N/A N=39 Impact of a Low-Carbohydrate Diet in Pediatric Type 1 Diabetes
Type 1 Diabetes
Primary: Change in HbA1c — 0.4; 0.3; -0.2 percentage
Clinical Trial Search
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N/A N=14 Low Carbohydrate Diet vs. High Carbohydrate Diet in Type 1 Diabetes
Type 1 Diabetes
Primary: Percentage of Time Spent in Euglycemia — 68.6; 65.3 Percentage of time
N/A N=6 Very Low Carbohydrate Diet as an Adjunctive Therapy for Youth Type 1 Diabetes
Type 1 Diabetes
Primary: Percentage of Time in Target Range of 70-180 mg/dL. — 49.64; 48.86; 60.78; 50.1 percent time spent 70 mg/dL - 180 mg/dL
N/A N=19 Metabolic Changes Induced by a Very Low Carbohydrate Diet in Youth With Type 1 Diabetes
Type1diabetes, Low Carbohydrate Diet
Primary: Percent Time in the Optimal Glucose Range — 71.20; 62.51 percentage of time — p=<0.001
N/A N=12 A Study to Determine Iatrogenic Hyperinsulinemia's Contribution to Insulin Resistance and Endothelial Dysfunction in Type 1 Diabetes
Diabetes Mellitus, Type 1
Primary: Change in Insulin Sensitivity Assessed as Glucose Infusion Rates — 8.6; 8.1 mg/kg FFM/min — p=<0.01
N/A N=29 Effect of High Carbohydrate vs. Low Carbohydrate Diet in Type 2 Diabetes
Diabetes Mellitus · Diabetes Mellitus, Type 2
Primary: Hepatic Glycogen Content and Rates of Gluconeogenesis in Subjects With Type 2 Diabetes — 8.2; 9.4; 17.4; 15.6 umol/kgFFM/min
N/A N=127 Low-carbohydrate Versus Low-fat Breakfast in Type 2 Diabetes
Dietary Habits
Primary: Change From Baseline Hemoglobin A1c at 12 Weeks — -0.3; -0.1 % of HbA1c
N/A N=150 Low-Carbohydrate Dietary Pattern on Glycemic Outcomes Trial
Diabetes · PreDiabetes · Metabolic Disease
Primary: Change in Hemoglobin A1c — -0.26; -0.04 percentage — p=<0.05
N/A N=15 Dietary Glycemic Index, Brain Function and Food Intake in Patients With Type 1 Diabetes Mellitus
Diabetes Mellitus, Type 1
Primary: Nucleus Accumbens Blood Flow — 1.13; 1.16; 1.15; 1.21 ml/g/min per ml/g/min
N/A N=58 Delish Study: Diabetes Education to Lower Insulin, Sugars, and Hunger
Diabetes Mellitus, Type 2
Primary: Frequency of Eating in Response to Cravings (Primary Mechanistic Outcome) — -20.39; -25.27 % of EMAs with craving related eating
N/A N=115 REmote SUpport for Low-Carbohydrate Treatment of Type 2 Diabetes
Type 2 Diabetes Mellitus in Obese
Primary: Change From Baseline in Participants' HbA1c — -2.3; -2.4 mmol/mol — p=0.8
N/A N=45 The Effect of Gluten-free Diet on New Onset Type 1 Diabetes (T1D)
Type 1 Diabetes
Primary: Change in C-peptide Area Under the Curve Measured by Mixed-meal Tolerance Test (MMTT) Between Group on GFD and Standard Gluten-containing Diet. — 1539; 1173 pmol*min/l…
N/A N=62 Effects of Low-calorie Sweetened Beverage Restriction in Youth With Type 1 Diabetes
Type 1 Diabetes
Primary: Glycemic Variability — 2.00; 3.91 percent
N/A N=64 Preferred Treatment of Type 1.5 Diabetes
Type 2 Diabetes Mellitus
Primary: Changes in Beta Cell Function Assessed by Fasting and Stimulated C-peptide Measured at 36 Months. — -0.4; -1.4; 0.1; 0.3 ng per ml
Phase 4 N=13 New Onset Type 1 Diabetes: Role of Exenatide
Type 1 Diabetes
Primary: The Role of Exenatide as Compared to Insulin Monotherapy in Reducing Postprandial Hyperglycemia.
