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Home › Conditions › VEXAS syndrome

VEXAS syndrome

3 published articles · Updated continuously

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Clinical features and treatment responses in 40 male patients with VEXAS syndrome
Neurology Cohort
Clinical features and treatment responses in 40 male patients with VEXAS syndrome HMA treatment shows promise for VEXAS syndrome patients
This retrospective multicenter study of 40 male patients with VEXAS syndrome evaluated clinical features and various treatment responses.
New data on VEXAS syndrome suggests that hypomethylating agents may help improve clinical and biological responses in men.
Frontiers Apr 30, 2026
Scoping review details neurological involvement in relapsing polychondritis and VEXAS syndrome
Allergy & Immunology Sys. Review
Scoping review details neurological involvement in relapsing polychondritis and VEXAS syndrome Why Neurologists Must Watch These Two Conditions
This scoping review synthesizes evidence on neurological complications in relapsing polychondritis and VEXAS syndrome.
Imagine a patient with ear pain and red eyes.
Frontiers Apr 24, 2026
VEXAS Syndrome Clinical Features and Treatment Outcomes in a Chinese Cohort of 16 Patients
Allergy & Immunology Cohort
VEXAS Syndrome Clinical Features and Treatment Outcomes in a Chinese Cohort of 16 Patients Small study links UBA1 gene variants to blood and inflammatory issues in China
This retrospective cohort study of 16 Chinese patients describes main clinical features and treatment responses in VEXAS syndrome.
A specific genetic change called a UBA1 variant was found in 81 percent of patients in China with blood disorders and inflammation affecting…
Frontiers Apr 16, 2026

Questions about VEXAS syndrome

Did the study find differences in treatment responses between male and female VEXAS patients?

All available studies on VEXAS syndrome included only male patients, so researchers could not compare treatment responses between men and women.

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Are there specific clinical features that distinguish VEXAS syndrome in a Chinese patient group?

A Chinese study of 16 patients found that p.M41V is the dominant UBA1 mutation, and most showed typical symptoms like anemia, skin lesions, and ear inflammation, similar to global reports.

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What neurological complications are linked to VEXAS syndrome and relapsing polychondritis?

Neurological complications in VEXAS syndrome and relapsing polychondritis are uncommon but can include stroke, meningitis, cranial nerve palsies, and peripheral nerve or muscle issues.

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How did patients with VEXAS syndrome respond to various treatments in the study?

Patients with VEXAS syndrome often respond quickly to corticosteroids but struggle with long-term dependence. Hypomethylating agents like azacitidine show gradual, sustained benefits, particularly for blood counts, though inflammatory responses can take time to appear.

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