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Paroxysmal Atrial Fibrillation

Part of Atrial Fibrillation

4 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Paroxysmal Atrial Fibrillation

46 trials tracked for Paroxysmal Atrial Fibrillation: 6 in phase 3 or 4 and 2 with published results. The most-cited published study has 211 citations.

46Trials tracked
6Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 3 Phase 3 3 Phase 2 2 Other / NA 38
  1. Phase 3 HeartLight Ablation in Patients With Paroxysmal Atrial Fibrillation (PAF) Completed · 211 cited
  2. Phase 4 Evaluation of VISITAG SURPOINT™ Module With External Processing Unit (EPU) Completed · 27 cited
  3. Phase 4 NAVISTAR® THERMOCOOL® Catheter Post Approval Registry Completed
  4. Phase 4 Ablation of the Pulmonary Veins for Paroxysmal Afib Completed
  5. Phase 3 Clinical Study of the CardioFocus Endoscopic Ablation System for the Treatment of Symptomatic AF Completed
  6. Phase 3 A Clinical Study of the Arctic Front Cryoablation Balloon for the Treatment of Paroxysmal Atrial Fibrillation Completed
Show 40 more trials
  1. Phase 2 REVOLUTION (WFCC-133) - Treatment of Paroxysmal Atrial Fibrillation Completed
  2. Phase 2 Clinical Study of the CardioFocus Endoscopic Ablation System - Adaptive Contact (EAS-AC) for the Treatment of Symptomatic Atrial Fibrillation Completed
  3. N/A Clinical Study for Safety and Acute Performance Evaluation of the THERMOCOOL SMARTTOUCH® SF-5D System Used With Fast Ablation Mode in Treatment of Patients With Paroxysmal Atrial Fibrillation. Completed
  4. N/A AF Septal Pacing (Clinical Investigation Plan) Completed
  5. N/A LSI (Lesion Index) Workflow Observational Study Completed
  6. N/A Cryoballoon PVI With PWI Versus PVI Alone In Patients With PAF Completed
  7. N/A TactiSense IDE Trial of TactiCath SE for Paroxysmal Atrial Fibrillation Completed
  8. N/A TactiFlex Paroxysmal Atrial Fibrillation IDE Trial Completed
  9. N/A Randomized Evaluation of Redo Ablation Procedures of Atrial Fibrillation With FIRM Guided Procedures Completed
  10. N/A A Safety and Feasibility Study of the FARAPULSE Endocardial Ablation System to Treat Paroxysmal Atrial Fibrillation Completed
  11. N/A A Study Assessing Arrhythmia Mapping With the Multi-Electrode OPTRELL™ Mapping Catheter Completed
  12. N/A The FARAPULSE FARA-Freedom Trial Completed
  13. N/A Evaluation of QDOT MICRO™ Catheter for Pulmonary Vein Isolation in Subjects With Paroxysmal Atrial Fibrillation Completed
  14. N/A PEFCATII Expanded Safety and Feasibility Study of the FARAPULSE Endocardial Multi Ablation System to Treat Paroxysmal Atrial Fibrillation Completed
  15. N/A TactiCath Contact Force Ablation Catheter Study for Atrial Fibrillation Completed
  16. N/A DiamondTemp™ Ablation System for the Treatment of Paroxysmal Atrial Fibrillation Completed
  17. N/A A Study Assessing Arrhythmia Mapping With a Globe-Shaped, High-Density, Multi-Electrode Mapping Catheter Completed
  18. N/A A RWS of the FARAPULSE in A Chinese Population With PAF Completed
  19. N/A Irrigated Ablation System Evaluation for Atrial Fibrillation (AF) Completed
  20. N/A POLARx™ Cardiac Cryoablation System Post Market Clinical Study (POLAR SMART) Completed
  21. N/A Efficacy of Personalized Exercise Program and Trimetazidine in Rehabilitation of Patients After RFA of AF Completed
  22. N/A FIRE AND ICE Re-Ablations (Retrospective Data Collection) Completed
  23. N/A A Single Arm Pilot Study of Pulsed Field Ablation in the Treatment of Paroxysmal Atrial Fibrillation Completed
  24. N/A Effect of Treatment of Sleep Apnea in Patients With Paroxysmal Atrial Fibrillation Completed
  25. N/A Prospective Evaluation of Open Irrigated Ablation Catheters With High Resolution Mapping to Treat Paroxysmal Atrial Fibrillation Completed
  26. N/A Navi-Star Thermo-Cool Catheter For Ablation of Atrial Fibrillation Completed
  27. N/A TactiCath® Contact Force Ablation Catheter Study for Atrial Fibrillation Post Approval Study Completed
  28. N/A Clinical Evaluation of the StablePoint Catheter and Force Sensing System for Paroxysmal Atrial Fibrillation Completed
  29. N/A HD Mapping of Atrial Fibrillation in Asia Pacific Completed
  30. N/A Electrical Coupling Information From The Rhythmia HDx System And DirectSense Technology In Subjects With Paroxysmal Atrial Fibrillation Completed
  31. N/A Automated Assessment of PVI Using a Novel EP Recording System Completed
  32. N/A IMPACT: A Safety and Feasibility Study of the IOWA Approach Cardiac Ablation System Completed
  33. N/A Boston Scientific's Cryoballoon in the Treatment of Symptomatic Drug Refractory Paroxysmal Atrial Fibrillation Completed
  34. N/A Individualized Studies of Triggers of Paroxysmal Atrial Fibrillation Completed
  35. N/A IMPULSE: A Safety and Feasibility Study of the IOWA Approach Endocardial Ablation System to Treat Atrial Fibrillation Completed
  36. N/A A Feasibility Study to Evaluate the Effect of Concomitant Renal Denervation and Cardiac Ablation on AF Recurrence Completed
  37. N/A The FARAPULSE ADVENT PIVOTAL Trial PFA System vs SOC Ablation for Paroxysmal Atrial Fibrillation Completed
  38. N/A A Study of Intracardiac Ultrasound With the NUVISION NAV Ultrasound Catheter Completed
  39. N/A High-Density (HD) Wave Mapping in Subjects With Atrial Fibrillation as a Predictor of Recurrence After a Single Ablation Procedure Using a PVI-Only Strategy Completed
  40. N/A Multi-electrode Radiofrequency Balloon Catheter Use for the Isolation of the Pulmonary Veins. Completed

