Phase 4 N=128 Partnership for Rapid Elimination of Trachoma
Trachoma
Primary: Community Prevalence of Trachoma and Ocular C. Trachomatis (CT) Infection at Baseline — 30.7; 30.3; 31.1; 30.5 community
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=3,345 Modified Instrumentation for Surgery to Correct Trichiasis
Trachoma
Primary: Number of Eyelids With Presence of Recurrent Trichiasis — 948; 1062; 721; 612 eyelids
Phase 4 N=1,452 Study of Azithromycin to Prevent Recurrent Trichiasis Following Surgery in Ethiopia
Trichiasis
Primary: Recurrent Trichiasis in Tetracycline and Azithromycin Groups — 45; 62 Participants — p=.047
Phase 4 N=1,347 Impact of Two Alternative Dosing Strategies for Trachoma Control in Niger
Trachoma · Chlamydia Trachomatis
Primary: Infection With Chlamydia Trachomatis Diagnosed by Use of NAATs [Nucleic Acid Amplification Test] — 57; 42; 5; 3 Participants
N/A N=42 The Effect of Oral Azithromycin in the Treatment of Chlamydial Conjunctivitis
Chlamydial Conjunctivitis
Primary: Total Number of Participants With Negative Chlamydia Direct Fluorescent Antibody (DFA) Test Results After Oral Azithromycin Treatments — 27 participants
N/A N=700 Repeat Surgery for Patients With Post-operative Trachomatous Trichiasis Trial
Trichiasis · Surgery
Primary: Number of Eyelids With Post-operative Trichiasis Within 12 Months — 94; 120 Eyelids — p=0.07
N/A N=52 A Surveillance and Azithromycin Treatment for Newcomers and Travelers Evaluation: The ASANTE Trial
Trachoma
Primary: The Proportion of Communities With C. Trachomatis Infection Prevalence of 1% or Below — 7; 4 community — p=>0.05
N/A N=4,914 Maximizing Trichiasis Surgery Success
Trichiasis · Surgery
Primary: Number of Eyes With Presence of Post-Operative Trichiasis Within 12 Months — 347; 504; 298 eyes — p=0.039
Phase 3 N=2,410 FLuorometholone as Adjunctive MEdical Therapy for TT Surgery (FLAME) Trial
Trachomatous Trichiasis (TT) · Eye Diseases · Eyelid Diseases
Primary: Incidence of Postoperative TT by One Year, as Determined by Trained Study Team Members — 218; 213; 32; 36 Study eyes — p=0.97
N/A N=27,473 Identification of TT Cases by Community Treatment Assistants: An Assessment
Trichiasis
Primary: TT Cases Screened Positive by CTA's and Confirmed by Graders — 9; 50 Participants
Phase 4 N=3,931 Azithromycin Reduction to Reach Elimination of Trachoma
Trachoma
Primary: Ocular Chlamydia Measured in a Population-based Sample of 0-9 Year-old Children — 0; 0 Participants
N/A N=150 Chalazion Conservative Treatment Trial
Chalazion Unspecified Eye, Unspecified Eyelid · Chalazion Left Eye, Unspecified Eyelid · Chalazion Right Eye, Unspecified Eyelid
Primary: Number of Participants With Complete Resolution — 13; 12; 11 participants
Phase 2 N=100 Oral Azithromycin Versus Doxycycline in Posterior Blepharitis
Posterior Blepharitis
Primary: Change of Blepharitis Symptoms Score — 1.8; 2.8 score — p=0.03
Phase 3 N=567 Treatment Failure of Chlamydial Infection in Males and Females in Youth Correctional Facilities
Chlamydial Infection
Primary: Assess Microbiological Failure of Recommended Azithromycin and Doxycycline Regimens in Uncomplicated Chlamydia Trachomatis Infection in a Setting Where Repeat Exposure…
