Dementia

All Dementia Articles

• Rapid advancements in imaging and blood-based biomarkers are transforming the diagnosis and management of ADRD
• Periodontal disease is associated with a 2.67 odds ratio for Alzheimer's disease
• Extended occupational therapy showed no significant improvement in behavioral symptoms for dementia patients
• MIND diet shows greater cognitive improvement in community-dwelling adults with high biomarker levels over three years
• Regulatory suspension prohibits DCLVA use for Alzheimer's disease due to unresolved physiological uncertainties and scientific gaps
• Ceramides emerge as key players in Alzheimer's pathology but therapeutic targeting faces hurdles
• Obesity in older adults lowers Alzheimer's risk while underweight status and weight loss increase it
• GLP-1 receptor agonists may reduce cognitive decline in type 2 diabetes patients with dementia
• Meta-analysis identifies 311 serum metabolite associations in Alzheimer's disease trajectory
• HMC3 microglial model illuminates neurodegenerative mechanisms and early therapeutic discovery
• TREM2 activation lowers amyloid plaques and tau in Alzheimer's disease animal models across twelve studies
• Adding quantitative FDG-PET interpretation improves specificity in Alzheimer's diagnosis
• Acupuncture Boosts Cognition in Alzheimer's and Mild Cognitive Impairment
• Ethanol exposure and high-fat diet may impair amyloid-beta clearance and promote oxidative stress in Alzheimer's disease
• SLE linked to 53% higher odds of cognitive impairment in meta-analysis of 7 million
• Nutrient and metabolite interventions for neurodegenerative diseases show inconsistent clinical translation
• Dog-assisted therapy significantly improves behavioral symptoms in dementia patients compared to routine care in a systematic review
• Higher EAT-Lancet diet adherence linked to lower risks of depression, anxiety, stroke, and dementia in observational cohorts
• Systematic review finds inflammatory markers elevated in Alzheimer's disease compared to healthy controls across 41 studies
• Oral Semaglutide Failed to Slow Clinical Progression in Early Alzheimer's Disease Across Global Phase 3 Trials
• Narrative review suggests music therapy may improve cognition and neuropsychiatric symptoms in cognitive impairment
• Systematic review and meta-analysis of retinal biomarkers in frontotemporal dementia and Alzheimer disease
• Review synthesizes neuroprotective potential of TCM metabolites using zebrafish models for neurological conditions
• Systematic review and meta-analysis of engineered exosomes in preclinical Alzheimer's models
• tDCS improves global cognition in Alzheimer's and MCI
• Depression linked to higher risk of progression from mild cognitive impairment to Alzheimer's disease and dementia in adults
• Narrative review links personality traits to Alzheimer's disease risk and cognitive outcomes
• Meta-analysis suggests high BMI causally increases vascular-related dementia risk via blood pressure mediation
• Meta-analysis of Mendelian randomization suggests GLP-1 receptor agonism lowers vascular dementia risk
• AI-assisted PET radiomics improves Alzheimer's diagnosis over conventional methods in meta-analysis
• Review highlights microglia-targeted therapies as emerging Alzheimer's strategy beyond amyloid
• Review of nanoparticle systems for Alzheimer's disease brain delivery challenges
• Narrative review of Alzheimer's disease without reported intervention or outcomes
• Antipsychotic use persists in hospitalized dementia patients despite intervention
• Systematic review of AI applications for protein misfolding diseases
• Meta-analysis links acute kidney injury to increased stroke, delirium, and dementia risk
• Exercise interventions significantly improve subjective sleep quality in patients with Alzheimer's disease based on meta-analysis findings
• Systematic review and meta-analysis shows increased mortality risk with antipsychotic drugs in dementia patients
• Systematic review and meta-analysis of dual-task walking in adults with dementia shows slower speed and shorter steps versus controls
• Financial compensation during recruitment did not improve consent rates for Alzheimer's disease study participants in this trial
• Narrative review of Huntington's disease highlights limited clinical validation and safety concerns
• Systematic review finds no significant impact of non-pharmaceutical interventions on behavioral outcomes or quality of life for young-onset dementia patients and caregivers
• Meta-analysis identifies new genetic loci for Alzheimer disease across diverse veteran populations
• FDA Approves Rexulti (brexpiprazole) for Agitation in Alzheimer's Dementia
• FDA Approves Auvelity (dextromethorphan/bupropion) for Major Depressive Disorder and Agitation in Alzheimer's
• Plasma p-tau217 demonstrates high diagnostic accuracy for Alzheimer's disease across diverse clinical cohorts and biomarker definitions
• Meta-analysis links loneliness to Alzheimer's disease and suicidal behavior outcomes
• Systematic review validates eDEM-CONNECTONTO ontology for dementia caregiver support tools
• Narrative review explores ferroptosis-immune crosstalk in CNS diseases as therapeutic target
• Systematic review finds cannabinoids reduce agitation in severe dementia but increase sedation risk
