Scoping review details neurological involvement in relapsing polychondritis and VEXAS syndrome

This is a scoping review that examines neurological involvement in two conditions: relapsing polychondritis (RP) and VEXAS syndrome. The review's scope is to map the existing literature on these complications without conducting a new primary analysis.

The authors synthesize that in relapsing polychondritis, neurological involvement most frequently comprises meningitis, encephalitis, cranial nerve palsies, and stroke. For VEXAS syndrome, the neurological involvement is additionally characterized by peripheral nerve and muscle involvement. No pooled effect sizes or quantitative syntheses are provided, as this is a qualitative scoping review.

A key limitation noted by the authors is the current gap in knowledge regarding these complications. The review does not report a study population, sample size, intervention, comparator, follow-up period, or adverse events, as these details are not provided in the source.

The practice relevance of this synthesis is not specified. Clinicians should interpret these findings as a qualitative map of the literature, recognizing that the evidence base is incomplete and further research is needed to clarify the scope and management of these neurological complications.