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Laparoscopic-endoscopic cooperative surgery achieves R0 resection in gastric synovial sarcoma with no recurrence at nine monthsA minimally invasive surgery helped a woman recover from rare stomach cancer

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Key Takeaway
Consider laparoscopic-endoscopic cooperative surgery for gastric synovial sarcoma to avoid open surgery morbidity.

This case report details the experience of a 37-year-old woman in China who underwent laparoscopic-endoscopic cooperative surgery for gastric synovial sarcoma. The intervention aimed to achieve complete resection while minimizing surgical trauma compared to open procedures. Follow-up lasted nine postoperative months during which the patient remained asymptomatic. No local recurrence, regional lymph node involvement, or distant metastases were observed. Gastrointestinal symptoms were absent, and the patient maintained good performance status throughout the observation period. Safety data, including adverse events and tolerability, were not reported in this single-case series. The study does not provide comparative efficacy data against standard open surgery. The authors suggest this approach is a feasible and effective minimally invasive strategy for achieving R0 resection. Clinicians should interpret these findings cautiously given the limited sample size and lack of a control group. Further research is needed to validate these outcomes in larger cohorts.

Rare stomach cancer is a serious challenge for doctors. Most cases require a large open surgery to remove the tumor. This approach often leads to significant pain and a long recovery time. A report from China describes a different path for one patient. A 37-year-old woman faced this rare disease called gastric synovial sarcoma. Her medical team chose a minimally invasive technique called laparoscopic-endoscopic cooperative surgery. This method uses small incisions instead of one large cut. The goal was to remove the cancer completely while sparing the patient from the trauma of open surgery. The patient did not experience any local recurrence of the cancer. She also had no regional lymph node involvement or distant metastases. Her symptoms disappeared and she remained asymptomatic. Her performance status was good, meaning she felt well and could function normally. No adverse events were reported during her recovery. The follow-up period lasted nine postoperative months. This case suggests that this surgical approach is feasible and effective. It allows for complete removal of the tumor while avoiding the morbidity associated with open surgery. This report highlights a potential option for patients facing this difficult diagnosis.

What this means for you:
A minimally invasive surgery helped a woman recover from rare stomach cancer without the pain of open surgery.

Study Details

Study typeSystematic review
EvidenceLevel 1
PublishedJun 2026
View Original Abstract ↓
Synovial sarcoma is a malignant mesenchymal tumor, accounting for approximately 5–10% of all soft tissue sarcomas. To date, only 52 cases of primary gastric synovial sarcoma have been reported in the English-language literature. We report a rare case of primary gastric synovial sarcoma in a young woman. To the best of our knowledge, this is the second case in the past decade treated using combined laparoscopic and endoscopic surgery, and the first such case reported in China using this approach. A 37-year-old woman was admitted with a 9-month history of abdominal pain and a 3-month history of a gastric body tumor. Initial biopsy at an outside hospital suggested a spindle cell tumor. Immunohistochemistry and molecular testing confirmed gastric monophasic synovial sarcoma. The patient was transferred to our hospital for surgical treatment and underwent regular postoperative follow-up. After nine postoperative months, endoscopic examination revealed no local recurrence. No regional lymph node involvement or distant metastases were identified. The patient remained asymptomatic with good performance status and no gastrointestinal symptoms. Laparoscopic-endoscopic cooperative surgery is a feasible and effective minimally invasive approach for achieving complete (R0) resection of gastric synovial sarcoma while avoiding open surgery and its associated morbidity.
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