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Home › Conditions › Influenza

Influenza

Part of Orthomyxoviridae Infections

Subtypes of Influenza

Influenza A(H3N2) 5 Highly Pathogenic Avian Influenza A(H5N1) Virus Infection 1 Influenza-Associated Encephalitis 1 Influenza-Associated Encephalopathy 1 Invasive pulmonary aspergillosis following influenza 1 Avian Influenza A(H5) Infection 0 Influenza B/Victoria Virus Infection 0

61 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Influenza

437 trials tracked for Influenza: 234 in phase 3 or 4 and 60 with published results. The most-cited published study has 919 citations.

437Trials tracked
234Phase 3 & 4
0Recruiting
60With published results
Phase distribution
Phase 4 100 Phase 3 134 Phase 2 127 Phase 1 30 Other / NA 46
  1. Phase 3 A Study of S-033188 (Baloxavir Marboxil) Compared With Placebo or Oseltamivir in Otherwise Healthy Patients With Influenza Completed · 919 cited
  2. Phase 4 T-cell And General Immune Response to Seasonal Influenza Vaccine (SLVP018) Year 3, 2011 Completed · 333 cited
  3. Phase 4 T-cell And General Immune Response to Seasonal Influenza Vaccine (SLVP018) - Year 1, 2009 Completed · 333 cited
  4. Phase 4 T-cell And General Immune Response to Seasonal Influenza Vaccine (SLVP018) Year 2, 2010 Completed · 333 cited
  5. Phase 3 Protective Efficacy of Flublok® Quadrivalent Versus Licensed Inactivated Influenza Vaccine in Adults ≥50 Years of Age Completed · 284 cited
  6. Phase 4 Control of Epidemic Influenza Through a School-based Influenza Vaccination Program Completed · 276 cited
Show 44 more trials
  1. Phase 3 Study of S-033188 (Baloxavir Marboxil) Compared With Placebo or Oseltamivir in Patients With Influenza at High Risk of Influenza Complications Completed · 259 cited
  2. Phase 3 Efficacy, Safety, and Immunogenicity of a Plant-Derived Quadrivalent Virus-Like Particles (VLPs) Influenza Vaccine in Adults Completed · 192 cited
  3. Phase 3 Immunogenicity, Safety, Reactogenicity, Efficacy, Effectiveness and Lot Consistency of FluBlok Completed · 161 cited
  4. Phase 4 Comparison of Immune Responses to Influenza Vaccine In Adults of Different Ages (SLVP015 2007-2017) Completed · 151 cited
  5. Phase 4 Pilot Study in Young Adults to Examine the Kinetics of Changes in the B-cell Repertoire Following TIV Immunization Completed · 142 cited
  6. Phase 3 Safety and Efficacy of H1N1 Vaccines in Children Aged 6 Months to Less Than 10 Years of Age Completed · 141 cited
  7. Phase 3 Study to Assess Efficacy and Safety of Baloxavir Marboxil In Combination With Standard-of-Care Neuraminidase Inhibitor In Hospitalized Participants With Severe Influenza Completed · 135 cited
  8. Phase 3 Study to Assess the Safety, Pharmacokinetics, and Efficacy of Baloxavir Marboxil in Healthy Pediatric Participants With Influenza-Like Symptoms Completed · 115 cited
  9. Phase 3 Efficacy Study of an Investigational Influenza Vaccine (Vero Cell Derived) to Prevent Culture Confirmed Influenza Infection (CCII) Completed · 100 cited
  10. Phase 3 Study to Evaluate the Safety and Immunogenicity of a Pandemic Influenza Vaccine in Adults Aged 18 Years and Above Completed · 94 cited
  11. Phase 3 Study to Evaluate Immunogenicity and Safety of an Investigational Influenza Vaccine (H1N1) in Adults Completed · 85 cited
  12. Phase 3 Safety and Immunogenicity of High-Dose Quadrivalent Influenza Vaccine in Participants ≥65 Years in the US Completed · 75 cited
  13. Phase 3 Lot-to-lot Consistency of a Plant-Derived Quadrivalent Virus-Like Particles Influenza Vaccine in Healthy Adults Completed · 72 cited
  14. Phase 3 Clinical Study to Evaluate the Safety, Immunogenicity and Efficacy of Investigational Flu Vaccine Compared to Approved Flu Vaccine in Children. Completed · 67 cited
  15. Phase 4 B-cell Immunity to Influenza (SLVP017) - Years 2 (2010) & 3 (2011) Completed · 56 cited
  16. Phase 4 B-cell Immunity to Influenza (SLVP017)- Year 1, 2009 Completed · 56 cited
