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Home › Medications › ropivacaine

ropivacaine

11 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of ropivacaine

65 trials tracked of ropivacaine: 36 in phase 3 or 4 and 5 with published results. The most-cited published study has 65 citations.

65Trials tracked
36Phase 3 & 4
0Recruiting
5With published results
Phase distribution
Phase 4 28 Phase 3 8 Phase 2 7 Phase 1 1 Other / NA 21
  1. Phase 4 Ropivacaine Block Alone or With Perineural or Systemic Dexamethasone for Pain in Shoulder Surgery Completed · 65 cited
  2. Phase 3 Decadron as Adjuvant in Femoral Nerve Blocks in Knee Arthroscopy Completed · 16 cited
  3. Phase 4 Impact of Local Anesthetic Wound Infiltration on Postoperative Pain Following Cesarean Delivery Completed · 12 cited
  4. Phase 3 The Use of Intraperitoneal Ropivacaine in Bariatric Bypass Surgery Completed · 12 cited
  5. Phase 4 Comparative Study Between Levobupivacaine and Ropivacaine in the Hip Fractures of the Elderly Completed · 6 cited
  6. Phase 4 Liposomal Bupivacaine in Total Shoulder Arthroplasty Completed
Show 44 more trials
  1. Phase 4 Local Anesthesia Versus Saline Serum in Surgical Incision of Colorectal or Hepatic Surgery Completed
  2. Phase 4 Corticosteroid/Ropivacaine Versus Corticosteroid/Saline Injections for Knee Osteoarthritis Completed
  3. Phase 4 Efficacy of Peri-Incisional Multimodal Drug Injection Following Operative Management of Femur Fractures Completed
  4. Phase 4 Psoas Compartment Block Versus Periarticular Local Anesthetic for Total Hip Arthroplasty Completed
  5. Phase 4 Comparison of PIEB vs CEI for Labor Analgesia Completed
  6. Phase 4 A Clinical Trial of Two Periarticular Multimodal Drug Injections in Total Hip and Knee Arthroplasty Completed
  7. Phase 4 the Analgesic Duration of Dexmedetomidine Compared to Dexamethasone as Adjuncts to Single Shot Interscalene Block Completed
  8. Phase 4 Efficacy of Continuous Infusion Ropivacaine Interscalene Blocks Completed
  9. Phase 4 TAP Block Catheters vs Liposomal Bupivacaine for Pain Control After Colorectal Surgery Completed
  10. Phase 4 Anesthesia for Pain After Ankle Fracture Surgery Completed
  11. Phase 4 Sphenopalatine Ganglion Blocks RCT Completed
  12. Phase 4 Evaluation of Utility of Ultrasound Guided iPACK Block for Knee Extension After Total Knee Arthroplasty. Completed
  13. Phase 4 Efficacy of Multimodal Periarticular Injections in Operatively Treated Ankle Fractures Completed
  14. Phase 4 Liposomal Bupivacaine in Rotator Cuff Repair Completed
  15. Phase 4 Ropivacaine Plasma Concentrations and Pharmacokinetics Following Erector Spinae Plane Block in the Pediatric Population Completed
  16. Phase 4 Pre vs Post Block in Total Knee Arthroplasty (TKA) Completed
