SGLT2 inhibitors provide robust prognostic benefits in heart failure with inconsistent results in post-myocardial infarction settings
SGLT2 inhibitors show promise for heart failure and diabetes
This narrative review examines the cardiovascular and metabolic effects of SGLT2 inhibitors, specifically empagliflozin and dapagliflozin. T…
New evidence shows how SGLT2 inhibitors may protect the heart and manage risks for patients with type 2 diabetes and heart failure.
Meta-analysis of exercise rehabilitation for HFpEF shows mixed outcomes on mortality and rehospitalization
Exercise rehab lowers rehospitalization risk for heart failure patients
This systematic review and meta-analysis of 2,025 participants with HFpEF synthesized evidence on exercise-based cardiac rehabilitation. It …
A meta-analysis of 2,025 patients found exercise-based cardiac rehabilitation significantly reduced rehospitalization risk and improved walk…
Network meta-analysis of finerenone and SGLT2 inhibitors in heart failure with preserved or mildly reduced ejection fraction
New analysis shows finerenone and SGLT2 drugs help lower heart failure hospitalization risks for patients with preserved ejection fraction
This network meta-analysis evaluated finerenone, sodium–glucose cotransporter 2 inhibitors, renin–angiotensin system inhibitors, and angiote…
A large review of over 65,000 patients found that finerenone and SGLT2 inhibitors reduce hospital stays and worsening heart failure compared…
Non-randomized preprint on dapagliflozin and epicardial adipose tissue in HFpEF
Dapagliflozin linked to fat loss in heart failure patients
This preprint reports a non-randomized clinical trial in 60 patients with left ventricular diastolic dysfunction.
Adding dapagliflozin to standard care reduced epicardial fat in a small group of heart failure patients, though this preprint study needs co…
Rule-based Clinical Decision Support System Matches Expert Assessments in Heart Failure With Preserved Ejection Fraction
AI Helps Doctors Spot Heart Failure Faster
This prospective cohort study evaluated 134 patients with exertional dyspnea and preserved left ventricular ejection fraction.
A new AI tool helps doctors diagnose stiff heart failure faster by automating complex measurements during exercise tests with high accuracy.
Combined NT-proBNP, DLK-1, PSP-D, and PCSK-9 detection shows moderate diagnostic performance for HFpEF
New blood markers may help diagnose heart failure with preserved ejection fraction more accurately
This prospective biomarker cohort study evaluated 58 HFpEF patients and 30 healthy controls to assess the diagnostic utility of specific bio…
Mixing four blood markers improves heart failure diagnosis accuracy compared to standard tests alone, offering a clearer path to early detec…
Spironolactone reduces cardiovascular events in HFpEF patients with increased LV mass or left atrial volume
Spironolactone Saves Lives in Specific Heart Failure Types
This post hoc analysis of the TOPCAT randomized controlled trial evaluated spironolactone in 757 participants with heart failure with preser…
Spironolactone cuts death risk for heart failure patients with enlarged heart chambers, proving that heart size matters just as much as pump…
HFpEF probability scores rule out disease but show limitations in AF and obesity phenotypes
HFpEF probability scores work well for typical cases but struggle with atrial fibrillation and obesity
This systematic review evaluated the performance of HFpEF probability scores (HFA-PEFF and H2FPEF) in patients with heart failure with prese…
Heart failure scores work well for typical cases but lose accuracy in patients with atrial fibrillation or obesity due to altered biological…
Network meta-analysis of pharmacotherapies shows GLP-1 RAs and SGLT2is reduce composite cardiovascular death and hospitalization in HFpEF
New drugs may lower heart failure risk and improve walking distance for patients with preserved ejection fraction
This network meta-analysis evaluated 48,235 patients with heart failure with preserved ejection fraction (HFpEF) treated with various pharma…
New heart drugs lower death risk and hospital visits for patients with preserved ejection fraction while improving walking distance.
Lipidomics analysis identifies three molecular phenogroups in HFpEF, including high-risk group
Could a simple blood test reveal which heart failure patients face the highest risk?
An observational cohort study of 177 HFpEF patients and non-HF subjects in Belgian and Canadian cohorts used plasma lipidomics to identify t…
Blood fat patterns group heart failure patients into distinct types, revealing one high-risk group with severe scarring and lower survival c…
Higher prognostic nutritional index associated with lower MACE and mortality in AF and HFpEF patients
Study links better nutritional scores to lower heart risks in patients with two heart conditions
A retrospective cohort study of 734 patients with atrial fibrillation and HFpEF found that higher prognostic nutritional index (PNI) was ind…
Patients with better nutrition scores face a 63% lower risk of heart events and an 83% lower risk of death compared to those with poorer sco…
Research across Heart Failure
Related studies from across the Heart Failure family.