  17. Phase 3 Safety and Immunogenicity of Flublok Quadrivalent vs IIV4 in Adults 18-49 Years of Age Completed · 56 cited
  18. Phase 4 Effect of Age and Prior Immunity to Response to Seasonal Influenza Vaccines in Children Completed · 51 cited
  19. Phase 4 Comparison of Three Licensed Influenza Vaccines Completed · 51 cited
  20. Phase 3 Clinical Study to Evaluate the Efficacy, Safety and Immunogenicity of an MF59-Adjuvanted Quadrivalent Influenza Vaccine Compared to Non-influenza Vaccine Comparator in Adults ≥ 65 Years of Age Completed · 48 cited
  21. Phase 4 Randomized Trial of High Dose Influenza Vaccine in Long Term Care Setting Completed · 45 cited
  22. Phase 4 Immunogenicity Trial of Egg- Versus Non-Egg-Based Influenza Vaccines Among HCP Completed · 45 cited
  23. Phase 4 Rapid Empiric Treatment With Oseltamivir Study (RETOS) Completed · 44 cited
  24. Phase 3 An Efficacy Study of GlaxoSmithKline (GSK) Biologicals' Candidate Influenza Vaccine GSK2321138A in Children Completed · 43 cited
  25. Phase 3 Safety, Immunogenicity, and Relative Efficacy of H1N1 Vaccines in Adults Aged 18 Years and Older Completed · 39 cited
  26. Phase 3 A Study of mRNA-1083 (SARS-CoV-2 and Influenza) Vaccine in Healthy Adult Participants, ≥50 Years of Age Completed · 37 cited
  27. Phase 3 Study to Evaluate the Immunogenicity and Safety of an Investigational Influenza Vaccine (H1N1) in Children Completed · 34 cited
  28. Phase 3 Safety and Immunogenicity Study of GSK Biologicals' Pandemic Influenza Candidate Vaccine (H1N1) (GSK2340272A) Completed · 34 cited
  29. Phase 3 Evaluation of the Immunogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' Quadrivalent Influenza Vaccine Influsplit™ Tetra (Fluarix™ Tetra) (GSK2321138A) When Co-administered With Pneumovax™ 23 in Adults 50 Years of Age and Older Completed · 32 cited
  30. Phase 3 Immunogenicity and Safety Study of an Inactivated Influenza Vaccine (Split Virus, Vero Cell Derived) in Adults Aged 50 Years and Older Completed · 30 cited
  31. Phase 4 Safety and Immunogenicity of Fluzone® Quadrivalent Vaccine Administered to Healthy Children Completed · 29 cited
  32. Phase 3 Study to Assess the Efficacy of Baloxavir Marboxil Versus Placebo to Reduce Onward Transmission of Influenza A or B in Households Completed · 28 cited
  33. Phase 3 Assess Consistency of Immunogenicity of GlaxoSmithKline Biologicals' Pandemic Influenza Vaccine (GSK1562902A) in Adults Completed · 23 cited
  34. Phase 3 Immunogenicity of GSK Biologicals' Pandemic Influenza Vaccine (GSK1562902A) at Different Boosting Vaccination Schedules Completed · 23 cited
  35. Phase 4 Self-Administered Nasal Influenza Feasibility Study Completed · 22 cited
  36. Phase 4 The Immunogenicity of Simultaneous Administration of Quadrivalent Influenza Vaccine and 23-valent Pneumococcal Vaccine Completed · 20 cited
  37. Phase 3 Study to Evaluate the Immunogenicity & Safety of an Investigational Influenza Vaccine (H1N1) in Adults Completed · 18 cited
  38. Phase 3 Immunogenicity and Safety Study of an Investigational Influenza (H1N1 Influenza Virus) Vaccine in Adults Completed · 18 cited
  39. Phase 4 Safety of LAIV4 in Children With Asthma Completed · 17 cited
  40. Phase 3 Immunogenicity and Safety of a Quadrivalent Influenza Vaccine Given by Intramuscular Route in Subjects Aged 18 to 60 Years Completed · 15 cited
  41. Phase 3 Safety and Immunogenicity Study of QIVc in Healthy Pediatric Subjects Completed · 15 cited
  42. Phase 3 Safety, Reactogenicity and Immunogenicity of Flublok Quadrivalent (Recombinant Influenza Vaccine,Seasonal Formulation) Completed · 14 cited
  43. Phase 4 Study of GSK Biologicals' Influenza Vaccine Arepanrix™ in Japanese Adults 65 Years of Age or Older Completed · 12 cited
  44. Phase 3 Study to Evaluate Immunological Equivalence Between Two Investigational Influenza Vaccines in Adults (H1N1) Completed · 11 cited