N/A N=200 Genital CT Treatment to Pregnant Women to Prevent Adverse Pregnancy Outcomes: A Pilot RCT
Chlamydia Trachomatis Infection
Primary: Response Rate at Recruitment — 100; 100 Participants
Phase 1 N=65 Safety and Immunogenicity of a Chlamydia Vaccine CTH522
Trachoma
Primary: Solicited Local Injection Site Reactions — 2; 8; 3; 9 Participants — p=1
Phase 3 N=705 Phase III Clinical Trial of TRAVATAN Z in Ocular Surface Health
Open-angle Glaucoma · Ocular Hypertension
Primary: Mean Change at Day 90 From Baseline (Day 0) in Ocular Surface Disease Index (OSDI) Score — -9.1; -10.2 Units on a scale
N/A N=500 Antenatal Chlamydia Trachomatis and Neisseria Gonorrhoeae Testing to Prevent Adverse Neonatal Consequences
Chlamydia Trachomatis Infection · Neonatal Infection · Preterm Birth
Primary: Number of Women Diagnosed With C. Trachomatis and N. Gonorrhoeae Infection at Post-delivery — 2; 23 Participants
N/A N=399 Surveillance of Ocular Surface Flora (SURFACE)
Cataract
Primary: Percentage of Staphylococcus Epidermidis Species Susceptible and Resistant to Oxacillin on the Eyelid — 51; 48 Percentage of Species
Phase 1 N=17 Demodex Blepharitis Treatment Study
Chronic Blepharitis
Primary: Change in the Number of Demodex Mites — -3; -0.4 Mites
Phase 4 N=24 Study of the Progression of Bacterial Conjunctivitis Symptoms Upon Antibiotic Treatment
Bacterial Conjunctivitis
Primary: Exploratory Outcomes From Digital Photography — 17; 7 Participants
Phase 2 N=30 The Efficacy Of SCH1 In The Treatment Of Acute Infectious Conjunctivitis
Acute Infectious Conjunctivitis (Disorder)
Primary: Complete Clinical Resolution — 9; 0 Participants
Phase 4 N=77,664 Community Health Azithromycin Trial in Burkina Faso
Childhood Mortality
Primary: All-cause Mortality Rate in Children Aged 1-59 Months — 8.2; 10.0 deaths per 1000 person years
Phase 3 N=502 A Long-term Safety Study of Once-daily Travatan
Glaucoma, Open-angle · Ocular Hypertension
Primary: Mean Intraocular Pressure — 16.5 millimeters mercury (mm Hg)
Phase 4 N=30 Travoprost 0.004% Versus Pilocarpine 1% in Patients With Chronic Angle Closure Glaucoma (CACG)
Angle-closure Glaucoma
Primary: Mean Intraocular Pressure (IOP) — 15.77; 18.35 millimeters mercury (mm Hg)
Phase 4 N=162 Topical Treatment of Bacterial Conjunctivitis and Its Effect on Microbial Flora
Bacterial Conjunctivitis
Primary: Susceptability Changes in Streptococcus Pneumoniae Distal to the Site of Instillation — 0; 0; 0; 0 Percent of resistant isolates
Phase 4 N=31 Lipids of the Human Tear Film and Their Effect on Tear Stability
Blepharitis
Primary: Global Response to Therapy — 16; 41 eyes — p=.001
Phase 3 N=495 Treatment of Chlamydia Infection Comparing WC2031 Tablets With Vibramycin
Urogential Chlamydia Trachomatis Infection
Primary: Microbiological Cure Rate — 94.9; 94.6 percentage of participants cured
Phase 3 N=578 A Study of the Safety and Efficacy of Gatifloxacin in Patients With Bacterial Conjunctivitis
Bacterial Conjunctivitis
Primary: Percentage of Patients With Clearing (Clinical Success) of Conjunctival Hyperemia and Conjunctival Discharge at Day 6 — 74.9; 65.2 Percentage of Patients
N/A N=26 Probiotics for Chalaziosis Treatment in Children
Chalazion
Primary: Time Taken for a Complete Resolution of the Chalaziosis — 51.2; 28.4 days