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Myasthenia Gravis

Subtypes of Myasthenia Gravis

Generalized myasthenia gravis 6

15 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Myasthenia Gravis

13 trials tracked for Myasthenia Gravis: 2 in phase 3 or 4 and 1 with published results. The most-cited published study has 916 citations.

13Trials tracked
2Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 3 2 Phase 2 8 Other / NA 3
  1. Phase 3 Thymectomy Trial in Non-Thymomatous Myasthenia Gravis Patients Receiving Prednisone Therapy Completed · 916 cited
  2. Phase 3 A Phase 3 Open-Label Study of Eculizumab in Pediatric Participants With Refractory Generalized Myasthenia Gravis (gMG) Completed
  3. Phase 2 Efficacy and Safety of IGIV-C in Corticosteroid Dependent Patients With Generalized Myasthenia Gravis Completed
  4. Phase 2 Study to Test the Safety, Tolerability and Efficacy of UCB7665 in Subjects With Moderate to Severe Myasthenia Gravis Completed
  5. Phase 2 A Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of ARGX-113 in Patients With Myasthenia Gravis Who Have Generalized Muscle Weakness Completed
  6. Phase 2 Efficacy of Methotrexate in Myasthenia Gravis Completed
Show 7 more trials
  1. Phase 2 A Study of RVT-1401 in Myasthenia Gravis (MG) Patients Completed
  2. Phase 2 A Study of TAK-079 in People With Generalized Myasthenia Gravis Completed
  3. Phase 2 BeatMG: Phase II Trial of Rituximab In Myasthenia Gravis Completed
  4. Phase 2 Open Label Study of Subcutaneous Immunoglobulin (SCIg) in Myasthenia Gravis Completed
  5. N/A Clinical Trial Comparing Two Non-Surgical Treatments for Severe Blepharoptosis Completed
  6. N/A Acupuncture in Myasthenia Gravis (AcuMG) Completed
  7. N/A Clinical Trial to Improve the Magnetic Levator Prosthesis Completed

Showing the 13 most-cited and recently-updated of 13 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Myasthenia Gravis: what the trials found

Eculizumab demonstrated a significant reduction in the QMG Total Score at week 26 regardless of rescue treatment (p=0.0004). Additionally, 50% of patients receiving Eculizumab achieved a ≥3-point reduction in the MG-ADL total score without requiring rescue treatment.

Magnetic Levator Prosthesis (MLP) showed statistically significant improvements in interpalpebral fissure (IPF) during spontaneous blinks (p<0.001) and resting open positions (p=0.001). Furthermore, the proportion of non-closure during volitional blinks was significantly low following MLP intervention (p=0.001).

Prednisone use over a 3-year period showed varying time-weighted average QMG scores based on dosage; patients on lower average daily doses (32 mg) had lower mean QMG scores compared to those on higher average doses (54 mg).

Recent results — preliminary, needs further review

  • Acupuncture was evaluated in a Phase N/A study (N=24), but results are not yet corroborated.

For the clinician treating this condition

  • Eculizumab is associated with significant improvements in QMG scores and high rates of MG-ADL improvement without rescue medication.
  • Magnetic Levator Prosthesis (MLP) provides statistically significant improvements in eyelid opening measurements (IPF) during both spontaneous and resting states.
  • Prednisone dosage levels correlate with different mean QMG scores over a 3-year period.

AI synthesis of 0 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Questions about Myasthenia Gravis

Which specific antibodies must be present for Epysqli approval in myasthenia gravis?

Epysqli (eculizumab-sbja) is FDA-approved for generalized myasthenia gravis only in adult patients who test positive for anti-acetylcholine receptor (AChR) antibodies.

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Can thymoma be associated with myasthenia gravis and stiff person syndrome?

Yes, thymoma can be associated with both myasthenia gravis and stiff person syndrome, though this combination is very rare.

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Do complement inhibitors improve outcomes for myasthenia gravis patients?

Yes, complement inhibitors (eculizumab, ravulizumab, zilucoplan) significantly improve symptoms and daily functioning in AChR antibody-positive generalized myasthenia gravis, based on multiple trials and real-world studies.

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Is there a link between myasthenia gravis and the risk of autoimmune encephalitis?

Yes, people with myasthenia gravis have an increased risk of developing autoimmune encephalitis, likely due to shared autoimmune mechanisms and overlapping antibody targets.

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Can a ketogenic diet improve quality of life for myasthenia gravis adults?

Early research suggests a ketogenic diet may improve symptoms and quality of life in myasthenia gravis, but evidence is limited to one small pilot study.

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Does efgartigimod help improve symptoms for myasthenia gravis patients?

Yes, efgartigimod helps improve symptoms in myasthenia gravis patients, with most studies showing clinically meaningful improvements in daily living scores and muscle strength.

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See all 6 questions about Myasthenia Gravis →

All Myasthenia Gravis Articles