Showing the 50 most-cited and recently-updated of 437 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
High-dose quadrivalent influenza vaccine shows non-inferior immunogenicity in Chinese children aged 6 to 35 months
Pediatrics RCT
High-dose quadrivalent influenza vaccine shows non-inferior immunogenicity in Chinese children aged 6 to 35 months High-dose flu shots show greater protection for young children in China
This randomized, double-blind study in 3,000 Chinese children aged 6 to 35 months found an investigational high-dose quadrivalent influenza …
A new study in China shows high-dose flu vaccines work as well as or better than standard shots for toddlers, offering stronger protection a…
May 28, 2026
Review of influenza A and secondary bacterial infections identifies critical knowledge gaps
Infectious Disease Sys. Review
Review of influenza A and secondary bacterial infections identifies critical knowledge gaps Review highlights gaps in flu and secondary infection care
This is a narrative review on influenza A virus infection, secondary bacterial infection, and nosocomial infection. The authors synthesize c…
A new review points out major missing knowledge about flu and related infections. It calls for more research to help patients.
Frontiers May 25, 2026
Systematic review compares viral and bacterial pathogen mechanisms in respiratory infections
Infectious Disease Sys. Review
Systematic review compares viral and bacterial pathogen mechanisms in respiratory infections Understanding how different germs hurt lungs helps doctors treat patients better and faster today
This systematic review synthesizes evidence regarding receptor recognition, cellular injury, and immunopathological mechanisms across SARS-C…
This review explains how three common germs damage human cells in unique ways. Knowing these differences helps doctors predict sickness and …
Frontiers May 13, 2026
mRNA-1010 shows superior efficacy against influenza in older adults
Drug Pipeline RCT
mRNA-1010 shows superior efficacy against influenza in older adults New flu shot cuts illness by 27 percent in adults over 50
A phase 3 trial found mRNA-1010 vaccine had 26.6% relative efficacy versus standard comparator in adults 50+.
A new mRNA flu vaccine reduced confirmed flu illness by 27 percent compared with the standard shot in adults 50 and older.
May 7, 2026
Six H5N1 vaccine formulations showed immunogenicity and acceptable safety in 420 healthy children aged 6 months to 9 years
Pediatrics RCT
Six H5N1 vaccine formulations showed immunogenicity and acceptable safety in 420 healthy children aged 6 months to 9 years Higher adjuvant content boosts immunity in children without added safety risks
This phase 2, observer-blind, multicenter study evaluated six formulations of MF59-adjuvanted H5N1 vaccine in 420 healthy infants and childr…
A Phase 2 trial in healthy children found that higher adjuvant content improved immune responses to an H5N1 vaccine without increasing side …
Apr 30, 2026
Systematic review and meta-analysis finds bacterial co-infection in 17.3% of hospitalized influenza patients
Infectious Disease
Systematic review and meta-analysis finds bacterial co-infection in 17.3% of hospitalized influenza patients Hospital data shows high rates of bacterial co-infection in influenza patients
This systematic review and meta-analysis of 111,889 hospital-attended patients with laboratory-confirmed influenza found a pooled prevalence…
Analysis of over 111,000 patients reveals that bacterial co-infection occurs in 17.3% of hospital cases with confirmed influenza infection.
medRxiv Apr 30, 2026
Coadministration of RSV mRNA vaccine and high-dose flu vaccine noninferior for flu but not for RSV in older adults
Drug Pipeline RCT
Coadministration of RSV mRNA vaccine and high-dose flu vaccine noninferior for flu but not for RSV in older adults New data shows RSV and flu shots work well together
This phase 3 randomized controlled trial in 1900 adults aged 65 and older compared coadministration of mRNA-1345 and quadrivalent influenza …
Older adults can now get their RSV and flu vaccines during one visit without safety risks or extra trips to the clinic for care.
Apr 29, 2026
Survey finds physicians show stronger intergroup bias than public on vaccines
Infectious Disease
Survey finds physicians show stronger intergroup bias than public on vaccines Doctors Show Strong Bias Against Vaccine-Hesitant Patients
This review of an online survey in Japan involving 492 physicians and 5,252 members of the general public found that physicians exhibited hi…
Doctors often see themselves as targets of vaccine anger, but new data shows they also hold strong bias against patients who question vaccin…
medRxiv Apr 26, 2026
Systematic review synthesizes Rhaponticum species chemistry, traditional uses, and research gaps across multiple conditions
Drug Pipeline Meta-analysis
Systematic review synthesizes Rhaponticum species chemistry, traditional uses, and research gaps across multiple conditions Ancient Herbs May Help Modern Health
This systematic review synthesizes data on Rhaponticum species, covering 24 documented species worldwide and their applications for conditio…
Imagine walking through a garden filled with wildflowers.
Frontiers Apr 24, 2026
Invasive aspergillosis after COVID-19 linked to higher 14-day mortality than after influenza
Rheumatology Cohort
Invasive aspergillosis after COVID-19 linked to higher 14-day mortality than after influenza Why COVID-19 Makes Lung Fungus Deadlier
This retrospective cohort study of 45 IAPA and 82 CAPA patients found that 14-day mortality risk was 4.92 times higher for CAPA versus IAPA.
Imagine a patient fighting a severe lung infection.
Frontiers Apr 24, 2026
Infection status associated with hypoxemia and death rates varying by virus type in a large US cohort
Geriatrics & Aging Cohort
Infection status associated with hypoxemia and death rates varying by virus type in a large US cohort Triple Virus Infections Rarer Than Feared — Here’s the Real Risk
This cohort study of 835,987 triple-tested patients in the US Veterans Health Administration examined associations between infection status …
It’s winter. Your throat is scratchy. Your chest feels tight.
Frontiers Apr 23, 2026
Narrative review outlines VLP engineering strategies for broadly protective vaccines against multiple viral pathogens
Infectious Disease Sys. Review
Narrative review outlines VLP engineering strategies for broadly protective vaccines against multiple viral pathogens New Vaccine Map Helps Pick Best Tools
This narrative review examines virus-like particle (VLP) engineering strategies, including genetic fusion, modular conjugation, and nucleic …
Imagine trying to fix a leaky roof with every tool in the shed.
Frontiers Apr 23, 2026