• Systematic review and meta-analysis of dietary restriction in Alzheimer's mouse models
• Pilot study assesses safety and feasibility of young donor plasma replacement in mild cognitive impairment
• Personalized Feature Statistics framework characterizes genetic variant effects in Alzheimer's Disease across diverse ancestries
• Framingham cohort links longitudinal brain atrophy patterns to cognitive decline and AD biomarkers in community-based participants
• Review of cross-sectional EEG study on 32-Hz stimulation in Alzheimer's disease and mild cognitive impairment
• Computational model shows individualized gamma stimulation outperforms fixed frequency in Alzheimer's simulation
• MMSE-CDR-SB residual deviation from AD pattern linked to non-AD pathologies in autopsy and clinical cohorts
• Assistive technologies for social health in dementia show limited evidence of effectiveness
• Olfactory decline associated with conversion to mild cognitive impairment and dementia in unimpaired adults
• Systematic review of PPAV11 proteomic signature shows high accuracy for Alzheimer's disease diagnosis and prognosis
• Living alone not linked to incident dementia but associated with higher institutionalization risk in a cohort of 2,269 individuals
• Review of iRBD biomarker-positive participants shows higher rates of cognitive and autonomic symptoms compared to healthy controls
• Computational neuroimaging study finds tDCS anxiety reduction linked to specific fMRI connectivity patterns in older adults
• Early-onset epilepsy associated with higher biomarker abnormality in older adults
• Meta-analysis identifies protein associations with behavioral symptoms in dementia
• Review synthesizes observational data linking earlier menopause to accelerated aging and dementia risk in postmenopausal women
• Sex hormone traits linked to Alzheimer's risk in sex-specific Mendelian randomization study
• Meta-analysis links digital exclusion to functional decline and dementia in older adults
• Systematic review and meta-analysis of Kai-xin-san in animal models of Alzheimer's disease
• CSF α-synuclein SAA detects Lewy body dementia with 95% sensitivity in multicenter cohort
• Review synthesizes genetic and environmental risk factors for dementia with Lewy bodies
• Review of MRI radiomic features aids Alzheimer's disease classification and progression modeling in 382 participants
• Semaglutide linked to lower neuropsychiatric event risk vs other diabetes drugs in observational study
• Elevated Plasma P-tau217 Associated with Cognitive Impairment Onset Up to Four Years Before in Preclinical Alzheimer's
• Rare CNV dosage associated with Alzheimer's disease risk in exome case-control study
• AI-assisted Bayesian framework identifies Alzheimer's gene pathways in single-cell RNA data
• Menopausal hormone therapy initiation around menopause linked to increased Alzheimer's risk
• Meta-analysis finds association between dentition defects and Alzheimer's disease risk
• Meta-analysis finds trivial cognitive effects of amyloid antibodies in mild Alzheimer's disease
• Narrative review examines resveratrol in Alzheimer's, Parkinson's, MS, and cerebral ischemia with noted limitations
• Mixed-methods review evaluates usability of iSupport-Malaysia for dementia caregivers in Malaysia
• FDA Approves DATSCAN (ioflupane I-123) for Striatal Dopamine Transporter Visualization in Suspected Parkinsonian Syndromes or Dementia with Lewy Bodies
• Observational review of phenoconversion rates and biomarker alignment in Parkinson's disease genetic cohorts
• Review of UK Biobank data identifies plasma protein mediators in cardiometabolic disease progression
• Literature review synthesizes Schisandra chinensis effects on gut microbiota and metabolic pathways across multiple conditions
• Observational analysis of a multi-channel blood biomarker framework for Alzheimer's amyloid detection
• Plasma proteomics profiling reveals differential protein expression in Alzheimer's and frontotemporal dementia
• Genome-wide association study identifies inverse association between HSV-1 DNA and Alzheimer's disease risk
• Nocturnal sensor signals may predict next-day agitation in dementia cohorts
• APOE epsilon4 allele frequencies vary widely across Indian populations with implications for dementia risk assessment
• Symmetry-informed inverse learning model evaluated for metastasis and Alzheimer disease detection on healthy brain MRI slices
• Review of bilingualism effects on naming performance in Catalan-Spanish speakers with cognitive impairment
• NIH News in Health issue lists items on DLD, pancreatic cancer test, air pollution, dementia medications
• Posdinemab shows linear pharmacokinetics and predicted tau reduction in Phase 1 AD study
• Systematic review summarizes complement system alterations in Alzheimer's disease pathogenesis and therapeutic potential
• Bayesian network meta-analysis evaluates antidiabetic medications and dementia risk in 4,382,897 patients
• Mini-review synthesizes dementia risk and cognitive trajectories in individuals with schizophrenia
• Brain reserve moderates AD pathology associations with cognitive function in cognitively unimpaired adults
• Plasma biomarker models show high discrimination but NPV decline in cross-cohort Alzheimer's validation
• Disability benefit take-up varied by cause of death and geography in England and Wales
