Rare overlap of myasthenia gravis and Kennedy's disease identified in case reportRare Overlap Syndrome Linked to Myasthenia Gravis and Kennedy's Disease

This is a case report and literature review describing a single patient with acetylcholine receptor (AChR) antibody-positive myasthenia gravis (MG) and Kennedy's disease (KD), along with a review of previously reported cases. The patient was definitively diagnosed with overlap syndrome based on neurophysiological findings and androgen receptor gene testing. The literature review identified 4 additional cases of KD patients exhibiting myasthenic features, all of whom were AChR antibody-negative.

The authors aim to improve clinicians' recognition of this rare overlap syndrome and explore potential comorbid mechanisms. Limitations include the very small sample size (1 case report, 4 literature cases) and the retrospective nature of the review. No information on treatment, outcomes, or follow-up was reported.

Given the rarity of this overlap, the findings are primarily descriptive and hypothesis-generating. Clinicians should be aware that MG and KD can coexist, but the evidence is too limited to guide specific management changes.