Systematic review finds vitamin D supplementation offers no lung function benefit for children with asthma

This systematic review and meta-analysis evaluated the impact of vitamin D supplementation on children diagnosed with asthma. The study pooled data from multiple trials to assess efficacy across various clinical outcomes. A total of 1239 participants were included in the analysis to determine if supplementation provided therapeutic advantages.

primary analysis focused on forced expiratory volume in one second, or FEV1. Statistical measures indicated no evidence of improvement in this key pulmonary function metric. Similar null results were observed for forced vital capacity and other respiratory indicators. The confidence intervals for these outcomes consistently crossed the line of no effect.

Secondary assessments included peak expiratory flow, fractional exhaled nitric oxide, and immunoglobulin E levels. None of these secondary outcomes demonstrated statistically significant changes attributable to the intervention. Clinical asthma control scores also failed to show meaningful enhancement. Safety data were not reported in the source studies included in this review.

The authors conclude that current evidence remains inconsistent regarding pulmonary benefits. Specifically, vitamin D does not appear to improve lung function in this population. Clinicians should not expect therapeutic gains from this specific intervention based on these findings.