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Withdrawal from overused medication and prophylactic treatment are key pillars for managing medication-overuse headacheWithdrawal and Prevention Help Manage Medication Overuse Headaches

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Key Takeaway
Recognize that medication-overuse headache is preventable and requires withdrawal from overused medications as a primary treatment.

This narrative review explores the pathophysiology and clinical management of medication-overuse headache (MOH). The authors define MOH based on ICHD-3 criteria, which include a pre-existing headache disorder, at least 15 headache days per month, and medication overuse for at least 3 months.

The review synthesizes the underlying mechanisms of the condition, identifying central and peripheral sensitization of the trigeminovascular system, impaired descending pain modulation, and cortical hyperexcitability as key drivers. The authors argue that while the condition is entirely preventable, it currently lacks sufficient clinical awareness among providers.

Treatment strategies focus on withdrawal from overused medications and the initiation of prophylactic treatment. The authors note that withdrawal is a fundamental pillar of management. Limitations regarding specific clinical outcomes or trial data were not reported in this review. The findings suggest that improving clinician awareness of MOH diagnosis and the necessity of withdrawal protocols is essential for improving patient outcomes.

How this fits prior evidence

This narrative review addresses a gap in clinical awareness regarding the prevention and management of medication-overuse headache. It builds upon prior evidence regarding the management of chronic migraine with medication overuse, which previously highlighted the use of eptinezumab with education to reduce migraine days.

Medication overuse headache (MOH) occurs when a person takes acute headache medication too frequently. To be diagnosed with this condition, a person must have a pre-existing headache disorder and have used medication for at least 3 months, resulting in 15 or more headache days per month.

Research suggests that these headaches are linked to changes in the body. These include the sensitization of the trigeminovascular system, problems with how the body blocks pain, and increased activity in the brain's cortex. These factors can make the pain harder to manage over time.

While these headaches are entirely preventable, they are not always recognized in clinical settings. Treatment focuses on two main pillars: withdrawing from the overused medication and starting a preventative treatment. Because this information comes from a narrative review, it provides a general overview of the condition rather than results from a specific clinical trial.

What this means for you:
Medication overuse headaches are preventable and are managed through medication withdrawal and preventative care.

Common questions

What is a medication overuse headache?

A medication overuse headache occurs when a person uses acute headache medication for at least 3 months. To meet the official diagnosis, the person must have a pre-existing headache disorder and experience at least 15 headache days per month due to the overused medication.

How is medication overuse headache treated?

Treatment for these headaches relies on two main pillars. The first is the withdrawal from the overused medication. The second is the use of prophylactic, or preventative, treatment to manage the condition and address the underlying sensitivity of the nervous system.

Why does overusing medication cause more headaches?

Overusing medication can lead to changes in the body's pain system. This includes the sensitization of the trigeminovascular system, impaired descending pain modulation, and cortical hyperexcitability. These factors can make the brain more sensitive to pain signals over time.

Study Details

Study typeSystematic review
EvidenceLevel 1
PublishedOct 2026
View Original Abstract ↓
Medication-overuse headache (MOH) is a secondary headache disorder caused by the regular overuse of acute headache medication. According to the International Classification of Headache Disorders (ICHD-3), MOH is diagnosed in individuals with a pre-existing headache disorder when headache days reach 15 or more days per month and medication overuse persists for 3 or more months. MOH is entirely preventable but lacks clinical awareness. A pillar in the treatment of MOH is withdrawing from the overused medication. Sometimes withdrawal is combined with prophylactic treatment. The pathophysiological mechanisms are not fully elucidated. The following mechanisms are suspected to be involved: central and peripheral sensitization of the trigeminovascular system, impaired descending pain modulation, and cortical hyperexcitability. This narrative review provides a current overview of the epidemiology, diagnosis, pathophysiology and treatment of MOH.
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