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Higher prognostic nutritional index associated with lower MACE and mortality in AF and HFpEF patientsStudy links better nutritional scores to lower heart risks in patients with two heart conditions

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Key Takeaway
Consider PNI as a potential adjunctive risk marker in AF+HFpEF, but recognize observational limitations.

This retrospective cohort study examined 734 consecutive patients with atrial fibrillation and heart failure with preserved ejection fraction (HFpEF) at a single Chinese hospital. Researchers analyzed the association between prognostic nutritional index (PNI) and clinical outcomes, comparing patients across PNI tertiles and analyzing PNI as a continuous variable.

During a median follow-up of 35 months, 131 major adverse cardiovascular events (MACE) occurred (17.8%). Higher PNI was independently associated with reduced MACE risk, with an adjusted hazard ratio (HR) of 0.904 (95% CI: 0.869–0.940) per unit increase in PNI as a continuous variable. Patients in the highest PNI tertile had a 63.4% lower MACE risk compared to the lowest tertile (HR = 0.366). For all-cause mortality, the highest PNI tertile showed an 82.6% lower risk versus the lowest tertile (HR = 0.174, P < 0.001).

Safety and tolerability data were not reported. Key limitations include the retrospective, single-center design, which prevents establishing causality. The area under the curve for PNI's discriminatory ability was 0.654, indicating limited predictive performance as a standalone marker. Funding sources and conflicts of interest were not disclosed.

In clinical practice, these findings suggest PNI may serve as an adjunctive marker for risk stratification in patients with AF and HFpEF, but its clinical utility requires prospective validation in diverse populations. The observed associations should be interpreted cautiously given the study's observational nature and methodological constraints.

Researchers looked at whether a patient's nutritional status, measured by a score called the Prognostic Nutritional Index (PNI), was connected to their risk of future heart problems. They studied 734 patients who had both atrial fibrillation (an irregular heartbeat) and a type of heart failure where the heart pumps normally but doesn't relax properly. The patients were followed for a median of 35 months at a single hospital in China.

The study found that patients with higher PNI scores had a significantly lower risk of experiencing major adverse cardiovascular events (like heart attack or stroke) and a lower risk of death from any cause. For example, patients in the top third of PNI scores had about a 63% lower risk of major heart events and an 83% lower risk of death compared to those in the bottom third.

It is important to be careful with these results. This was a retrospective study, meaning researchers looked back at existing medical records. This type of study can show a link but cannot prove that better nutrition caused the better outcomes. The study was done at one hospital, and the PNI score itself had only a modest ability to predict who would have an event. More research is needed to see if this score is useful for guiding patient care.

What this means for you:
A single study found a link between a nutritional score and heart risks, but more evidence is needed.

Study Details

Study typeCohort
EvidenceLevel 3
PublishedApr 2026
View Original Abstract ↓
To investigate the association between the prognostic nutritional index (PNI) and major adverse cardiovascular events (MACE) and all-cause mortality in patients with atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF). A total of 734 consecutive patients with AF and HFpEF were included in this retrospective cohort study, which was conducted at Yancheng First Hospital from July 2022 to July 2025. Cox proportional hazards regression models were applied to evaluate the relationship between PNI with MACE and all-cause mortality, with additional subgroup analyses performed across major clinical strata. The discriminative ability of PNI was examined using receiver operating characteristic (ROC) curve analysis, and restricted cubic spline (RCS) modeling was used to examine dose–response patterns. During a median follow-up of 35 months, 131 MACE were recorded (17.8%). In multivariable Cox regression, PNI analyzed as a continuous variable was inversely associated with MACE risk, with an adjusted hazard ratio (HR) of 0.904 (95% CI: 0.869–0.940); standardized PNI showed a similar and consistent association (HR = 0.578). Similarly, higher PNI was significantly associated with a reduced risk of all-cause mortality (P < 0.001). When assessed categorically by tertiles, patients in the highest PNI group (T3) had significantly lower risks of both MACE (HR = 0.366) and all-cause mortality (HR = 0.174) compared with the lowest tertile (P < 0.05). Similar inverse trends were observed across median, optimal cutoff, and quartile-based groupings (P < 0.05). Most subgroup analyses supported the inverse relationship between PNI and MACE (P < 0.05). ROC curve analysis showed that PNI demonstrated limited discriminatory ability for MACE with an area under the curve (AUC) of 0.654 (95% CI: 0.603–0.705). RCS analysis indicated a significant linear inverse association between PNI and MACE (P-overall < 0.001), with no evidence of non-linearity (P-nonlinear = 0.330). In patients with AF and HFpEF, higher PNI levels were independently associated with a reduced risk of MACE and all-cause mortality, indicating that PNI may serve as a potential adjunctive marker for risk stratification.
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