N/A N=48 The LoBAG Diet and Type 2 Diabetes Mellitus
Type 2 Diabetes Mellitus
Primary: Change in Hemoglobin A1c From Baseline to Week 12 — 6.6; 7.2 percentage
N/A N=24 Digital Exercise for Middle-Aged Adults With Type 1 Diabetes and Other Absolute Insulin Deficiency Diabetes
Type 1 Diabetes · Latent Autoimmune Diabetes in Adults · Pancreatitis
Primary: Feasibility of Usage — 168 minutes/week
N/A N=24 Preservation of Pancreatic Beta Cell Function Through Insulin Pump Therapy
Diabetes Mellitus
Primary: Change in Mixed-meal-stimulated Peak C-peptide Value (Via Mixed-meal Tolerance Test) After 12 Months of Insulin Pump Therapy, Compared With MDI. — 1.8; 3.1 ng/mL
Early Phase 1 N=11 Pancreatic Enzyme Replacement and Glucose Regulation in Type 1 Diabetes
Type 1 Diabetes
Primary: Improvement in Glucose Regulation — 34.42; 34.42; 35.44; 39.03 ng*hr/mL — p=0.43
N/A N=15 Continuous Glucose Monitoring (CGM) With a Low Carbohydrate Diet to Reduce Weight in Patients With Pre-Diabetes
Pre-diabetes
Primary: Participant Satisfaction With Continuous Glucose Monitoring (CGM) — 10; 4; 1; 0 participants
N/A N=14 Isoenergetic High Intensity Interval Training and Moderate Intensity Training in Adults With Type I Diabetes
Diabetes Mellitus, Type 1
Primary: Mean Energy Expenditure Between HIIT and MICT — 264.5; 225.5 kcal — p=0.010
Phase 2 N=29 Naltrexone and Hypoglycemia in Type 1 Diabetes
Type 1 Diabetes · Hypoglycemia Unawareness
Primary: Cerebral Blood Flow — 1.7; 1.3 percentage of signal intensity change
N/A N=65 Return of First-phase Insulin Secretion in Type 2 Diabetes is Associated With Depletion of Pancreas Lipid
Type 2 Diabetes Mellitus
Primary: Changes in Liver Fat — 5.4; 7.3 percent liver fat — p=0.05
N/A N=30 Effect of Low Carbohydrate Versus Low Fat Diet in the Treatment of Dyslipidemia in Obese Children With Metabolic Syndrome
Metabolic Syndrome · Obesity · Dyslipidemias
Primary: Dyslipidemia Measures — 30; 32 mg/dL
N/A N=14 Exercise Snacks and Glutamine to Improve Glucose Control in Adolescents With Type 1 Diabetes
Diabetes Mellitus, Type 1 · Autoimmune Diseases · Diabetes Mellitus
Primary: HbA1c, Glycated Hemoglobin — 7.9; 8.3; 8.0; 8.4 percentage of total hemoglobin
Phase 4 N=24 A Study of Rapid-Acting Mealtime Insulin in Children and Adolescents With Newly Diagnosed Type 1 Diabetes Mellitus
Diabetes Mellitus · Type 1 Diabetes
Primary: Number of All Consented Participants — 12; 12 Participants
N/A N=13 Glutamine and Insulin Sensitivity in Type I Diabetes
Type I Diabetes Mellitus
Primary: Insulin Sensitivity — 0.1; 0.07 mL/kg/min per uU/mL
N/A N=12 Effect of Medium Chain Fatty Acids on Cognitive Function During Acute Hypoglycemia in Patients With Type 1 Diabetes
Diabetes Mellitus, Type 1
Primary: Immediate Verbal Memory — 15.85; 17.36; 14.97; 13.28 units on a scale
Phase 2 N=45 Diet Treatment Glucose Transporter Type 1 Deficiency (G1D)
GLUT1DS1 · Epilepsy · Glut1 Deficiency Syndrome 1, Autosomal Recessive
Primary: Neuropsychological Score of Sustained Attention — 11 Participants
Phase 3 N=560 Oral Insulin for Prevention of Diabetes in Relatives at Risk for Type 1 Diabetes Mellitus
Diabetes Mellitus, Type 1
Primary: Rate of Type 1 Diabetes Per Year Among Individuals in the Primary Stratum When Treated With Oral Inulin Versus Placebo — 0.088; 0.102 Proportion with diabetes/year