227 A Clinical Trial to Test the Effect of a Marketed Mouth Rinse on Stain Removal
Tooth Stain
Primary: Lobene Stain Index Composite Score at Day 15 — 2.568; 1.909; 1.575 units on a scale — p=<0.001
N/A N=220 Study to Investigate the Stain Control of Two Stannous Fluoride Dentifrices
Extrinsic Dental Stain · Oral Hygiene
Primary: Overall Modified Lobene Stain Index (MLSI) Mean Score at Week 4 — 1.38; 1.43; 1.42; 1.38 Score on a scale — p=0.2681
N/A N=129 Efficacy of Two Sonic Toothbrushes in Reducing Extrinsic Tooth Stain
Tooth Bleaching
Primary: Lobene Stain Index of Stain Intensity Scores 4 Weeks After Toothbrush Use — 0.89; 0.88; 1.13 score on a scale
N/A N=160 A Study Assessing the Effects of an Experimental Dentifrice in Maintaining Tooth Color Following Tooth Bleaching
Dentin Sensitivity · Oral Hygiene
Primary: Adjusted Mean VITA Shade Score at 24 Weeks After Tooth Bleaching — 12.00; 12.06 score on a scale — p=0.9141
Phase 2 N=123 A Study to Investigate the Stain and Plaque Removal Capability of Two Experimental Potassium Nitrate Dentifrices
Oral Hygiene
Primary: Change From Baseline in Overall Macpherson Modification of the Lobene Stain Index (MLSI) at 8 Weeks. — -0.32; -0.47; -0.38; -0.40 Score on a scale — p=0.6499
N/A N=86 Whitening Efficacy of Dentifrice Containing 10% High Cleaning Silica, 0.5% Sodium Phytate and 0.5% Sodium Pyrophosphate
Tooth Bleaching
Primary: Lobene Stain Index of Stain Extent Scores 4 Weeks After Dentifrice Use — 1.35; 1.64 score on a scale
N/A N=80 Resin Infiltration and Resin Infiltration With Bleaching in Improving the Esthetics for Fluorosis Stains
Caries Infiltration · Fluorosis · Dental Care
Primary: Esthetic Changes — 1.90; 5.50; 5.53; 5.35 score on a scale
N/A N=120 Clinical Evaluation of Enamel Microhardness Using Tooth Whitening Agents
Dental Atraumatic Restorative Treatment
Primary: Enamel Hardness — 348.4; 351.6; 354.5 Vickers hardness kg f/mm2 — p=0.231
N/A N=161 A Clinical Study Investigating the Effect of an Experimental Toothpaste Containing Stannous Fluoride in Improving Gingival Health
Dental Plaque · Gingivitis
Primary: Adjusted Mean Bleeding Index (BI) at Week 4 — 0.19; 0.21 score on a scale — p=0.2992
N/A N=253 Potential of Stannous Fluoride Toothpaste to Reduce Gum Disease
Gingivitis
Primary: Number of Bleeding Sites at Week 12 — 42.02; 67.36 number of bleeding sites — p=<0.0001
N/A N=96 Oral Tissue Tolerance of a Mouthrinse
Dental Health
Primary: Change in Tooth Color as Represented by ΔE at 8 Weeks Post Baseline From the CIElab Assessment — 0.909; 1.035 units on a scale — p=0.168
Phase 3 N=48 Reducing Bacteria That Cause Tooth Decay
Caries, Dental · Cariostatic Agents
Primary: Microbial Levels — 11; 7; 15; 15 Participants — p=0.35
Phase 3 N=23 Clinical Study to Evaluate Dental Plaque
Gingival Diseases
Primary: Dental Plaque Index — 2.48; 2.42 Units on a scale — p=0.05
N/A N=104 A Clinical Study to Examine the Effects of an Experimental Toothpaste Compared to a Regular Fluoride Toothpaste on Breath Odor in a Population With Gingivitis
Halitosis
Primary: Adjusted Mean Change From Baseline (Day 0, Pre-Brushing) to Week 3 (Pre-Brushing) in Breath Organoleptic Scores — -1.23; 0.07 Score on a scale — p=<0.0001
