Retrospective cohort finds inverse triglyceride relationship with mortality in left main coronary artery disease
This retrospective cohort study included 2,778 patients with left main coronary artery disease undergoing percutaneous coronary intervention at a single-center setting. The investigation examined triglyceride levels as the primary exposure, stratifying patients by different triglyceride levels using an optimal cutoff. Follow-up duration was a mean 47.4 ± 30.3 months. The study design focused on observational associations rather than randomized comparisons.
The analysis identified a linear inverse relationship between triglyceride levels and all-cause mortality. Specifically, the low-TG group had significantly higher all-cause mortality compared to the high-TG group. Absolute numbers showed 351 deaths (12.6%) overall. Mortality rates were 17.2% in the low-TG group (n=564) versus 11.5% in the high-TG group (n=2214). Secondary outcomes included cardiovascular death, myocardial infarction, stroke, stent thrombosis, and target vessel revascularization.
Safety data regarding adverse events, serious adverse events, and discontinuations were not reported. The study examined associations and did not establish causation. No limitations or practice relevance were reported in the source data. Clinicians should note that outcomes beyond mortality were not explicitly detailed in the results provided. P-values for the primary comparison were not reported. These factors limit direct clinical application.
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