• VeraBIND Tau assay predicts tau-PET positivity in older adults with high sensitivity and specificity
• Biological age acceleration linked to faster progression from cardiovascular-kidney-metabolic disease to dementia
• Narrative review examines depression-dementia relationship in aging populations
• SILA algorithm estimates tau positivity onset from PET imaging in Alzheimer's disease cohorts
• Systematic review hypothesizes vitamin D3 and A combination may mitigate neurodegeneration
• FDA Approves Ingrezza Sprinkle (valbenazine) for Tardive Dyskinesia and Chorea Associated with Huntington’s Disease
• Meta-analysis links specific TOMM40 polymorphisms to Alzheimer's disease risk in thirteen included articles
• Neuroimaging characteristics of early-onset Alzheimer's disease remain poorly elucidated compared to late-onset forms
• Frailty associated with higher odds of incident all-cause dementia and Alzheimer's disease in 835,992 participants
• Genetic correlation between kidney function and Alzheimer disease is absent in European and African ancestry cohorts
• AI speech analysis distinguishes Alzheimer's disease from controls with high accuracy in a German cohort
• Lecanemab slowed cognitive decline in ApoE4 non-carriers and heterozygotes with early Alzheimer's disease
• China's rehabilitation needs for neurological disorders increased significantly from 1990 to 2021
• 6-metabolite blood biomarkers aid differential diagnosis of Parkinson's disease versus healthy controls and other neurodegenerative conditions
• Luteolin shows neuroprotective potential in preclinical models for Alzheimer's, Parkinson's, Huntington's, and multiple sclerosis
• Active bilingualism associated with better neuropsychological function and biomarker profiles in Alzheimer's disease compared to passive bilingualism
• FDG-PET reveals dysregulated glucose metabolism as a common feature across late-onset neurodegenerative diseases with unique patterns
• Spatial coupling of enlarged perivascular spaces and white matter lesions observed across Alzheimer's disease continuum stages
• Multidomain approaches and specific supplements show promise for Alzheimer's disease prevention and management in at-risk elderly populations
• Exercise intervention improved global cognitive function in adults aged 60+ with Alzheimer's disease
• South American experts reach consensus on some dementia screening protocol elements for primary care
• Review summarizes Aβ-targeted Alzheimer's vaccine progress from failed first-generation to promising next-generation candidates
• BP variability and pulse pressure associated with cognitive decline in type 2 diabetes patients
• Dementia associated with higher advance directive completion and surrogate involvement in end-of-life care
• Systematic review finds wide variation in neurodegenerative disease prevalence among older Russian adults
• NeuroFM foundation model enables brain health profiling and dementia risk estimation from MRI
• Digital memory assessment and plasma pTau217 identify preclinical Alzheimer's disease participants at elevated risk for progression
• History of falls is associated with increased risk of future dementia in adults aged 40 years and older
• U.S. dementia death rates in 2017 were highest among non-Hispanic white persons
• Normative modeling of brain structure in healthy individuals elucidates cortical atrophy patterns in Alzheimer's disease
• Plasma p-tau217 shows no correlation with age or comorbidity in adolescents
• Observational study links frailty index and neuroimaging markers to dementia risk in UK Biobank cohort
• Caregivers of dementia patients report insufficient support for nighttime agitation
• Active bilingualism associated with delayed symptom onset in Alzheimer's disease clinical stages
• Bilingualism associated with different gray matter patterns in Alzheimer's variants but comparable cognition
• Observational study derives six-stage amyloid-tau PET model for Alzheimer's disease progression
• Qualitative study identifies systemic barriers and caregiver burden in Latino dementia care navigation
• Methodological analysis questions predictive value of plasma p-tau217 disease clocks for Alzheimer's onset
• Meta-analysis finds 58% prevalence of dementia-relevant MRI abnormalities in LMIC patients
• Hormone therapy shows no significant effect on Alzheimer's biomarker changes in postmenopausal women
• Pilot RCT: Telehealth palliative care model may reduce hospital visits in dementia patients
• Plant-based diet adherence associated with lower cognitive impairment risk in meta-analysis
• Meta-analysis finds distinct fMRI activation patterns in MCI and Alzheimer's disease during cognitive tasks
• Review organizes pharmacological strategies targeting gut-brain axis for neurological and psychiatric disorders
• Body weight variability associated with increased dementia risk in meta-analysis of cohort studies
• Ketamine shows cognitive effects in animal models but cognitive worsening in human Huntington's disease study
• Meta-analysis finds Icariin improves cognition in Alzheimer's animal models at 68 mg/kg dose
• Anosognosia and Theory of Mind Deficits Independently Associated with Caregiver Distress in Dementia
• mHealth program reduces caregiver burden for dementia-diabetes caregivers in RCT