  17. Phase 4 Distribution, Pharmacokinetics and Extent of Sensory Blockade in ESP Blocks Completed
  18. Phase 4 PEMF and PEC Blocks in Mastectomy Reconstruction Patients Completed
  19. Phase 4 Septorhinoplasty Post-operative Pain Control With SPG Nerve Block Completed
  20. Phase 4 Effects of Epidural Local Anesthetics on Propofol Induction Completed
  21. Phase 4 Spinal Anaesthesia With Levobupivacaine 0.5% and Ropivacaine 0.75% for Lower Limb Orthopaedic Surgery Completed
  22. Phase 4 Efficacy of Multimodal Peri- and Intraarticular Drug Injections in Total Knee Arthroplasty Completed
  23. Phase 4 The Use of Bupivacaine and Ropivacaine for Sciatic Nerve Block Completed
  24. Phase 4 Periarticular Multimodal Drug Injections in Total Knee Arthroplasty Completed
  25. Phase 3 Ultrasound Guided Supraclavicular Nerve Block Completed
  26. Phase 3 Ropivacaine Versus Bupivacaine as Preemptive Analgesia in Surgical Site in Ankle Fracture Patients Completed
  27. Phase 3 Bilateral Continuous Erector Spinae Blocks for Post-Sternotomy Pain Management: A Pilot Study Completed
  28. Phase 3 Evaluate Use of Caudal Nerve Blocks in Adult Penile Prosthesis Completed
  29. Phase 3 Exparel Use in Adductor Canal Block After Total Knee Arthroplasty Completed
  30. Phase 3 Evaluate the Use of Paravertebral Block in Reconstructive Breast Surgery Completed
  31. Phase 2 Regional TAP Block for Bariatric Patients Completed
  32. Phase 2 Total Knee Arthroplasty Infiltration Study for Postoperative Analgesia Completed
  33. Phase 2 The Prevention of Hypotension After Epidural Analgesia After Major Surgery Completed
  34. Phase 2 Analgesic Efficacy of Inter Pleural Ropivacaine Road in Post Thoracotomy Pain for Oncologic Surgery Completed
  35. Phase 2 Effectiveness of Clonidine, Dexmedetomidine, and Fentanyl Adjuncts for Labor Epidural Analgesia Completed
  36. Phase 2 Periarticular Injection Versus Peripheral Nerve Block in Total Hip Arthroplasty Completed
  37. Phase 2 Erector Spinae Plane Block for Uncomplicated Renal Colic Completed
  38. Phase 1 The Study of Regional Hemodynamic Changes After Specific Brachial Plexus Block by Ultrasound Guidance Completed
  39. N/A Interscalene Brachial Plexus Block Combined With Suprascapular Nerve Block Completed
  40. N/A Study of Intramuscular Ropivacaine Injections for Treatment of Pediatric Headache Completed
  41. N/A Supraclavicular Brachial Plexus Block Using Ropivacaine Alone and With Dexmedetomidine Completed
  42. N/A Effectiveness and Acceptability of Stellate Ganglion Block for Posttraumatic Stress Disorder Symptoms - Effectiveness Completed
  43. N/A Decision Support for Intraoperative Low Blood Pressure Completed
  44. N/A Efficacy of Multimodal Perioperative Analgesia With Periarticular Drug Injection in Total Knee Arthroplasty(TKA) Completed