Showing the 46 most-cited and recently-updated of 46 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Atrial Fibrillation

Related studies from across the Atrial Fibrillation family.

SGLT2 inhibitors provide robust prognostic benefits in heart failure with inconsistent results in post-myocardial infarction settings
Cardiology Sys. Review
SGLT2 inhibitors provide robust prognostic benefits in heart failure with inconsistent results in post-myocardial infarction settings SGLT2 inhibitors show promise for heart failure and diabetes
This narrative review examines the cardiovascular and metabolic effects of SGLT2 inhibitors, specifically empagliflozin and dapagliflozin. T…
New evidence shows how SGLT2 inhibitors may protect the heart and manage risks for patients with type 2 diabetes and heart failure.
Incidental arrhythmia findings on ambulatory ECG vary widely in adults without prior atrial fibrillation
Cardiology Meta-analysis
Incidental arrhythmia findings on ambulatory ECG vary widely in adults without prior atrial fibrillation Hidden heart rhythm problems found in up to 96% of adults
This systematic review and meta-analysis of 136,344 community-based adults without prior atrial fibrillation found that the prevalence of in…
A review of 136,344 adults found hidden heart rhythm issues in up to 96% of people without known atrial fibrillation.
Renal denervation combined with pulmonary vein isolation increases freedom from atrial fibrillation risk in resistant hypertension patients
Cardiology Meta-analysis
Renal denervation combined with pulmonary vein isolation increases freedom from atrial fibrillation risk in resistant hypertension patients Renal denervation may help resistant hypertension patients with heart issues
This systematic review and meta-analysis evaluated renal denervation in patients with resistant hypertension. The pooled analysis included 8…
A meta-analysis suggests renal denervation improves heart and sleep markers in patients with resistant hypertension, though larger trials ar…
Hypertension history associates with 2.22-fold higher cognitive impairment risk in AF patients
Cardiology Meta-analysis
Hypertension history associates with 2.22-fold higher cognitive impairment risk in AF patients High blood pressure history doubles dementia risk in atrial fibrillation patients
This systematic review and meta-analysis of observational studies found that a history of hypertension is associated with an increased risk …
A history of high blood pressure is linked to a much higher risk of cognitive impairment in people with atrial fibrillation, according to a …
Left atrial appendage occlusion and NOACs reduce mortality compared with warfarin in atrial fibrillation
Cardiology Meta-analysis
Left atrial appendage occlusion and NOACs reduce mortality compared with warfarin in atrial fibrillation LAAO, low-dose NOACs beat warfarin for atrial fibrillation survival
A network meta-analysis compared left atrial appendage occlusion (LAAO), low-dose NOACs, standard-dose NOACs, and warfarin in non-valvular a…
For people with atrial fibrillation, warfarin may be the worst option for survival. New analysis finds LAAO and NOACs outperform it.
Pulsed-field ablation shows no significant AKI difference versus radiofrequency ablation in AF
Cardiology Meta-analysis
Pulsed-field ablation shows no significant AKI difference versus radiofrequency ablation in AF Pulsed-field ablation shows similar kidney risk as radiofrequency ablation
This systematic review and meta-analysis of 3,843 patients found no significant difference in acute kidney injury (AKI) between pulsed-field…
A large review found no major difference in kidney injury risk between two heart rhythm treatments, though one method showed slightly higher…
Discontinuing oral anticoagulation after AF ablation reduces bleeding without increasing thromboembolic risk
Cardiology Meta-analysis
Discontinuing oral anticoagulation after AF ablation reduces bleeding without increasing thromboembolic risk Stopping blood thinners after heart rhythm repair cuts bleeding risk without raising stroke danger
This systematic review and meta-analysis evaluated patients who stopped versus continued oral anticoagulation following atrial fibrillation …
