Are there new genetic markers for Alzheimer disease found in veteran populations?
Researchers have been searching for genetic markers that increase the risk of Alzheimer's disease. A recent large-scale study included data from the VA Million Veterans Program (MVP), which includes veterans of European, African, and Hispanic ancestry. This study found several new genetic locations (loci) linked to Alzheimer's in these veteran populations, adding to the known risk factors beyond the well-known APOE gene.
What the research says
A meta-analysis that included the VA Million Veterans Program (MVP) for the first time identified new genetic markers for Alzheimer's disease and related dementias in veteran populations 5. The study conducted genome-wide association studies (GWAS) in European, African, and Hispanic ancestry groups from the MVP. Apart from the APOE region, the analysis found 17 new genetic loci in European ancestry veterans, 4 new loci in African ancestry veterans, and 3 new loci in Hispanic ancestry veterans 5. These findings expand the known genetic architecture of Alzheimer's disease by including diverse veteran populations that have not been well-studied before. The study also used brain gene expression data to explore the function of these new genetic variants 5. Other large genetic studies have also identified new risk loci for Alzheimer's and related dementias, such as a 2022 study that found 42 new loci 9 and a 2024 study that found novel loci for all-cause dementia 10. However, the MVP study is unique in its focus on veteran populations and inclusion of multiple ancestries.
What to ask your doctor
- What do these new genetic markers mean for my personal risk of Alzheimer's disease?
- Should I consider genetic testing based on these findings, and what are the pros and cons?
- How do these veteran-specific genetic findings compare to known Alzheimer's risk factors like the APOE gene?
- Are there any ongoing studies or clinical trials for veterans that use these new genetic markers?
- Can lifestyle changes or treatments reduce risk if I have one of these genetic markers?
This question is drawn from common patient questions about Genetics & Precision Medicine and answered using cited medical research. We do not provide individualized advice.