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High-volume PENG block with dexamethasone showed no analgesic advantage over conventional volume in primary total hip arthroplastyMore Numbing Fluid Does Not Mean Less Pain

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Key Takeaway
Consider that high-volume PENG block offers no analgesic benefit over conventional volume for primary THA.

This randomized, controlled trial evaluated 40 patients receiving primary total hip arthroplasty under spinal anesthesia, with 37 included in the final analysis. Participants were stratified into a high-volume group (18 patients) and a conventional-volume group (19 patients). The intervention involved a PENG block with 40 mL of 0.375% ropivacaine plus 5 mg dexamethasone for the high-volume group, compared to 20 mL of 0.375% ropivacaine with 5 mg dexamethasone for the conventional-volume group.

The primary outcome measured dynamic pain scores at 6 hours post-surgery. Results showed no significant difference between groups, with the high-volume group reporting a median pain score of 5 (IQR 4-6) versus a median of 4 (IQR 4-5) in the conventional-volume group. Secondary outcomes included lower limb sensory and motor block assessments at 3, 6, and 24 hours, as well as time to first walking and opioid consumption.

Safety data indicated that the high-volume PENG block did not increase the risk of quadriceps weakness. No adverse events, serious adverse events, or discontinuations were reported. Opioid-related complications and length of hospital stay were recorded as secondary outcomes, though specific comparative statistics for these were not detailed in the provided results. The study followed patients for 3, 6, and 24 hours for block assessments, with opioid consumption tracked up to 48 hours.

Limitations include the small sample size and the lack of reported p-values or confidence intervals for the primary outcome. Funding and conflicts of interest were not reported. The practice relevance concludes that high-volume PENG block is not superior to conventional-volume PENG block for improving post-operative analgesia in patients undergoing primary total hip arthroplasty.

The Hidden Pain of Hip Surgery

Getting a new hip joint is a big deal. It fixes a painful problem that stops people from walking or sleeping. But the surgery itself hurts. Doctors use special shots to numb the area so patients feel less pain while they wake up.

Many surgeons like to use a lot of numbing medicine. They think more medicine means better pain control. But using too much fluid can make the leg feel weak. Patients might not be able to walk right away. This makes recovery harder. We need to know if using extra medicine is really worth the risk.

In the past, doctors often guessed how much medicine to use. Some used a lot, some used a little. There was no clear answer on what worked best. This new study changes that thinking. It shows that adding more medicine does not make a difference.

Think of the nerves like a bundle of wires. They carry pain signals from the hip to the brain. When doctors inject medicine, it acts like a blanket. It covers the wires so pain signals cannot get through.

But here is the catch. If you pour too much blanket on the wires, the whole area gets heavy. The leg muscles get weak. This is called motor block. It is not good for walking. The goal is to cover the pain wires without making the leg heavy.

Forty patients got a new hip. They were split into two groups. One group got a standard shot with 20 milliliters of medicine. The other group got a large shot with 40 milliliters. Both shots included a small amount of dexamethasone, a steroid that helps reduce swelling. Doctors checked pain levels at three hours, six hours, and twenty-four hours after the surgery.

The main question was about pain at six hours. This is when patients are usually moving around. The group with the large shot did not feel less pain. Their pain scores were the same as the group with the standard shot.

There was no difference in how long it took to walk for the first time. There was also no difference in how much pain medicine patients needed later. The big shot did not stop pain better. It also did not make the leg weaker than the small shot.

But there is a catch. This study only looked at forty people. That is a small number. Small studies can sometimes miss important details. We need to see if this holds true for hundreds of patients.

Doctors who specialize in pain say this makes sense. The nerves are small. They do not need a huge amount of medicine to work. Adding extra fluid just pushes the medicine into the wrong places. It might hit the muscles instead of just the pain nerves. This causes weakness without adding benefit.

If you are planning hip surgery, talk to your doctor about the plan. You do not need to worry about getting too much medicine. Standard doses are safe and effective. You can expect to walk soon after surgery. Do not be afraid to ask questions about your pain plan.

This study has limits. It only included forty patients. All patients had the same type of hip surgery. The results might be different for other surgeries or older patients. We must wait for bigger studies to confirm these findings.

Doctors will likely keep using the standard amount of medicine. It is safe and works well. Future research will look at other ways to control pain. Maybe new medicines or different techniques will help. Until then, the current method remains the best choice. Patients can feel confident in their care plan.

Study Details

Study typeRct
EvidenceLevel 2
PublishedJan 2026
View Original Abstract ↓
BACKGROUND: Currently, the optimal volume of pericapsular nerve group (PENG) block for analgesia after total hip arthroplasty (THA) has not been clarified. In this trial, we investigated whether a high-volume PENG block has a superior analgesic effect than a conventional PENG block for primary THA. METHODS: Forty patients receiving primary THA under spinal anesthesia were enrolled and randomly divided into the high-volume PENG group (40 mL of 0.375% ropivacaine) and the conventional-volume PENG group (20 mL of 0.375% ropivacaine). Dexamethasone (5 mg) was added to the local anesthetic in both groups. A blinded researcher performed pain scores and lower limb sensory and motor block assessments at 3, 6, and 24 h after surgery. The time of first walking, time of first opioid consumption, total opioid consumption within 48 h, nerve block, opioid-related complications, and length of hospital stay were recorded. The primary outcome was the dynamic pain scores at 6 h post-surgery. RESULTS: Thirty-seven patients were included in the final analysis, among whom 18 were in the high-volume group and 19 in the conventional-volume group. There were no significant differences between the two groups in dynamic pain scores at 6h after surgery [median and interquartile range (p25, p75) 5(4,6) vs 4 (4,5)] and other secondary outcomes. CONCLUSIONS: The high-volume PENG block is not superior to conventional-volume PENG block in improving post-operative analgesia in patients undergoing primary THA and does not increase the risk of quadriceps weakness. TRIAL REGISTRATION: Chinese Clinical Trial Registry (ChiCTR, https://www.chictr.org.cn). Clinical trial registration number: ChiCTR2300077281.
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