Thyroid dysfunction and atrial fibrillation risk in hypertrophic obstructive cardiomyopathy patients

This retrospective observational cohort study analyzed 755 patients with hypertrophic obstructive cardiomyopathy (HOCM) from three tertiary centers between 2019 and 2024. The study categorized thyroid dysfunction by thyroid-stimulating hormone (TSH) levels and examined its association with the risk of atrial fibrillation (AF), using patients with normal TSH levels as an implied comparator.

The main result stated that the association between thyroid dysfunction and AF risk in HOCM remains poorly defined. No specific effect size, absolute numbers, p-values, or confidence intervals were reported in the provided abstract. The follow-up duration was not reported.

Safety and tolerability data were not reported, including adverse events, serious adverse events, or treatment discontinuations. Key limitations include the retrospective design and that it was not reported if a full analysis was completed or if results were available.

This is an observational study and reports an association, not causation. Given the lack of reported data, certainty is low. Practice relevance was not reported, and no clinical recommendations can be derived from these findings.