Mode
Text Size
Log in / Sign up

Parental autoimmune diseases associated with increased risk of asthma, eczema in offspringParental autoimmune diseases linked to higher allergy risk in children

AI-generated summary of the cited source, checked by automated accuracy review. How we work

Key Takeaway
Consider parental autoimmune history as a modest risk factor for childhood allergic diseases.

A systematic review and meta-analysis examined the relationship between parental autoimmune diseases (AIDs) and allergic diseases in offspring. The analysis included 12 studies of children born to parents with autoimmune diseases, though specific study settings and follow-up durations were not reported. No explicit comparator group was defined in the analysis.

For maternal AIDs, the meta-analysis found increased odds of asthma (OR 1.25, 95% CI: 1.09-1.43), eczema (OR 1.30, 95% CI: 1.13-1.50), and allergic rhinitis (OR 1.04, 95% CI: 1.02-1.07) in offspring. For paternal AIDs, increased odds were observed for asthma (OR 1.16, 95% CI: 1.06-1.27) and eczema (OR 1.13, 95% CI: 1.02-1.26). Absolute numbers for these outcomes were not reported.

Safety and tolerability data were not reported in the meta-analysis. Key limitations included potential bias in case ascertainment and inadequate adjustment for confounding factors. The authors note the mechanisms underlying these associations remain unclear.

For clinical practice, this evidence suggests parental autoimmune history may be a modest risk factor for allergic diseases in children, potentially aiding in early identification. However, the available evidence is limited, and larger high-quality studies are needed to confirm these findings. The associations observed should not be interpreted as causal relationships.

Researchers analyzed 12 previous studies to understand whether children born to parents with autoimmune diseases might be more likely to develop allergic conditions like asthma, eczema, and hay fever. They looked at data from children whose mothers or fathers had conditions where the immune system attacks the body's own tissues.

The analysis found that children of mothers with autoimmune diseases had about a 25% higher chance of developing asthma and a 30% higher chance of eczema compared to children whose mothers did not have these conditions. A smaller increased risk was also seen when fathers had autoimmune diseases. The study did not report any specific safety concerns, as it was looking at existing health records rather than testing a treatment.

It's important to be careful with these results for two main reasons. First, the studies included had potential biases and didn't fully account for other factors that could influence allergy risk. Second, this research only shows an association or link—it doesn't prove that a parent's autoimmune disease causes allergies in their child, nor does it explain how this connection might work.

Readers should understand that this is early evidence from a review of existing studies. If you or your child's other parent has an autoimmune condition, this doesn't mean your child will definitely develop allergies. It simply suggests there might be a slightly higher statistical chance, which doctors could consider as part of a child's overall health picture. More research is needed to confirm these findings.

What this means for you:
Early research links parents' autoimmune diseases to a slightly higher allergy risk in kids, but more study is needed.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedApr 2026
View Original Abstract ↓
Epidemiological studies have reported an increased risk of allergic diseases in children born to parents with autoimmune diseases (AIDs); however, the mechanisms underlying this association remain unclear. We conducted a systematic review and meta-analysis to explore the relationship between parental AIDs and allergic diseases in offspring. EMBASE, Web of Science, and PubMed databases were searched for articles published up to December 1, 2025. AIDs in both mothers and fathers were included. Allergic outcomes included asthma, eczema, and allergic rhinitis. A random-effects model was used to synthesize the data. Twelve studies were included in the final analysis, and the methodological quality ranged from moderate to high. Maternal AIDs (of any type) were associated with an increased risk of asthma (odds ratio (OR) 1.25, 95% confidence interval (CI): 1.09-1.43), eczema (OR 1.30, 95% CI: 1.13-1.50), and allergic rhinitis (OR 1.04, 95% CI: 1.02-1.07) in offspring. Paternal AIDs were also associated with a higher risk of asthma (OR 1.16, 95% CI: 1.06-1.27) and eczema (OR 1.13, 95% CI: 1.02-1.26) in offspring. This systematic review and meta-analysis demonstrate that parental AIDs are associated with an increased risk of asthma and eczema in children. However, the available evidence is limited by potential bias in case ascertainment and inadequate adjustment for confounding factors. Larger high-quality studies are needed to confirm these findings and to elucidate the underlying genetic and microbiome-related mechanisms. Such evidence may facilitate early identification and targeted prevention or management of allergic diseases in children of parents with AIDs.
Free Newsletter

Clinical research that matters. Delivered to your inbox.

Join thousands of clinicians and researchers. No spam, unsubscribe anytime.