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Pulsed field ablation shows similar efficacy to radiofrequency ablation for paroxysmal AFIs pulsed field ablation better for AFib? New study finds it matches standard treatment

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Key Takeaway
Consider PFA as potentially comparable to RFA for paroxysmal AF, with similar efficacy and a numerically safer profile.

This multicenter randomized controlled trial compared pulsed field ablation (PFA) using a pentaspline catheter against radiofrequency ablation (RFA) following the CLOSE protocol in 289 patients aged 18-80 years with symptomatic, drug-resistant paroxysmal atrial fibrillation. The primary outcome was single-procedure success at 12 months, defined as absence of ≥30-second atrial arrhythmia recurrence, cardioversion, class I/III antiarrhythmic drug resumption after a 2-month blanking period, or any repeat ablation.

For efficacy, there was no significant difference between groups: PFA achieved 77.2% success (112/145) compared to 77.6% (111/143) with RFA. The adjusted difference was 0.9% with a 95% confidence interval of -8.2% to 10.1% (P=0.84), indicating PFA was not superior to RFA. Regarding safety, procedure-related serious adverse events occurred in 3.4% of PFA patients (5 events) versus 7.6% of RFA patients (11 events), representing a difference of -3.3% (95% CI -8.4% to 1.8%).

Key limitations include the study being reported only as an abstract, which typically provides limited methodological details. Adverse event reporting beyond procedure-related serious events was not reported, and discontinuation rates and tolerability data were unavailable. The confidence intervals for both efficacy and safety outcomes include no difference, meaning the observed numerical advantages for PFA in safety could be due to chance.

For practice, this trial suggests PFA may achieve similar 12-month efficacy outcomes as established RFA techniques in patients with drug-resistant paroxysmal AF. The numerically lower serious adverse event rate with PFA warrants attention but requires confirmation in larger studies with comprehensive safety reporting. Clinicians should interpret these findings cautiously given the abstract-only publication and need for longer-term data.

When medication fails to control paroxysmal atrial fibrillation—a type of irregular heartbeat that comes and goes—doctors often turn to a procedure called ablation to scar the heart tissue causing the problem. A new study directly compared two ways to do this: the newer pulsed field ablation (PFA) and the established radiofrequency ablation (RFA). The trial followed 289 patients across Europe for a year after their single procedure.

The key finding was that both methods were equally effective. About 77% of patients in each group were free from significant atrial arrhythmia recurrence after 12 months. The numbers were nearly identical: 112 out of 145 patients with PFA and 111 out of 143 with RFA. The statistical analysis confirmed there was no meaningful difference in success rates.

On safety, the study observed fewer serious procedure-related events with the newer PFA technique—3.4% versus 7.6% with RFA. However, this difference wasn't statistically significant, meaning it could be due to chance. The research, presented as a journal abstract, doesn't report on other adverse events or long-term outcomes beyond one year. While this adds evidence that PFA is a viable alternative, it doesn't establish superiority over the current standard approach.

What this means for you:
Two ablation techniques for AFib show similar success; newer method had fewer serious complications in this study.

Study Details

Study typeRct
Sample sizen = 145
EvidenceLevel 2
Follow-up960.0 mo
PublishedApr 2026
View Original Abstract ↓
BACKGROUND AND AIMS: This trial compared single-procedure efficacy and safety of pulsed field ablation (PFA) vs radiofrequency ablation (RFA) in patients with drug-resistant paroxysmal atrial fibrillation (AF). METHODS: BEAT PAROX-AF is a European, multicentre, open-label, randomized, controlled, superiority trial conducted across nine European sites. Eligible patients (aged 18-80 years) with symptomatic, drug-resistant paroxysmal AF were randomized (1:1) to either PFA (pentaspline) or RFA following the CLOSE protocol (contact force sensing catheter and electro-anatomical mapping system). The primary endpoint was the single-procedure success rate after 12 months defined as the absence of ≥30 s atrial arrhythmia recurrence, cardioversion, class I/III antiarrhythmic drug resumption after a 2-month blanking period, or any repeat ablation. RESULTS: From December 2021 to January 2024, 292 patients were randomized and 289 (median age 63.5 years, 58% male) were analysed (PFA n = 145, RFA n = 144). Single-procedure success at 12 months was 112/145 (77.2%) in the PFA group and 111/143 (77.6%) in the RFA group (adjusted difference 0.9%; 95% confidence interval -8.2% to 10.1%; P = .84). Procedure-related serious adverse events occurred in 5 (3.4%) PFA vs 11 (7.6%) RFA patients (difference -3.3% [-8.4%, 1.8%]). No deaths, persistent phrenic palsy nor stroke occurred. In the RFA group, two patients had pulmonary vein stenosis >70% and 12 > 50%, two tamponades, and one oesophageal bleed. CONCLUSIONS: This randomized trial performed in patients with paroxysmal AF did not demonstrate superior efficacy of single-shot PFA vs point-by-point RFA using the CLOSE protocol regarding single-procedure freedom from atrial arrhythmias, despite fewer safety events being observed in this study with PFA.
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