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CHG index associated with increased diabetes risk in Chinese adults in retrospective cohort studyStudy finds link between cholesterol-glucose index and diabetes risk in Chinese adults

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Key Takeaway
Consider CHG index as a potential diabetes risk marker, but recognize findings are from an observational study.

A retrospective cohort study followed 8,844 Chinese adults who underwent comprehensive health examinations at Shenzhen Kuichong People’s Hospital for a median of 2.72 years (IQR 2.58–4.78 years), with maximum follow-up reaching 5 years. The study examined the association between the Total Cholesterol–High-Density Lipoprotein–Glucose (CHG) index and incident diabetes mellitus. No specific comparator was reported.

The main finding was that the CHG index was independently associated with increased diabetes risk, with a hazard ratio of 1.150 per 0.1 unit increase in the CHG index (95% CI: 1.098–1.204). For predictive capability, the CHG index had the highest area under the curve for predicting diabetes risk, with an AUC of 0.7377. Absolute numbers for diabetes incidence were not reported.

Safety and tolerability data were not reported. Key limitations were not explicitly listed in the provided evidence. The study design was observational, meaning the findings demonstrate association rather than causation. The practice relevance is that this research may help clinicians identify high-risk individuals for diabetes early, though clinical application requires validation in prospective studies.

Researchers looked at whether a combined measure of cholesterol and blood sugar, called the CHG index, could help predict who might develop diabetes. They studied 8,844 Chinese adults who had regular health check-ups at one hospital, following them for up to 5 years. The study found that people with higher CHG index scores were more likely to be diagnosed with diabetes during the follow-up period.

The analysis showed that for every 0.1 unit increase in the CHG index, the risk of developing diabetes increased by about 15%. The index appeared to be a better predictor of diabetes risk than looking at cholesterol or glucose levels alone. No safety concerns were reported because this study simply observed people's health data rather than testing a treatment.

It's important to understand that this was a retrospective observational study, which means researchers looked back at existing health records. This type of study can show associations but cannot prove that the CHG index causes diabetes. The study was also conducted at a single hospital in China, so the findings might not apply to everyone.

Readers should know that this research suggests a simple blood test combination might help identify people at higher risk for diabetes earlier. However, more research is needed to confirm these findings and understand how this information could be used in routine healthcare.

What this means for you:
A cholesterol-glucose index was linked to diabetes risk in one study, but more research is needed to confirm this finding.

Study Details

Study typeCohort
EvidenceLevel 3
PublishedApr 2026
View Original Abstract ↓
ObjectiveResearch on the relationship between Total Cholesterol, High-Density Lipoprotein, and Glucose (CHG) index and diabetes mellitus (DM) risk remains limited. This study aims to investigate the association between CHG and DM incidence.MethodsThis retrospective cohort study included 8,844 participants who underwent comprehensive health examinations at Shenzhen Kuichong People’s Hospital between 2018 and 2023. The maximum individual follow-up duration reached 5 years, with a median (interquartile range) follow-up period of 2.72 (2.58–4.78) years. Cox proportional hazards regression models were used to evaluate the association between CHG and DM risk. ROC analysis was conducted to evaluate the predictive capability of CHG for DM. Finally, subgroup analyses and sensitivity analyses were performed to further verify the stability of these findings.ResultsAfter multivariate adjustment, the CHG index was independently associated with increased DM risk, with an HR of 1.150 (95% CI: 1.098–1.204) per 0.1 unit increase in CHG. Furthermore, ROC curve analysis demonstrated that CHG had the highest AUC (0.7377) for predicting DM risk, compared to TC (0.5375), HDL-c (0.6105), and FPG (0.6761). The stability of these results was further validated through sensitivity and subgroup analyses.ConclusionThis study found an independent positive relationship between CHG and DM risk. Additionally, CHG demonstrates a certain predictive value for DM risk. This helps clinicians identify high-risk individuals for DM early and provides a new perspective for optimizing clinical prevention and management of DM.
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