Higher ZJU index associated with worse metabolic profiles in adults with type 2 diabetes and hyperuricemia

This retrospective cross-sectional analysis included 1772 adults with type 2 diabetes mellitus from the Affiliated Hospital of Jiangsu University. The study population was classified by hyperuricemia status to evaluate the association between the Zhejiang University (ZJU) index and metabolic health.

The primary outcome assessed the association between ZJU index levels and hyperuricemia. Results indicated that higher ZJU index levels were significantly associated with worse metabolic profiles in patients with hyperuricemia. Secondary outcomes included broader metabolic profiles, which also reflected this association.

Safety data, adverse events, and serious adverse events were not reported in the provided evidence. The study design is a retrospective cross-sectional analysis, which limits the ability to infer causality. Key limitations regarding follow-up duration and specific adverse event rates were not reported. Consequently, the practice relevance remains uncertain, and clinicians should interpret these findings as observational associations rather than definitive clinical guidance.