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NICE-Support programme improves frailty and quality of life in stable heart failure patientsNutrition and exercise program improves frailty in heart failure

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Key Takeaway
Consider the NICE-Support programme as a potential adjunct to improve frailty and quality of life in stable heart failure.

This randomized controlled trial enrolled 240 adults with stable heart failure at two Taiwanese medical centres. Participants had cognitive and physical capacity for activity and smartphone access. The intervention was a 12-week NICE-Support programme combining nutrition, nursing instruction, exercise, and support. The comparator was standard nursing care and routine discharge education. Follow-up occurred at 4, 12, and 24 weeks.

For the primary outcome of frailty scores, the control group demonstrated significant improvements of -8.11 points. The intervention group exhibited significantly greater improvements compared with control, with an effect size of Cohen's d = 1.17. For overall quality of life scores, the control group demonstrated significant improvements of -22.71 points. The intervention group exhibited significantly greater improvements compared with control, with an effect size of Cohen's d = 0.87.

Safety data were not reported for adverse events, serious adverse events, discontinuations, or tolerability. Key limitations include the lack of reported safety data and the specific population with smartphone access. Practice relevance suggests integration into routine care is recommended, though findings are from a single trial.

A new study shows that a comprehensive program combining nutrition counseling, exercise, and support can help older adults with heart failure become less frail and feel better overall. The research, published in a peer-reviewed journal, tested a 12-week program called NICE-Support in 240 adults aged 20 and older with stable heart failure. Participants were treated at two medical centers in Taiwan.

Half of the participants received the NICE-Support program, which included nutritional counseling, three in-person nursing consultations, a structured exercise plan, social media support, and biweekly follow-up calls. The other half received standard nursing care and routine discharge education. Researchers measured frailty and quality of life at 4, 12, and 24 weeks.

Results showed that both groups improved, but the NICE-Support group improved significantly more. Frailty scores dropped by an average of 8.11 points more in the intervention group compared to the control group, and quality of life scores improved by 22.71 points more. The effects were large, with Cohen's d values of 1.17 for frailty and 0.87 for quality of life.

No safety concerns were reported in the study. The researchers recommend integrating this program into routine care for heart failure patients. However, the study was conducted in Taiwan, so results may vary in other populations. Patients should talk to their doctor before starting any new diet or exercise program.

What this means for you:
A combined nutrition and exercise program may help reduce frailty and improve quality of life in heart failure patients.

Study Details

Study typeRct
Sample sizen = 240
EvidenceLevel 2
Follow-up2.8 mo
PublishedApr 2026
View Original Abstract ↓
AIMS: This randomized controlled trial examined the effectiveness of the 12-week NICE-Support programme-combining nutrition, nursing instruction, exercise, and support-on frailty and quality of life in patients with heart failure. METHODS AND RESULTS: A total of 240 adults (≥20 years) with stable heart failure, cognitive and physical capacity for activity, and smartphone access were recruited from two Taiwanese medical centres and randomly allocated to either the intervention group or the control group. The 12-week intervention included nutritional counselling, three in-person nursing consultations (40-60 min each), a structured exercise regimen (three 30 min sessions per week), social media support, and biweekly follow-up calls. The control group received standard nursing care and routine discharge education. Frailty and quality of life were assessed at baseline and at 4, 12, and 24 weeks to evaluate short-term and sustained effects. Among the 240 participants, 192 (80%) completed the 24-week follow-up. An intention-to-treat analysis was conducted to evaluate the intervention effects. Both groups showed significant improvements over time. At 24 weeks, the control group demonstrated significant improvements in frailty scores (-8.11 points) and overall quality of life scores (-22.71 points). Compared with the control group, the intervention group exhibited significantly greater improvements in frailty (Cohen's d = 1.17) and overall quality of life (Cohen's d = 0.87) at Week 24. CONCLUSION: The NICE-Support programme significantly reduces frailty and improves quality of life in patients with heart failure. Its integration into routine care is recommended. REGISTRATION: ClinicalTrials.gov: NCT05366686.
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