Mode
Text Size
Log in / Sign up

Delirium occurs in 18.5% of hospitalized heart failure patients, meta-analysis findsDelirium Strikes 1 in 5 Hospitalized Heart Failure Patients

AI-generated summary of the cited source, checked by automated accuracy review. How we work

Key Takeaway
Consider screening for delirium in hospitalized heart failure patients, given the 18.5% pooled incidence.

This meta-analysis pooled data from 17,944 hospitalized heart failure patients to estimate the incidence of delirium. The primary outcome was the incidence of delirium, reported as 18.5% with a 95% confidence interval of 13.1% to 24.6%. The analysis revealed very high heterogeneity (I2 = 98.651), suggesting substantial variability across included studies, which limits the precision and generalizability of the pooled estimate.

The review did not report on secondary outcomes, safety data, or specific interventions or comparators. The authors noted high heterogeneity as a key limitation, and no information was provided on follow-up duration, funding, or conflicts of interest.

Clinically, these findings underscore that delirium is a frequent complication in hospitalized heart failure patients, affecting nearly 1 in 5. However, the high heterogeneity warrants cautious interpretation, and further research is needed to identify risk factors and preventive strategies. The review does not provide data on outcomes or management of delirium in this population.

How this fits prior evidence

This meta-analysis extends prior coverage on heart failure by quantifying a common complication. While prior items focused on treatments (digoxin, finerenone) and monitoring (telemedicine), this review addresses a gap by highlighting delirium as a frequent comorbidity in hospitalized patients. The 18.5% incidence rate adds a new dimension to heart failure management, complementing earlier findings on immune-stromal imbalance and engineered vesicles that lacked clinical data.

Delirium is a serious complication for hospitalized heart failure patients, affecting nearly one in five, according to a new meta-analysis. Researchers combined data from multiple studies involving 17,944 patients and found that the overall rate of delirium was 18.5%. This means that about 1 out of every 5 patients with heart failure may experience confusion, agitation, or other symptoms of delirium while in the hospital.

The analysis, which included studies from various hospitals, showed a wide range of delirium rates across different patient groups. Some studies reported rates as low as 13%, while others found rates as high as 25%. This variation may be due to differences in patient age, severity of heart failure, or how delirium was diagnosed.

Delirium is not just a temporary confusion; it can lead to longer hospital stays, increased risk of falls, and even higher death rates. For heart failure patients, who already have a weakened heart, the added stress of delirium can be especially dangerous. The study's authors note that there was high variability among the studies, which means the true rate could be different in specific hospitals or patient populations.

Despite these limitations, the findings underscore the need for hospitals to screen for delirium in heart failure patients and take steps to prevent it. Simple measures like keeping patients oriented, ensuring they get enough sleep, and avoiding certain medications may help reduce the risk.

What this means for you:
About 18.5% of hospitalized heart failure patients develop delirium, a serious but often preventable complication.

Common questions

What is delirium?

Delirium is a sudden change in mental state that causes confusion, agitation, and trouble focusing. It often comes on quickly during a hospital stay and can make recovery harder.

How common is delirium in heart failure patients?

According to this analysis, about 18.5% of hospitalized heart failure patients develop delirium. The rate could be as low as 13.1% or as high as 24.6% based on the confidence interval.

What should I do if I notice confusion in a loved one with heart failure?

Tell the hospital staff right away. Delirium is a medical emergency that needs prompt attention. The care team can check for causes and help manage symptoms.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedJun 2026
View Original Abstract ↓
ObjectiveThe reported incidence of delirium in hospitalized heart failure (HF) patients in current studies was inconsistent. The objective of this study was to conduct a meta-analysis to quantify the incidence of delirium in hospitalized HF patients.MethodsPubMed, The Cochrane Library, Web of Science, Embase, Ovid Medline, CINAHL, CNKI, WanFang Database, VIP, and SinoMed were systematically searched from inception to 18 May 2026. Two researchers independently screened the literature, extracted data, and evaluated the risk of bias. Stata 18.0 was used for statistical analysis. The meta-analysis employed a random-effects model with the DerSimonian–Laird method to pool the incidence of delirium in hospitalized HF patients. Subgroup analysis, sensitivity analysis, and meta-regression analysis were undertaken to identify the sources of heterogeneity.ResultsUltimately, 17 studies met the inclusion criteria, including a total of 17,944 HF patients. The meta-analysis results showed that the pooled incidence of delirium in hospitalized HF patients was 18.5% (95% confidence interval: 13.1%–24.6%; I2 = 98.651, P 
Free Newsletter

Clinical research that matters. Delivered to your inbox.

Join thousands of clinicians and researchers. No spam, unsubscribe anytime.