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Preemptive photobiomodulation therapy may reduce pain during dental and craniomaxillofacial anesthetic needle puncturesLight Therapy May Reduce Pain During Dental Needle Injections

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Key Takeaway
Consider preemptive photobiomodulation as a noninvasive adjunct for needle pain, but note the low certainty of evidence.

The authors conducted a meta-analysis to evaluate the impact of preemptive photobiomodulation therapy on pain levels during local anesthetic needle punctures. The study included patients undergoing dental and craniomaxillofacial procedures, comparing the intervention against placebo, sham, topical anesthetic, or no intervention. Several pain assessment scales showed significant reductions following the application of photobiomodulation, while one specific score showed no significant effect.

However, the authors noted several significant limitations regarding the data. These included substantial heterogeneity across the included studies and wide prediction intervals. Furthermore, the researchers identified methodological limitations and a risk of bias related to intervention deviations and outcome measurement. Consequently, the GRADE certainty of evidence for all outcomes was rated as very low.

From a clinical perspective, preemptive photobiomodulation may serve as a noninvasive adjunctive strategy to improve patient comfort and cooperation. This could be particularly beneficial for anxious patients or pediatric populations. Nevertheless, clinicians should interpret these findings with caution given the low certainty of evidence and the underlying methodological limitations identified in the analysis.

Researchers looked at data from 1,519 patients undergoing dental and facial procedures. They compared a light therapy called photobiomodulation to other methods, such as no treatment or a placebo, to see if it helped reduce pain when a needle is used to deliver local anesthesia.

The analysis found that patients who received the light therapy reported lower pain scores across several different measurement scales. However, the researchers noted that the evidence is not very strong. There was a lot of variation in how the studies were conducted, and the quality of the data was rated as very low by the experts.

Because the evidence is limited, it is not yet clear how much this treatment will help in a typical dental office. It may be a helpful extra step for patients who are anxious or for children, but more high-quality research is needed. You should talk to your dentist about whether this option is right for your specific needs.

What this means for you:
Light therapy may reduce needle pain, but the current evidence is limited and needs more study.

Common questions

Can light therapy help with dental needle pain?

The study suggests that preemptive photobiomodulation therapy may reduce pain scores during needle punctures. While the results show a reduction in several pain scales, the evidence is currently rated as very low certainty. This means while it shows promise, more research is needed to confirm its effectiveness.

Who is this treatment most helpful for?

This noninvasive light therapy may be particularly helpful for patients who are anxious or for children. It could improve comfort and cooperation during dental and craniomaxillofacial procedures. You should discuss your concerns about needle pain with your dental provider.

Is this treatment safe for dental patients?

The study did not report any specific adverse events or safety concerns regarding the light therapy. However, because the evidence is limited and the study quality was low, you should consult your healthcare provider to discuss the best way to manage your comfort during procedures.

Study Details

Study typeMeta analysis
Sample sizen = 1,519
EvidenceLevel 1
PublishedOct 2026
View Original Abstract ↓
OBJECTIVES: To evaluate the effectiveness of preemptive photobiomodulation therapy (PBMT) in reducing pain during local anesthetic needle puncture in dental and craniomaxillofacial procedures. DATA SOURCES: A systematic search of electronic databases was conducted through November 2025 in accordance with PRISMA 2020 guidelines. Review protocol was registered in PROSPERO (CRD42025641468). STUDY SELECTION/RESULTS: Randomized controlled clinical trials comparing PBMT with placebo, sham, topical anesthetic, or no intervention were included. Twenty-seven studies (n = 1519 participants) met the eligibility criteria, and 25 were included in the meta-analysis. Random-effects meta-analyses with Hartung-Knapp adjustment and subgroup analyses (topical anesthetic use) were performed. Mean differences (MD) with 95% confidence intervals (CI) and prediction intervals were calculated. Risk of bias and certainty of evidence were assessed using RoB 2 and GRADE. Heterogeneity was evaluated using I² and between-study standard deviation (τ). PBMT significantly reduced pain scores measured by VAS (MD-1.72; CI -2.87 to -0.57), PRS (MD -0.89; CI -1.59 to -0.20), and FLACC (MD -1.14; CI-1.90 to -0.37) whereas SEM showed no significant effect (MD -0.56; CI -1.72 to 0.60). Substantial heterogeneity was observed (I² = 96.7%-98.9%; τ = 0.93-1.97). Most studies presented low risk or some concerns, mainly related to deviations from intended interventions, outcome measurement, and selective reporting. GRADE certainty was rated as very low across all outcomes. CONCLUSIONS: PBMT may reduce pain during local anesthetic needle puncture. However, substantial heterogeneity, wide prediction intervals, and methodological limitations reduce confidence in the findings. Further standardized trials are needed to confirm efficacy and establish optimal parameters. CLINICAL SIGNIFICANCE: Preemptive PBMT may represent a promising noninvasive adjunctive strategy to reduce pain during anesthetic needle puncture, potentially improving patient comfort and cooperation, particularly in anxious and pediatric individuals. However, the current evidence remains limited by substantial heterogeneity, methodological variability, and very low certainty of evidence, highlighting the need for standardized irradiation protocols and well-designed clinical trials before routine clinical implementation can be recommended.
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