A massive analysis shows stopping blood thinners after heart rhythm repair cuts bleeding risk without raising stroke danger for many patient…
Narrative review on atrial fibrillation and depression highlights bidirectional links and integrated care needs
Psychiatry Sys. Review
Narrative review on atrial fibrillation and depression highlights bidirectional links and integrated care needs Depression and heart rhythm problems may worsen each other
This narrative review synthesizes evidence on the bidirectional relationship between atrial fibrillation and depression. It suggests depress…
A new review suggests depression and atrial fibrillation can fuel each other, making it vital to screen for both conditions together.
LAAC shows noninferior efficacy and reduced bleeding versus NOACs in non-valvular AF
Cardiology RCT
LAAC shows noninferior efficacy and reduced bleeding versus NOACs in non-valvular AF New data shows left atrial appendage closure offers bleeding safety for some adults with atrial fibrillation
This meta-analysis of RCTs in adults with non-valvular AF found percutaneous left atrial appendage closure (LAAC) achieved noninferiority fo…
A large review of trials found that closing the heart appendage reduced bleeding compared to blood thinners. However, stroke risk trends wer…
Edoxaban trough concentration and PT predict major bleeding in very old AF patients
Cardiology RCT
Edoxaban trough concentration and PT predict major bleeding in very old AF patients Blood thinner levels linked to bleeding in very old patients
This post hoc analysis of the ELDERCARE-AF RCT included 427 very old Japanese patients with atrial fibrillation and high bleeding risk. High…
Higher edoxaban levels in the blood may increase bleeding risk in patients 80 and older with atrial fibrillation.
Review links metabolic syndrome to 1.5 to 2 times higher atrial fibrillation risk
Cardiology Sys. Review
Review links metabolic syndrome to 1.5 to 2 times higher atrial fibrillation risk Metabolic syndrome raises atrial fibrillation risk by 1.5 to 2 times
This narrative review examines the association between metabolic syndrome and atrial fibrillation. The authors synthesize evidence suggestin…
Metabolic syndrome increases the risk of developing atrial fibrillation by 1.5 to 2 times, a finding that could help doctors target preventi…
Editorial argues emergency physicians are key to AF heart teams
Cardiology Guideline
Editorial argues emergency physicians are key to AF heart teams Emergency doctors key to atrial fibrillation care, editorial says
This editorial argues that emergency physicians are indispensable members of atrial fibrillation heart teams. They enhance integration of ac…
An editorial argues emergency physicians should be core members of AF heart teams to improve care coordination and outcomes.

Questions about Paroxysmal Atrial Fibrillation

Are there differences in success rates between pulsed field and radiofrequency ablation?

Pulsed field ablation (PFA) and radiofrequency ablation (RFA) have similar success rates for paroxysmal AF, but PFA may have a different safety profile.

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Can lifestyle interventions improve quality of life after paroxysmal AF ablation?

Yes, nurse-led lifestyle interventions (exercise, diet, medication adherence, psychological support) significantly improve quality of life after paroxysmal AF ablation, based on randomized trial evidence.

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Does pulsed field ablation work as well as radiofrequency ablation?

Yes, pulsed field ablation (PFA) works as well as radiofrequency ablation (RFA) for treating paroxysmal atrial fibrillation, with similar success rates and a possibly lower risk of serious complications.

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What is the risk of atrial tachycardia during radiofrequency ablation?

About 13% of patients develop atrial tachycardia during radiofrequency ablation for paroxysmal AF, usually around the tricuspid or mitral valve; it does not affect 12-month success rates.

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