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Combined digital and paper audit feedback did not improve asthma prescribing versus digital-only in primary care.

Combined digital and paper audit feedback did not improve asthma prescribing versus digital-only in …
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Key Takeaway
Consider that combined digital and paper audit feedback showed no added benefit over digital-only for asthma prescribing in primary care.

This was a cluster randomized controlled trial conducted in 270 primary care practices in West Yorkshire. Practices were randomized to receive either combined digital and paper audit and feedback reports or digital-only reports on asthma prescribing. The intervention was delivered over seven bimonthly reports.

The primary outcome was the change in the proportion of preventer inhalers prescribed in pressurised metered-dose devices. The result showed no significant difference between the intervention groups. The risk ratio was 1.00 (95% CI 0.98 to 1.03). The absolute change was -0.15% in the intervention group and -0.19% in the control group.

Safety and tolerability were not reported in the abstract. Key limitations included practice mergers in the control group and background trends of mixed improvement following feedback. The certainty note states results are based on a cluster randomized controlled trial, with confidence intervals including no effect.

The practice relevance noted the demonstrated value of an efficient 'real-world' trial embedded within an existing quality improvement initiative. However, the do not overstate guidance clarifies there is no evidence that combined feedback was more effective than digital-only, and background improvements do not imply superiority.

Study Details

Study typeRct
EvidenceLevel 2
PublishedApr 2026
View Original Abstract ↓
BACKGROUND: Suboptimal use of preventer inhalers and salbutamol reliever overprescribing are associated with preventable asthma deaths and are a major source of primary care carbon emissions. Audit and feedback produces modest behaviour change by assessing clinical performance and delivering feedback to encourage improvement. Although feedback is increasingly delivered digitally, clinicians may respond more to additional printed feedback reports. We evaluated whether combined digital and paper feedback was more effective than digital-only feedback in promoting safer and greener asthma prescribing at the practice level. METHODS: In this parallel, cluster randomised controlled trial, all 273 primary care practices in West Yorkshire were assigned within their primary care network clusters by stratified, permuted block randomisation to receive seven bimonthly reports on asthma prescribing either in 'digital and paper' (intervention) or 'digital-only' (control) formats. The primary outcome was the proportion of preventer inhalers prescribed in pressurised metred-dose devices due to their high carbon footprint. Intervention group allocation was concealed. The intention-to-treat population was analysed and adjusted for both potential confounders and preintervention achievement. RESULTS: Final analysis assessed 270 practices in 26 clusters per arm due to practice mergers within the control group. There was no significant difference between the intervention groups based on change in the primary outcome (intervention-0.15%; control-0.19%; risk ratio-1.00; 95% CI 0.98 to 1.03) nor any secondary outcome. Analysis of both interventions combined showed a background trend of mixed improvement following feedback. CONCLUSIONS: There was no evidence that combined paper and digital feedback was more effective than digital-only feedback, despite the background of mixed improvements following both interventions. Challenges remain to understanding the barriers to influencing the prescribing of preventer inhalers and transitioning inhaler devices towards low-carbon 'green' alternatives; however, this study demonstrated the value of an efficient 'real-world' trial embedded within an existing quality improvement initiative. TRIAL REGISTRATION NUMBER: NCT05761873.
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