This preclinical animal study investigated the effects of Danggui Sini Granule (DSG) on a rat model of vasospastic coronary heart disease. The researchers created this model using a high-fat diet, environmental stress, and pituitrin injection. They then treated the rats with DSG at different doses to observe changes in heart and body markers.
The study found that DSG treatment was associated with reduced ST-segment elevation and less injury to heart tissue. It also appeared to lower systemic inflammatory markers like TNF-α and IL-6. Additionally, the treatment mitigated dyslipidemia and altered gut microbial populations by reducing harmful bacteria while enriching beneficial ones.
These findings come from a review of preclinical data and in silico molecular docking. The authors note that the multi-omics data are associative rather than proving direct cause and effect. Key causal links need validation in future targeted intervention studies before these results can be applied to human patients.