Systematic review finds cannabinoids reduce agitation in severe dementia but increase sedation risk
Cannabinoids Calm Agitation But Not All Dementia Symptoms
This systematic review and meta-analysis evaluated cannabinoids for neuropsychiatric symptoms in persons with dementia. The analysis include…
Cannabinoids may calm agitation in dementia patients but do not fix all behavioral problems and can make people sleepy.
Framingham cohort links longitudinal brain atrophy patterns to cognitive decline and AD biomarkers in community-based participants
Brain shrinkage patterns predict Alzheimer's risk in older adults
This community-based cohort study of 300 participants from the Framingham Heart Study analyzed longitudinal brain atrophy patterns using MRI…
A study of 300 older adults found specific brain shrinkage patterns that strongly predict Alzheimer's disease and worse thinking skills.
Assistive technologies for social health in dementia show limited evidence of effectiveness
Many dementia technologies are adaptable, yet few have proven evidence for social health benefits
This umbrella review of 28 reviews published between 2007 and 2024 examined assistive technologies for social health in people with dementia…
Many tools for dementia claim to be adaptable, yet robust evidence for social health benefits is still limited.
Living alone not linked to incident dementia but associated with higher institutionalization risk in a cohort of 2,269 individuals.
Living Alone Does Not Raise Dementia Risk But Increases Care Needs
This French clinic-based cohort study followed 2,269 individuals with cognitive complaints or mild cognitive impairment for a median of 5 ye…
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Olfactory decline associated with conversion to mild cognitive impairment and dementia in unimpaired adults.
Losing your sense of smell might warn of memory loss
This retrospective longitudinal analysis of 922 cognitively unimpaired individuals found olfactory decline associated with conversion to mil…
Losing your sense of smell could warn of memory loss years before symptoms appear in older adults seeking help.
Early-onset epilepsy associated with higher biomarker abnormality in older adults
Older Adults With Epilepsy Face Higher Dementia Risk, New Brain Tests Reveal
This observational study of 84 older adults with focal epilepsy examined AT(N) biomarker profiles and cognitive associations. The analysis f…
New brain blood tests show most older adults with epilepsy have signs of dementia risk, even without symptoms.
Meta-analysis identifies protein associations with behavioral symptoms in dementia
New Brain Clues Explain Dementia Mood Symptoms
This meta-analysis of brain proteomic profiles from 376 donors synthesized associations between specific proteins and behavioral and psychol…
Anxiety and mood swings in dementia may stem from specific brain proteins, offering real hope for future treatments that target the root cau…
Review synthesizes observational data linking earlier menopause to accelerated aging and dementia risk in postmenopausal women.
Early Menopause Tied to Faster Brain Aging
This narrative review synthesizes data from the UK Biobank (n=15,012) and the Women's Health Initiative Long Life Study (n=1,210). The autho…
Women who go through menopause early may face faster brain aging, linked to higher dementia risk, a new analysis of over 15,000 women reveal…
Menopausal hormone therapy initiation around menopause linked to increased Alzheimer's risk
Hormone Therapy and Dementia: The Truth About Timing
This systematic review and meta-analysis of 213,678 menopausal women found that initiating systemic menopausal hormone therapy (MHT) around …
Many women look to hormone therapy to ease the hot flashes and mood swings of menopause.
Mixed-methods review evaluates usability of iSupport-Malaysia for dementia caregivers in Malaysia
New Dementia Tool Speaks Your Language
This mixed-methods review assesses the iSupport-Malaysia platform, a culturally adapted multimedia web-based psychoeducational intervention …
This new tool could finally bridge the gap between global dementia research and the real-world needs of Malaysian families.
Nocturnal sensor signals may predict next-day agitation in dementia cohorts
Sleep Sensors May Predict Dementia Agitation Before It Starts
This cohort study used under-mattress sensors in long-term care and home cohorts (N=55 and N=18) to assess nocturnal signals for predicting …
New sleep sensors can spot signs of dementia agitation before it starts, helping caregivers prepare for difficult days.
Bayesian network meta-analysis evaluates antidiabetic medications and dementia risk in 4,382,897 patients.
Could diabetes drugs lower dementia risk, or raise it for some patients?
This Bayesian network meta-analysis synthesized data from 28 articles involving 4,382,897 patients to assess antidiabetic drugs and dementia…
Insulin and metformin cut dementia risk, but DPP4 inhibitors may double Alzheimer's risk compared to SGLT2 drugs in diabetes patients.