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Baseline BMI does not significantly alter exercise capacity or lipid improvements in cardiac rehabilitation patients

Baseline BMI does not significantly alter exercise capacity or lipid improvements in cardiac…
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Key Takeaway
Note that baseline BMI does not significantly alter exercise capacity or lipid improvements in cardiac rehabilitation patients.

This systematic review and meta-analysis examined the impact of baseline body mass index on outcomes during cardiac rehabilitation programs. The analysis included eighteen studies focusing on patients recovering from cardiac events and surgeries. Researchers compared changes in exercise capacity, body composition, and lipid profiles between participants with different BMI categories, specifically contrasting obese versus non-obese and overweight versus normal weight groups.

The primary finding was that baseline obesity or overweight status did not significantly hinder improvements in exercise capacity or most lipid parameters such as total cholesterol and HDL levels. While resting heart rate and blood pressure showed no significant differences between groups, triglyceride reductions were modestly greater in patients with a normal BMI compared to those who were overweight or obese. Overall, the data suggests that initial weight status does not dictate the magnitude of physiological improvement achievable through standard rehabilitation protocols.

The authors highlight significant limitations, including high heterogeneity across the included studies and substantial variations in cardiac rehabilitation protocols. These inconsistencies prevent drawing firm conclusions about the long-term efficacy of rehabilitation across different weight categories. Consequently, the certainty of the evidence is moderate to low, and the findings should be interpreted with caution when applying them to individual patient care.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedMay 2026
View Original Abstract ↓
ObjectiveThe effectiveness of cardiac rehabilitation (CR) after cardiac events and surgeries is well known. However, whether baseline body mass index (BMI) impacts CR outcomes is unclear. This first systematic review and meta-analysis of literature examined the difference in CR outcomes based on various BMI categories.MethodsThe Web of Science, Embase, PubMed, and Scopus databases were searched until October 6, 2025, for all studies examining the outcomes of CR based on BMI. The primary outcome was the change in exercise capacity [as measured by changes in metabolic equivalents (METs)]. In contrast, secondary outcomes included changes in BMI, lipid profile, resting heart rate, and resting blood pressure.ResultsEighteen studies were included. In the comparison of obese vs. non-obese participants, pooled results showed no significant difference in the change in METs between the two groups. Subgroup analyses based on study design and obesity definition did not alter the overall findings. Among secondary outcomes, the change in BMI was not significantly different between the groups. Additionally, total cholesterol levels improved slightly more in non-obese individuals; however, there were no significant differences observed for high-density lipoprotein (HDL), triglycerides, heart rate, or blood pressure. In the comparison of overweight vs. normal BMI groups, no significant differences were observed for change in METs or BMI. Similarly, total cholesterol and HDL levels did not differ significantly between groups, although triglyceride reduction was greater among patients with a normal BMI. High heterogeneity was noted in most analyses.ConclusionsOur results indicate that pre-rehabilitation BMI does not affect improvements in exercise capacity and lipid profile in CR patients. Variations in CR protocols and high inter-study heterogeneity prohibit firm conclusions.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/view/CRD420251153489, identifier CRD420251153489.
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