Mode
Text Size
Log in / Sign up

Poor sleep quality associated with higher left ventricular mass in African/Caribbean and South Asian adultsDoes poor sleep make your heart muscle thicker in some groups but not others?

AI-generated summary of the cited source, checked by automated accuracy review. How we work

Key Takeaway
Consider sleep quality assessment in cardiovascular risk evaluation for African/Caribbean and South Asian patients.

A cohort study within the Southall and Brent Revisited (SABRE) study examined 1,284 tri-ethnic participants (Europeans, South Asians, African/African-Caribbean) to assess associations between self-reported sleep quality and left ventricular structure. Participants with poorer sleep quality were compared to those with very good sleep quality, with left ventricular mass indexed to height1.7 (LVMi) as the primary outcome.

Overall, poorer sleep quality was associated with higher LVMi (4.8 g/(m1.7*unit sleep score); 95% CI 1.4, 8.2; p=0.006). However, this association showed significant ethnic variation. In African/African-Caribbean participants, the association was strongest (9.1 g/(m1.7*unit sleep score); 95% CI 1.3, 16.8; p=0.023), followed by South Asians (5.8 g/(m1.7*unit sleep score); 95% CI 0.5, 11.0; p=0.031). No significant association was found in Europeans (1.9 g/(m1.7*unit sleep score); 95% CI -3.5, 7.3; p=0.493).

Safety and tolerability data were not reported. Key limitations include the observational design, which cannot establish causality, and the authors' note that ethnic differences in the relationship between sleep and left ventricular structure have not been studied previously. The association between sleep quality and left ventricular structure remains poorly understood.

For practice, this study suggests sleep quality may be a modifiable factor contributing to ethnic disparities in cardiovascular risk, particularly in African/Caribbean and South Asian populations. However, clinicians should interpret these findings cautiously as associations only, with causality not established.

Imagine your heart as a pump that works hard every day. Sometimes, things like stress or bad habits can change its shape over time. This research team studied 1,284 people from three different backgrounds: Europeans, South Asians, and African/African-Caribbean people. They wanted to know if sleeping poorly makes the heart muscle grow thicker, a sign of strain. They compared people with very good sleep to those with poor sleep.

The results showed a clear difference in the South Asian and African/African-Caribbean groups. In these communities, people who slept poorly had significantly thicker heart muscle walls than those who slept well. However, in the European group, the link between poor sleep and a thicker heart was not convincing. The study could not prove that bad sleep causes this change, only that the two things happen together.

This finding is important because it shows that health risks from poor sleep might not look the same for everyone. We have not studied these ethnic differences before, so we must be careful not to assume the same rules apply to all people. While this could mean better sleep helps protect the heart for some groups, we need more research to understand exactly why this happens.

What this means for you:
Poor sleep links to thicker heart muscle in South Asian and African/African-Caribbean groups, but not Europeans.

Study Details

Study typeCohort
Sample sizen = 1,284
EvidenceLevel 3
PublishedApr 2026
View Original Abstract ↓
Abstract Background: Poor sleep quality is associated with increased cardiovascular risk, although its relationship with left ventricle (LV) structure is poorly understood and ethnic differences in the relationship between sleep and LV structure have not been studied. We investigated the association between poor sleep quality and LV structure in a tri-ethnic cohort. Methods: A total of 1284 participants were analysed from the Southall and Brent Revisited (SABRE) study (age=49.9{+/-} 6.2y; male 75.9%, Europeans (EU)=615, South Asians (SA)=457, African/African-Caribbean (AC)=212). A composite sleep quality score was calculated, and LV structure was measured using echocardiography. Associations between sleep quality and LV mass indexed to height1.7 (LVMi), relative wall thickness (RWT) and LV end-diastolic volume indexed to height1.7 (LVEDVi) were estimated using multivariable linear regression with adjustment for demographic and lifestyle factors across three models. Analyses were performed in the whole cohort and stratified by ethnicity. Results: Compared with those who reported very good sleep quality, participants with poorer sleep quality had higher LVMi (4.8 (95% CI 1.4; 8.2)g/(m1.7*unit sleep score); p=0.006). When stratifying by ethnicity, the association between sleep quality and LVMi was unconvincing in EU (1.9(-3.5, 7.3)g/(m1.7*unit sleep score); p=0.493), whereas poor sleep was associated with higher LVMi in AC and SA participants (9.1(1.3;16.8)g/(m1.7*unit sleep score); p=0.023 and 5.8(0.5;11.0)g/(m1.7*unit sleep score); p=0.031 respectively). Conclusions: Poor sleep quality is associated with higher LVMi in older African/African-Caribbeans and South Asians, but not in Europeans. This may contribute to cardiovascular risk. Keywords: sleep, left ventricle, hypertrophy, remodelling
Free Newsletter

Clinical research that matters. Delivered to your inbox.

Join thousands of clinicians and researchers. No spam, unsubscribe anytime.