N/A N=46 Prevention of Preterm Birth With a Pessary in Twin Gestations
Premature Birth · Short Cervix
Primary: Number of Participants With Preterm Delivery — 9; 8 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=321 17OHP for Reduction of Neonatal Morbidity Due to Preterm Birth (PTB) in Twin and Triplet Pregnancies
Preterm Birth
Primary: Newborn Respiratory Distress Syndrome (RDS) — 44; 18 Twins
N/A N=2,804 The Twin Birth Study: A Trial Comparing Planned Vaginal Birth to Elective Caesarean Section of Twins
Twin Pregnancy
Primary: Perinatal/Neonatal Mortality and/or Serious Neonatal Morbidity — 60; 52; 24; 17 Participants
Phase 3 N=1,311 A Trial of Pessary and Progesterone for Preterm Prevention in Twin Gestation With a Short Cervix
Short Cervical Length
Primary: Number of Participants With Delivery or Fetal Loss of Either Twin Prior to 35 Weeks Gestation — 84; 84; 86 Participants
Phase 4 N=66 Prophylactic Methylergonovine for Twin Cesarean
Twin; Complicating Pregnancy · Postpartum Hemorrhage
Primary: Change in Maternal Hemoglobin Level — 1.1; 2.1 g/dL
N/A N=5 Randomized Clinical Trial: Expectant Management vs Laser Treatment of Monochorionic Twins With Severe Selective Intrauterine Growth Retardation and Absent or Reverse Diastolic Flow in the Umbilical Artery
Intrauterine Growth Retardation
Primary: Survival — 100; 100 percentage of AGA babies who survived
N/A N=103 Twinrix Pregnancy Registry
Hepatitis
Primary: Number of Outcomes From Pregnancies With Reported Exposure Within 28 Days of Last Menstrual Period — 0; 0; 0; 0 Pregnancy Outcomes
Phase 4 N=108 Detemir Versus NPH for Type 2 Diabetes Mellitus in Pregnancy
Diabetes Mellitus, Type 2
Primary: Number of Neonates With Composite Adverse Neonatal Outcome — 31; 35 Participants
N/A N=1,509 Pregnancy and Neonatal Follow-up of Ongoing Pregnancies Established in Clinical Trial P05787 (P05712)
Pregnancy · Neonates
Primary: Number of Mothers in Current Follow Up Trial Experiencing Adverse Events (AEs) — 222; 214 Participants
N/A N=70 Using Mental Imagination to Prevent Excessive Gestational Weight Gain in Overweight and Obese Pregnant Women
Obesity · Weight Gain, Maternal
Primary: Percent Change in Body Weight — 10.9; 9.6 percentage change
N/A N=281 Maternal-Offspring Metabolics:Family Intervention Trial
Pregnancy · Weight Gain
Primary: Gestational Weight Gain (GWG) — 12; 10 kg — p=0.01
Phase 3 N=900 Assessment of Multiple Intrauterine Gestations From Ovarian Stimulation
Pregnancy · Unexplained Infertility
Primary: Multiple Gestation Rate Following Recruitment of Multiple Follicular Development With an AI, as Compared to CC and FSH. — 9; 8; 34 number of multiples
N/A N=16 AT GOAL: Adopting Technology for Glucose Optimization and Lifestyle in Pregnancy
Type2Diabetes · Pregnancy in Diabetic
Primary: Feasibility: Number of Participants Who Complete the Study Within 24 Month Time Period — 8; 8 Participants
N/A N=118 Weight Management for Improved Pregnancy Outcomes
Obesity · Pregnancy
Primary: Maternal Weight Change — 1.2; -2.6 kg
N/A N=48 Thyroid Hormone Dose Adjustment in Pregnancy
Pregnancy · Hypothyroidism
Primary: Proportion of Patients in Each Treatment Arm Euthyroid Through Gestation — 24; 21 participants
N/A N=312 Optimizing Health From Pregnancy Through One Year Postpartum
Obesity · Pregnancy Related
Primary: Maternal Weight — 196.59; 201.03; 193.70; 201.66 pounds — p=.80
N/A N=25 Metformin Versus Insulin in Pregnant Women With Type 2 Diabetes
Pregnancy Complications
Primary: The Number of Participants Who Achieved a Hemoglobin A1C <7% — 5; 12 Participants
Phase 4 N=81 Safety and Immunogenicity of Simultaneous Tdap and IIV in Pregnant Women
Pregnancy
Primary: Percentage of Participants With Injection-site Reactions Post Tdap and IIV4 Administration — 47.5; 48.6; 37.5; 45.9 percentage of participants
N/A N=360 Lifestyle and Pregnancy: The Clinical Effect of Lifestyle Intervention During Pregnancy in Obese Women
Maternal Obesity · Gestational Weight Gain · Obstetric Complications
Primary: Cesarean Section
N/A N=206 Determination of Abnormal Fetal Growth or Amniotic Fluid With Third Trimester Ultrasounds in Uncomplicated Pregnancies: A Randomized Trial
Uncomplicated Pregnancy · Abnormal Fetal Growth or Fluid
Primary: Number of Participants With Fetal Growth Restriction — 2; 8 Participants
N/A N=30 Maternal Fetal Device Performance Singleton
Pregnancy
Primary: Success Rate Calculated Based on Collection of Fetal Heart Rate Data From Investigational Devices on Subjects Enrolled in Each Gestational Age Group — 85.01; 92.27…
Phase 3 N=800 Improving Pregnancy Outcomes With Progesterone
Pre-term Birth · HIV-1-infection
Primary: Number of Participants Experiencing Preterm Births or Stillbirths — 36; 36 Participants
Phase 3 N=220 Effectiveness of Higher Aspirin Dosing for Prevention of Preeclampsia in High Risk Obese Gravida
Pre-Eclampsia · Hypertension in Pregnancy · Obesity
Primary: Number of Participants With Preeclampsia Diagnosis With Severe Features Based on Clinician Diagnosis — 37; 41 Participants
N/A N=122 Prevention of Preterm Birth With a Pessary in Singleton Gestations
Preterm Birth · Short Cervix
Primary: Number of Subjects Experiencing Preterm Birth — 26; 23 Participants
N/A N=921 Comparison of Two Screening Strategies for Gestational Diabetes (GDM2)
Gestational Diabetes · Pregnancy · Glucose Intolerance
Primary: Large for Gestational Age (LGA) Infant — 34; 35; 28; 34 Participants — p=0.668
N/A N=16 Acute Exercise Effects in Obese Pregnancy
Pregnancy Complications · Obesity · Pre-Eclampsia
Primary: Oral Glucose Insulin Sensitivity (OGIS) Index — 405.0; 426.0; 418.9 uU/mL
N/A N=95 Early Screening and Treatment of Women With Prediabetes in Pregnancy
Diabetes · Pregnancy
Primary: Number of Patients With a Diagnosis of Gestational Diabetes at 26 Weeks Gestation. — 19; 23 Participants — p=0.32
N/A N=128 Early Anatomy Scan for Evaluation of Obese Pregnant Women (EASE-O)
Obesity
Primary: Completion Rate for First Trimester Scans — 66 percent
Phase 3 N=750 Pregnancy in Polycystic Ovary Syndrome II
Pregnancy · Polycystic Ovary Syndrome
Primary: Live Birth — 72; 103 Participants — p=0.007
N/A N=54 Personalized Management of Body Weight During Pregnancy
Weight Gain During Pregnancy
Primary: Count of Women Who Have Excess Gestational Weight Gain — 10; 11; 11 Participants