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Breviscapine Add-On May Improve Angina Response in Coronary Heart DiseaseBreviscapine May Help Heart Disease Patients With Angina Symptoms

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Key Takeaway
Breviscapine add-on improved total effective rate in coronary heart disease with angina, but safety data are lacking.

A meta-analysis examined whether breviscapine, given alone or as an add-on, improves outcomes in patients with coronary heart disease and angina pectoris compared with conventional therapy.

The primary outcome was total effective rate. Pooled results showed a significant benefit favoring breviscapine, with a risk ratio of 1.20 and a 95% confidence interval of 1.14 to 1.26. This suggests a consistent direction of effect across the included studies.

However, the analysis did not report safety outcomes such as adverse events, serious adverse events, discontinuations, or tolerability. No secondary outcomes were listed, and details on sample size, setting, follow-up duration, funding, and conflicts of interest were not provided.

Because the evidence is limited to the total effective rate and safety remains uncharacterized, these findings should be interpreted cautiously. Clinicians should weigh the potential symptomatic benefit against the absence of safety data when considering breviscapine for this population.

A new analysis looked at whether breviscapine helps people with coronary heart disease and angina. This is a condition where the heart does not get enough blood flow, causing chest pain.

The researchers combined results from multiple studies. They compared breviscapine, given alone or with usual treatment, to usual treatment alone. The main measure was how many people improved overall.

People who took breviscapine were about 20% more likely to see improvement compared to those who only received usual care. The analysis found this result was consistent across the studies.

However, the analysis did not report information about side effects, serious problems, or how many people stopped treatment. It also did not say how long patients were followed or what other outcomes were measured.

Because safety data is missing, patients and doctors should be careful. More research is needed to fully understand the benefits and risks of breviscapine for heart disease and angina.

What this means for you:
Breviscapine may improve overall treatment success for heart disease and angina, but safety data is lacking.

Common questions

What is breviscapine used for?

Breviscapine is being studied for coronary heart disease with angina. In this meta-analysis, it was given alone or added to conventional therapy. The review found a higher total effective rate with breviscapine, but it did not report what conditions or symptoms improved. Always ask your doctor if breviscapine is right for you.

How effective is breviscapine for angina?

The meta-analysis reported a risk ratio of 1.20 (95% CI 1.14 to 1.26) for total effective rate. That means people taking breviscapine were about 20 percent more likely to be classified as responding to treatment. However, the review did not describe how response was measured or how long patients were followed.

Is breviscapine safe? What are the side effects?

The provided analysis does not report any safety information. There are no details on side effects, serious adverse events, or discontinuations. Without this information, it is not possible to say whether breviscapine is safe. Talk with your doctor about any concerns before starting or changing treatment.

Who was included in this breviscapine meta-analysis?

The review included patients with coronary heart disease and angina pectoris. The total number of patients was not reported. The studies compared breviscapine, alone or as an add-on, with conventional therapy. No other details about the participants, such as age or other health conditions, were provided.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedSep 2026
View Original Abstract ↓
BackgroundCoronary heart disease is a leading cause of cardiovascular mortality. Residual angina pectoris often persists despite long-term treatment. Breviscapine, a plant-derived flavonoid, exhibits multi-target cardiovascular effects; however, its clinical role requires systematic evaluation.ObjectiveThis meta-analysis aims to comprehensively assess the efficacy and safety of Breviscapine for angina pectoris in coronary heart disease.MethodsDatabases were systematically searched for relevant randomized controlled trials (RCTs) up to December 2024. Two researchers independently performed study selection, data extraction, and risk-of-bias assessment. Data were analyzed using RevMan 5.4, employing a random-effects model for all meta-analyses.ResultsA total of 29 RCTs were included. Breviscapine (alone or add-on) demonstrated significant benefits over conventional therapy in: (1) Total effective rate (13 studies, RR = 1.20, 95% CI 1.14–1.26, p 
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