Showing the 50 most-cited and recently-updated of 65 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Comparing Eight Nerve Block Combinations and Local Infiltration Analgesia for Total Knee Arthroplasty
Anesthesiology & Pain Medicine RCT
Comparing Eight Nerve Block Combinations and Local Infiltration Analgesia for Total Knee Arthroplasty Nerve Block Combination May Shorten Hospital Stays After Knee Surgery
A randomized trial evaluates whether an eight-nerve block technique reduces opioid consumption and hospital stay compared to standard LIA.
A new nerve block technique for knee replacement patients showed lower opioid use and shorter hospital stays compared to standard local inje…
Sep 11, 2026
Lidocaine-esketamine infusion reduces movement-evoked pain and opioid consumption in hepatic resection patients
Anesthesiology & Pain Medicine RCT
Lidocaine-esketamine infusion reduces movement-evoked pain and opioid consumption in hepatic resection patients New drug combination reduces pain after liver surgery
This randomized controlled trial of 304 patients undergoing elective hepatic resections found that a lidocaine-esketamine infusion significa…
A new mix of lidocaine and esketamine may lower pain and opioid use for patients recovering from liver surgery during the first three days.
Sep 7, 2026
Programmed intermittent boluses of ropivacaine do not reduce opioid consumption compared to continuous infusion
Anesthesiology & Pain Medicine RCT
Programmed intermittent boluses of ropivacaine do not reduce opioid consumption compared to continuous infusion Trial Shows Different Delivery Methods for Heart Surgery Pain Relief
This randomized trial of 240 adults undergoing open heart surgery found no significant difference in postoperative opioid consumption betwee…
A study of heart surgery patients found that two different ways of delivering local numbing medicine resulted in similar pain relief.
Sep 6, 2026
Obese parturients require 1.597 times higher norepinephrine dose to prevent hypotension during cesarean delivery
Diabetes & Endocrinology RCT
Obese parturients require 1.597 times higher norepinephrine dose to prevent hypotension during cesarean delivery Trial shows obese patients need more medication for stable blood pressure
This randomized, double-blind, dose-response study of 200 parturients found that obese patients required significantly higher norepinephrine…
New research shows that women with a higher BMI need specific, higher doses of norepinephrine to maintain steady blood pressure during C-sec…
Aug 10, 2026
Perineural dexmedetomidine combined with ropivacaine reduces pain and hospital stay after VATS
Anesthesiology & Pain Medicine Meta-analysis
Perineural dexmedetomidine combined with ropivacaine reduces pain and hospital stay after VATS Adding Dexmedetomidine to Nerve Blocks Eases Pain After Lung Surgery
This meta-analysis of randomized controlled trials evaluates the efficacy of perineural dexmedetomidine combined with ropivacaine for patien…
Adding dexmedetomidine to standard nerve blocks cuts pain and shortens hospital stays after lung surgery, without extra side effects.
Aug 4, 2026
Adding dexmedetomidine to dexamethasone does not prolong analgesia in upper limb surgery
Anesthesiology & Pain Medicine RCT
Adding dexmedetomidine to dexamethasone does not prolong analgesia in upper limb surgery Combining two drugs offered no pain relief advantage over one drug alone
This randomized, triple-blind trial in 100 patients undergoing upper limb surgery found that adding i.v.
A trial of 100 patients found that adding dexmedetomidine to dexamethasone did not extend pain relief or reduce opioid use after upper limb …
May 1, 2026
taVNS with ropivacaine block reduces chronic postsurgical pain after off-pump CABG in elderly patients
Anesthesiology & Pain Medicine RCT
taVNS with ropivacaine block reduces chronic postsurgical pain after off-pump CABG in elderly patients Ear Stimulation Might Cut Long-Term Heart Surgery Pain
This randomized controlled trial in 260 elderly patients undergoing off-pump coronary artery bypass grafting found that transcutaneous auric…
A simple ear device may help older patients avoid long-term pain after heart surgery.
Apr 22, 2026
High-volume PENG block with dexamethasone showed no analgesic advantage over conventional volume in primary total hip arthroplasty
Anesthesiology & Pain Medicine RCT
High-volume PENG block with dexamethasone showed no analgesic advantage over conventional volume in primary total hip arthroplasty More Numbing Fluid Does Not Mean Less Pain
This randomized, controlled trial enrolled 40 patients undergoing primary total hip arthroplasty under spinal anesthesia.
Giving doctors more numbing medicine around the hip nerve does not help patients feel less pain after surgery.
Apr 18, 2026
Preoperative femoral nerve block reduces rebound pain after knee arthroplasty versus postoperative block
Rheumatology RCT
Preoperative femoral nerve block reduces rebound pain after knee arthroplasty versus postoperative block Give Nerve Block Before Surgery To Stop Pain
In an RCT of 186 patients undergoing total knee arthroplasty, preoperative femoral nerve block with ropivacaine reduced rebound pain inciden…
Getting a pain-numbing shot before knee surgery cuts rebound pain in half, helps patients sleep better, and reduces the need for strong pain…
Frontiers Apr 10, 2026
Network meta-analysis compares 155 analgesic regimens for pain after knee and hip arthroplasty
Anesthesiology & Pain Medicine Meta-analysis
Network meta-analysis compares 155 analgesic regimens for pain after knee and hip arthroplasty Study Compares 155 Pain Relief Methods After Knee and Hip Replacement Surgery
A network meta-analysis of 211 RCTs involving 22,972 patients compared 155 analgesic regimens for postoperative pain after knee or hip arthr…
Patients recovering from knee or hip surgery can find which of 155 pain relief methods best controls pain and improves movement in the first…
Apr 9, 2026
Pilot RCT finds non-significant pain reduction with ESPB ropivacaine versus saline for ureteral stones
Anesthesiology & Pain Medicine RCT
Pilot RCT finds non-significant pain reduction with ESPB ropivacaine versus saline for ureteral stones Small pilot study tests nerve block for kidney stone pain in emergency department
A pilot randomized clinical trial of 24 ED patients with ureteral stones compared erector spinae plane block (ESPB) with ropivacaine 0.5% ve…
A small pilot study tested a nerve block injection for severe kidney stone pain in 24 emergency department patients.
Apr 7, 2026