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Oral antioxidants improve clinical pregnancy and live birth rates in IVF patientsAntioxidants may improve pregnancy success for women undergoing IVF

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Key Takeaway
Consider oral antioxidants as a potential adjuvant in IVF, but await larger trials to confirm benefits.

This meta-analysis evaluated the effect of oral antioxidant supplementation in women undergoing in vitro fertilization or intracytoplasmic sperm injection with embryo transfer. The primary outcome was clinical pregnancy rate, with secondary outcomes including number of mature oocytes, high-quality embryos, live birth rate, and miscarriage rates.

The analysis found that antioxidant supplementation was associated with improvements in clinical pregnancy rate, number of mature oocytes, number of high-quality embryos, and live birth rate. The authors noted that these findings suggest potential clinical benefits, particularly in patients using an antagonist protocol.

Key limitations include a limited number of included studies and methodological heterogeneity among trials. The authors call for further large-scale randomized controlled trials to strengthen the evidence, especially for outcomes such as high-quality embryos, live birth rates, and miscarriage rates.

Clinicians should consider these findings cautiously. While antioxidants may offer benefits as an adjuvant therapy, the current evidence base is insufficient to recommend routine use. Further research is needed to confirm these results and identify which patients are most likely to benefit.

For many women, the road to parenthood through IVF is filled with hope and uncertainty. New data suggests that adding oral antioxidants to a treatment plan might provide some extra support. This analysis looked at how these supplements affect various stages of the process, from egg quality to final birth rates.

The findings show that women taking antioxidants saw improvements in several key areas. These included a higher number of mature eggs, more high-quality embryos, and an increased rate of clinical pregnancies. The data also showed an improvement in live birth rates for those undergoing specific IVF protocols.

While these results are encouraging, it is important to note that the evidence comes from a small number of studies with different methods. Because of this limited amount of data, experts say more large-scale trials are needed to fully confirm how much of an impact antioxidants have on embryo quality and birth rates.

What this means for you:
Antioxidants may improve egg quality and pregnancy rates for women undergoing IVF treatments.

Common questions

Can antioxidants help with my IVF treatment?

The data suggests that oral antioxidant supplements can lead to a significant improvement in clinical pregnancy rates. They were also linked to an increase in the number of mature eggs and high-quality embryos for women undergoing IVF.

Does taking antioxidants improve birth rates?

The analysis showed an improvement in live birth rates for women using these supplements during their treatment. However, because the study included a limited number of reports, more large-scale trials are needed to confirm these specific results.

Is this finding certain enough to change my treatment?

The findings show potential benefits for pregnancy rates and egg quality. However, because the study had a limited number of included studies and some differences in methods, you should talk to your doctor about how these results apply to your specific case.

Study Details

Study typeMeta analysis
EvidenceLevel 1
PublishedJul 2026
View Original Abstract ↓
BackgroundThe clinical efficacy of antioxidants in assisted reproductive technology (ART) remains inconsistent. This systematic review and meta-analysis aimed to evaluate the impact of oral antioxidant supplementation on reproductive outcomes in patients undergoing in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET).MethodsWe systematically searched PubMed, Scopus, Embase, and Web of Science databases from inception to February 2026 for randomized controlled trials (RCTs) investigating oral antioxidants in patients undergoing ART. We performed meta-analyses by pooling effect sizes, conducting subgroup analyses, and exploring heterogeneity. Methodological quality was assessed using the Risk of Bias (RoB) tool, and the certainty of evidence was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework. Sensitivity analyses and publication bias assessments were also conducted.ResultsThis meta-analysis suggests that oral antioxidant supplementation may provide potential clinical benefits for women undergoing IVF/ICSI-ET. The pooled estimates indicated a significant improvement in the clinical pregnancy rate (RR = 1.29, 95% CI: 1.070–1.554), the number of morphologically mature oocytes (MII oocytes) (MD = 2.99, 95% CI: 1.82–4.16), the number of high-quality embryos (MD = 1.08, 95%CI: 0.69–1.47), and the live birth rate (RR = 1.407, 95% CI: 1.052–1.881). Due to the limited number of included studies, further large-scale RCTs are required to confirm these findings regarding high-quality embryos, live birth rates, and miscarriage rates, thereby strengthening the overall level of evidence.ConclusionOral antioxidant supplementation as an adjuvant therapy shows potential clinical benefits in improving clinical pregnancy rates, MII oocyte yields, the number of high-quality embryos, and live birth rates in women undergoing IVF/ICSI-ET. Notably, antioxidants appear to offer broader clinical utility in patients undergoing the antagonist protocol. Given the current limitations in study volume and methodological heterogeneity, future well-designed RCTs—stratified by patient characteristics and employing standardized antioxidant regimens—are warranted. In particular, studies prioritizing live birth as the primary endpoint are essential to establish definitive clinical recommendations.Systematic review registrationidentifier CRD420251238213.
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