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Comparative Efficacy and Safety of Endoscopic Sleeve Gastroplasty Versus Laparoscopic Sleeve GastrectomySleeve gastrectomy leads to more weight loss than endoscopic procedure

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Key Takeaway
LSG provides superior weight loss, while ESG offers a significantly lower risk of adverse events and de novo GERD.

This meta-analysis evaluates the clinical outcomes of endoscopic sleeve gastroplasty (ESG) compared to the traditional laparoscopic sleeve gastrectomy (LSG) in patients undergoing bariatric procedures. By analyzing a large cohort of 7,442 patients, the study provides a comparative framework for clinicians deciding between endoscopic and surgical interventions for weight management and gastroesophageal reflux disease (GERD) management.

Regarding primary outcomes, the data indicates that LSG achieves superior weight loss results compared to ESG. At the 6-month mark, ESG was associated with lower total body weight loss (TBWL%) than LSG. This trend continued at 12 months, where the difference in weight loss remained statistically significant. By 24 months, the data confirmed that LSG patients achieved higher weight loss percentages than their counterparts who underwent the endoscopic procedure.

While LSG provides superior weight reduction, the safety profile of ESG presents a distinct clinical advantage. The meta-analysis found that ESG was associated with a significantly lower risk of overall adverse events compared to LSG (RR 0.54, p=0.03). This suggests that the endoscopic approach may offer a more tolerable experience for patients who are at higher risk for surgical complications or who prefer less invasive techniques.

Furthermore, the study highlights a critical distinction in the management of gastroesophageal reflux. Patients undergoing ESG demonstrated a significantly lower risk of developing de novo GERD compared to those undergoing LSG (RR 0.33, p=0.02). This finding is particularly relevant for patients with pre-existing reflux issues who may be concerned about the potential for surgical complications affecting esophageal health. Clinicians must weigh the trade-off between the superior weight loss efficacy of LSG and the enhanced safety profile and lower GERD incidence of ESG. While LSG remains the gold standard for maximum weight reduction, ESG emerges as a viable alternative for specific patient populations. These patients may include those who prioritize the avoidance of surgical risks or those with significant concerns regarding reflux complications.

Limitations of the study include a lack of extensive long-term comparative data beyond the two-year mark. However, the current evidence provides a robust foundation for evidence-based decision-making. The choice between these two procedures should be tailored to individual patient goals, specifically balancing the desire for maximum weight loss against the preference for a lower risk of adverse events and reflux-related complications.

For people struggling with severe weight issues, choosing the right surgical path is a major decision. Some patients face a difficult choice between traditional surgery and newer, less invasive procedures. This choice often comes down to a balance between how much weight they can lose and how much risk they are willing to take. This is especially true for people who also suffer from GERD, which is a condition where stomach acid flows back into the throat, causing irritation.

To understand these options better, researchers looked at data from over 7,000 patients. They compared two different methods: laparoscopic sleeve gastrectomy (LSG) and endoscopic sleeve gastrectomy (ESG). LSG is a traditional surgery where a surgeon removes a large portion of the stomach. ESG is a newer, less invasive method performed through an endoscope, which is a tube passed through the mouth. The study tracked these patients for about 32 months to see how they fared in terms of weight loss and safety.

The results showed a clear difference in weight loss. Patients who had the traditional surgery (LSG) lost significantly more weight than those who had the endoscopic procedure (ESG). This difference was consistent at the 6-month, 12-month, and 24-month marks. While the endoscopic procedure was effective, it did not result in the same amount of weight loss as the surgical option over the first two years.

However, the endoscopic procedure did have some advantages regarding safety. Patients who chose the ESG procedure had a lower risk of experiencing overall complications. Most importantly, they had a much lower risk of developing new cases of GERD after their procedure. This makes the endoscopic option a potential path for people who are worried about surgical risks or who already have acid reflux issues.

It is important to remember that this is a meta-analysis, which means it combines data from many different studies to find a general trend. Because of this, we should not view these results as a final rule for every individual. There is still limited data on how these two procedures compare over the very long term.

For patients today, this means that both procedures are viable options, but they offer different trade-offs. If the primary goal is the maximum amount of weight loss possible, the traditional surgery shows stronger results. If a patient is concerned about surgical complications or has a history of acid reflux, the endoscopic procedure may be a safer alternative. Patients should talk to their doctors to decide which path fits their specific health goals.

What this means for you:
Traditional surgery leads to more weight loss, while the endoscopic option has fewer complications and less reflux.

Study Details

Study typeMeta analysis
Sample sizen = 7,442
EvidenceLevel 1
PublishedOct 2026
View Original Abstract ↓
INTRODUCTION: Laparoscopic sleeve gastrectomy (LSG) is the most common bariatric operation worldwide, with the endoscopic sleeve gastroplasty (ESG) emerging as a non-surgical bariatric procedure with comparable outcomes to LSG. Long-term comparative data of ESG to LSG are limited but increasing. The purpose of this study was to compare the long-term efficacy and adverse outcomes including rates of de novo gastro-esophageal reflux disease (GERD). METHODS: A systematic review and meta-analysis were performed comparing outcomes of ESG versus LSG using a random effects model with restricted maximum likelihood. A comprehensive search of Ovid MEDLINE, Ovid Embase, Scopus, Web of Science Core Collection, and Cochrane Library (via Wiley) was performed. Studies comparing outcomes and adverse events following primary ESG or LSG with a sample size > 5 were included. RESULTS: Of 1136 unique results, 10 studies were included, comprising 7442 patients, of whom 3583 (48%) underwent ESG and 3859 (52%) underwent LSG. Mean age was 35.5 years and mean initial BMI was 34.6 kg/m. Most patients were female (86.2%) and mean follow-up was 32.1 months. Meta-analysis revealed ESG was associated with lower total body weight loss (TBWL%) at 6 months (9 studies, mean diff. -8.34%, 95%CI, -10.50 to -6.19), 12 months (6 studies, mean diff. - 12.58%, 95%CI -15.47 to - 9.70) and 24 months (3 studies, mean diff. -9.81%, 95%CI -14.72 to -4.90). ESG was associated with a lower risk of both overall adverse events (9 studies, RR 0.54, p = 0.03) and de novo (GERD) (5 studies, RR 0.33, p = 0.02). CONCLUSIONS: The results of this review suggest that while LSG achieves greater weight loss up to two years postoperatively, ESG still displays moderate weight loss with a significantly lower risk of both adverse events and de novo GERD, making it a potential option for patients wishing to avoid greater surgical risks or with pre-existing GERD.
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