Multidisciplinary management in T2DM patients yielded a 29.24% remission rate in a single-arm observational study.

ObjectiveTo evaluate the effects of multidisciplinary management in the Diabetes Reversal Clinic on the remission of type 2 diabetes mellitus (T2DM), and explore the predictive factors for remission of diabetes.MethodsThis was a real-world, single-arm observational study. Patients with T2DM who received remission-oriented treatment at the Diabetes Reversal Clinic and followed up regularly for more than 24 weeks were included. The primary outcome was the remission rate of T2DM, and the secondary outcomes were changes in fasting blood glucose (FBG), 2-hour postprandial blood glucose, HbA1c, blood lipids, and body composition. Differences in clinical characteristics between the remission and non-remission groups were analyzed. The multivariate logistic regression analysis was performed to screen predictive factors.ResultsThe remission rate was 29.24% (50/171) after multidisciplinary management in the Diabetes Reversal Clinic. The remission group was younger, had a shorter duration of diabetes, used fewer types of medications at baseline, had a lower FBG and HbA1c, a higher β-cell function index HOMA-β, and a lower triglyceride level. The multivariate logistic regression analysis revealed that age (OR = 0.93, 95% CI: 0.89-0.97, P = 0.002), type of medications at baseline (OR = 0.45, 95% CI: 0.26-0.77, P = 0.004), baseline FBG (OR = 0.64, 95% CI: 0.46-0.89, P = 0.008), and weight loss magnitude (OR = 1.15, 95% CI: 1.01-1.31, P = 0.038) were independent predictors of T2DM remission.ConclusionIn this real-world study, the remission rate of T2DM patients who visited the Diabetes Reversal Clinic for more than 24 weeks was 29.24% (50/171). Younger age, shorter disease duration, fewer baseline medications, lower FBG and HbA1c, higher HOMA-β, lower triglycerides, and greater weight loss were associated with remission of T2DM. Among them, age, baseline medication type, baseline FBG, and weight loss were identified as factors independently associated with remission. However, due to the single-arm observational design, causality cannot be established, and further prospective controlled trials are required to confirm these findings.