Evaluating the Impact of Digital Health Interventions on Chronic Disease Self-Care Outcomes
Digital health tools show mixed results for managing chronic diseases
Digital tools show promise for heart failure monitoring but lack consistent evidence for improving medication adherence or general diabetes …
New data shows that while digital tools like apps can help heart failure patients monitor their health, they may not improve medication habi…
Aprotinin and tranexamic acid show varying efficacy for hemostasis in neonatal cardiac surgery
Trial Shows Aprotinin May Reduce Blood Loss in Infant Heart Surgery
This network meta-analysis of 27 studies involving 4,556 patients evaluated various hemostatic strategies in neonatal and infant cardiac sur…
A large review of 4,556 patients suggests aprotinin may be more effective than other treatments for managing blood loss during infant heart …
High-intensity interval aerobic exercise improves brachial FMD in coronary artery disease and heart failure
High intensity interval training improves blood flow in heart patients
This network meta-analysis of 6,818 adults with coronary artery disease or chronic heart failure found that high-intensity interval aerobic …
Specific types of intense exercise may improve blood vessel function for people living with heart failure or coronary artery disease.
Research in coronary heart disease shows misalignment between investment and clinical guideline priorities
China's heart disease research focuses on bioequivalence, not innovation
This guideline-based research trend analysis of 3,339 publications identifies a significant gap between current research investments and cli…
A review of 3,339 publications shows China's coronary heart disease research heavily emphasizes bioequivalence studies over innovative drug …
Network meta-analysis reveals resistance training offers largest LVEF gains for adult heart failure patients compared to other exercise types
Resistance training shows greatest heart function boost in network analysis
A network meta-analysis of 3,519 adult heart failure patients found resistance training yielded the greatest improvement in left ventricular…
A network meta-analysis of 3,519 heart failure patients found resistance training improved heart function more than other exercise types, wi…
Conduction system pacing improves LVEF and reduces HF hospitalization vs biventricular pacing in heart failure
Conduction system pacing shows promise for heart failure patients
This systematic review and meta-analysis of 7,019 adult HF patients (LVEF ≤ 50%) found that conduction system pacing (CSP) was associated wi…
A meta-analysis of 7,019 heart failure patients suggests conduction system pacing may improve heart function and reduce hospitalizations com…
Systematic review suggests modest risk reduction with SGLT2 inhibitors or ARNIs added to standard therapy in severe heart failure
Moderate evidence supports adding SGLT2 inhibitors to heart failure treatment
This systematic review and network meta-analysis evaluated adding SGLT2 inhibitors or angiotensin receptor-neprilysin inhibitors to neurohor…
A large analysis suggests adding SGLT2 inhibitors may lower risk of death or hospitalization for heart failure, though caution is advised.
Natriuresis-guided diuretic protocols improve fluid removal and shorten hospital stays for acute decompensated heart failure patients compared to standard care approaches in this meta-analysis review
Trial shows natriuresis-guided diuretics help heart failure patients
This systematic review and meta-analysis of 831 patients found that natriuresis-guided diuretic protocols significantly enhanced fluid remov…
A review of 831 patients finds that guiding diuretics by sodium output can increase urine output and shorten hospital stays for acute heart …
Rate of drug concentration rise alters hemodynamic responses and mortality risk in coronary heart disease patients
New analysis shows how fast drug levels change affects patient safety outcomes
This narrative review and theoretical framework synthesizes evidence on rate-dependent pharmacology. It highlights divergent hemodynamic res…
This review explains that how quickly medicine levels rise in the body matters for safety. Fast changes can cause more harm than slow ones, …
Two-lead CRT-D with atrial sensing shows noninferiority versus three-lead systems in heart failure patients
A simpler heart device works as well as the standard three-wire option for heart failure patients
A randomized trial confirms that a two-lead CRT-D capable of atrial sensing is noninferior to a standard three-lead device. Patients receivi…
A two-wire heart device matched the standard three-wire version in keeping patients alive and avoiding hospital visits over one year.
Renal denervation combined with pulmonary vein isolation increases freedom from atrial fibrillation risk in resistant hypertension patients
Renal denervation may help resistant hypertension patients with heart issues
This systematic review and meta-analysis evaluated renal denervation in patients with resistant hypertension. The pooled analysis included 8…
A meta-analysis suggests renal denervation improves heart and sleep markers in patients with resistant hypertension, though larger trials ar…
TCM and probiotics may offer a promising direction for future precision prevention and management of coronary heart disease
Traditional Chinese medicine and probiotics may help manage coronary heart disease
This narrative review discusses the potential role of traditional Chinese medicine and probiotics in coronary heart disease. The authors not…
A review suggests traditional Chinese medicine and probiotics might offer a new path for managing coronary heart disease, though more proof …
Questions about Heart Failure with Preserved Ejection Fraction
Do GLP-1 drugs and SGLT2 inhibitors reduce hospital visits for my heart failure?
Yes, both GLP-1 receptor agonists and SGLT2 inhibitors reduce hospital visits for heart failure with preserved ejection fraction (HFpEF), according to a large network meta-analysis and other studies.
Full answer →Does spironolactone lower my risk of heart problems if I have a large heart?
Yes, spironolactone may lower your risk of heart problems if you have a large heart, especially reducing heart failure hospitalizations and cardiovascular death.
Full answer →