Phase 4 N=90 A Clinical Study Assessing the Effects of a Marketed Dentifrice on Tooth Sensitivity While Undergoing Tooth Bleaching
Dentin Sensitivity
Primary: Visual Analogue Scale (VAS) Scores of the Tooth Sensitivity Questionnaire Collected Through the Study — 33.8; 41.6; 36.9; 31.1 millimeter
N/A N=56 Ability of Four Toothpastes to Remove Plaque
Dental Plaque
Primary: Mean Change From Baseline (Pre-brushing to Post-brushing) in Turesky Score After Single Supervised Use (Test Product 1 Versus [vs] Test Product 4) After 4 Weeks — 2.90…
N/A N=61 Trial of Toothpaste to Reduce Plaque and Inflammation
Plaque · Inflammation
Primary: Change in Oral Plaque — -1.05; -0.03 log(percentage) — p=0.001
N/A N=38 Fluoride Varnish for Treatment of White Spot Lesions
White Spot Lesions
Primary: DIAGNOdent Readings at Baseline, Three and Six Months - Intergroup Comparison — 5.10; 6.01; 4.08; 5.50 units on a scale — p=0.636
Phase 4 N=130 A Clinical Study Investigating the Efficacy of a Stannous Fluoride Dentifrice in Improving Gingival Health After Twice Daily Use for 3 Weeks
Gingivitis
Primary: Whole Mouth Mean Bleeding Index (BI) at Week 3 — 0.14; 0.20 score on a scale — p=<0.0001
Phase 3 N=22 Study to Determine the Anti-plaque Efficacy of Commerical Toothpastes and an Oral Rinse
Dental Plaque
Primary: Plaque Index — 3.31; 3.31; 2.91 Units on a scale — p=0.05
N/A N=153 Study of an Experimental Toothbrush for Treatment and Prevention of Gingivitis
Dental Devices, Home Care
Primary: Whole-mouth Mean Modified Gingival Index (MGI) Score at Day 42 — 1.880; 1.770 Unit on a scale
Phase 4 N=108 Combined Bleaching Technique: Efficacy and Tooth Sensitivity
Tooth Bleaching · Tooth Sensitivity
Primary: Tooth Sensitivity (TS) — 1; 1; 1; 0 score on a scale
N/A N=196 A Study to Evaluate the Efficacy of a Stannous Fluoride Toothpaste With a Cetylpyridinium Chloride Mouthwash in Improving Gingival Health and Reducing Plaque Accumulation
Dental Plaque · Gingivitis
Primary: Overall Number of Bleeding Sites (NBS) at Week 12 (Toothpaste/Mouthwash Versus [vs.] Negative Control Toothpaste) — 10.1; 24.1 bleeding sites — p=<0.0001
Phase 3 N=29 Clinical Study to Compare Dental Plaque Control
Dental Plaque
Primary: Dental Plaque Index — 3.12; 2.90; 2.92; 2.94 Units on a scale — p=<0.05
N/A N=55 A Study to Evaluate the Effect of a Stannous Fluoride Toothpaste on the Oral Microbiome
Oral Health
Primary: Alpha Diversity at Baseline (Day 1) — 3.7; 3.5 Shannon index
Phase 3 N=98 A Phase 3 Clinical Study Investigating the Gingivitis Efficacy of a Test Dentifrice Containing Stannous Fluoride
Gingivitis
Primary: Evaluation and Comparison of Gingival Health Measured by Bleeding Index (BI) at 24 Weeks — 0.11; 0.19 Score on scale — p=<0.0001
Phase 3 N=626 The Efficacy of a Toothpaste to Reduce Sensitivity
Dentin Hypersensitivity
Primary: Hypersensitivity Tactile(Yeaple Probe) — 19.81; 13.94 units on a scale — p=0.05
N/A N=16 Prevention of Enamel Demineralization by Use of K18-smooth Surface Sealant
Dental Caries
Primary: Change in Mineral Density Determined by the Canary Caries Detection System — 23.424; 31.125; 35.563 Canary Number — p=0.0003