Systematic review synthesizes Rhaponticum species chemistry, traditional uses, and research gaps across multiple conditions.

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Frontiers in Medicine Published April 24, 2026 Medically reviewed April 24, 2026 DOI ↗ By Dr. Julia Lee, PhD · Oncology, Genomics & Drug Development

Key Takeaway

Note that Rhaponticum research focuses on Asian species, leaving efficacy and safety unclear for many conditions.

This systematic review evaluates the phytochemical metabolites, traditional uses, and pharmacological activities of Rhaponticum species. The scope encompasses 24 documented species worldwide, addressing a broad range of conditions such as rheumatoid arthritis, neurasthenia, kidney deficiency, lumbago, gastrointestinal disorders, hypertension, hyperlipidemia, tumor, inflammation, liver disease, heart disease, and influenza. The authors report that 217 metabolites have been isolated and identified, falling into classes including steroids, flavonoids, sesquiterpenoids, thiophenes, triterpenoids, and others. Additionally, the review highlights a centuries-old history of folk medicinal use for these plants.

The authors note that research has predominantly focused on a limited number of Asian species. Consequently, the material basis, mechanism of action, and therapeutic efficacy of many species remain unclear. The review explicitly states that systematic studies on the bioactive metabolites, pharmacological effects, and toxicological profiles of understudied species are insufficient. No adverse events, serious adverse events, discontinuations, or tolerability data were reported in this synthesis.

The review provides a valuable reference for the further development and rational utilization of Rhaponticum. However, the authors emphasize that current knowledge is limited by the lack of comprehensive data on understudied species. Practice relevance is framed cautiously, as the evidence does not yet support definitive clinical recommendations for specific indications due to the insufficient systematic studies on toxicological profiles and pharmacological effects.

Study Details

Study typeMeta analysis

EvidenceLevel 1

PublishedApr 2026

View Original Abstract ↓

BackgroundThe genus Rhaponticum (Asteraceae/Compositae) comprises 24 species worldwide and has long been utilized in traditional medicine for clearing heat, detoxification, relieving intestinal colic, and treating rheumatoid arthritis, neurasthenia, kidney deficiency, lumbago, and gastrointestinal disorders. Modern pharmacological studies have revealed its diverse bioactivities, including antihypertensive, hypolipidemic, immunomodulatory, neuroprotective, antitumor, hepatoprotective, cardioprotective, anti-inflammatory and anti-influenza effects. However, a comprehensive systematic review integrating its traditional uses, phytochemical metabolites and pharmacological activities is still lacking, which hinders its further development and rational utilization.PurposeThis study aims to fill the existing research gap by systematically collating and summarizing the traditional medicinal applications, phytochemical compositions, and proven pharmacological activities of Rhaponticum species, thereby laying a solid theoretical foundation for the subsequent development, utilization, and in-depth research of this genus.ObjectiveThis review aims to systematically summarize the traditional applications, phytochemical profiles, and pharmacological activities of Rhaponticum species, provide a theoretical basis for their future development and utilization, and highlight the necessity of further investigations into this valuable genus.MethodsThis study was primarily conducted through comprehensive literature search and screening. The retrieval sources included ethnobotanical textbooks, peer-reviewed journals, and scientific databases such as PubMed, Web of Science, Scifinder, and Google Scholar. The search terms encompassed the genus Rhaponticum, its representative species (e.g., Rhaponticum uniflorum, Rhaponticum carthamoides). Literature screening was based solely on relevance to the focus of the review, with the past 4 decades.ResultsRhaponticum species have a centuries-old history of folk medicinal use, with different ethnic groups utilizing various medicinal parts to treat diverse diseases. A total of 217 metabolites have been isolated and identified from Rhaponticum, covering steroids, flavonoids, sesquiterpenoids, thiophenes, triterpenoids, and other classes. Consistent with traditional uses, modern pharmacological studies have confirmed their antihypertensive, hypolipidemic, antitumor, neuroprotective, anti-inflammatory, cardioprotective, hepatoprotective, antimicrobial, and anti-influenza activities.ConclusionDespite 24 documented Rhaponticum species, research has predominantly focused on a limited number of Asian species. The material basis, mechanism of action, and therapeutic efficacy of many species remain unclear, and systematic studies on the bioactive metabolites, pharmacological effects, and toxicological profiles of understudied species are insufficient. Given its traditional medicinal value and proven pharmacological activities, further investigations into understudied species, clarification of the molecular mechanisms of core bioactivities, and supplementation of toxicological data are warranted. This review systematically collates the traditional applications, phytochemical compositions, and modern pharmacological value of Rhaponticum, providing a valuable reference for its further development and rational utilization.