Research across Orthomyxoviridae Infections

Related studies from across the Orthomyxoviridae Infections family.

ACIP Issues Recommendations for Seasonal Influenza Prevention and Control with Vaccines
Allergy & Immunology
ACIP Issues Recommendations for Seasonal Influenza Prevention and Control with Vaccines What's the latest advice on flu shots this season?
The Advisory Committee on Immunization Practices (ACIP) has published recommendations for the prevention and control of seasonal influenza u…
U.S. health officials released updated flu shot advice for the 2023-24 season, emphasizing vaccination as the core way to prevent and contro…
CDC Apr 4, 2026
ACIP Issues Recommendations for Seasonal Influenza Vaccine Use in 2022-23
Allergy & Immunology
ACIP Issues Recommendations for Seasonal Influenza Vaccine Use in 2022-23 What flu shot should you get this year? Here are the official recommendations
The Advisory Committee on Immunization Practices (ACIP) has published its annual recommendations for seasonal influenza vaccine use in the U…
The 2022-23 flu season has official vaccine recommendations from experts to help you get the best protection against circulating strains.
CDC Apr 4, 2026
CDC Issues Recommendations for Seasonal Influenza Prevention and Control with Vaccines
Allergy & Immunology
CDC Issues Recommendations for Seasonal Influenza Prevention and Control with Vaccines Health officials release updated recommendations for seasonal flu vaccines
The CDC has published recommendations and reports for the prevention and control of seasonal influenza with vaccines in the United States.
CDC releases updated flu vaccine guidance for the upcoming season, advising doctors and the public on who should get vaccinated and when.
CDC Apr 3, 2026

Questions about Influenza

Does taking the flu shot with RSV vaccine work well for seniors?

Yes, coadministering the high-dose flu shot and RSV vaccine is safe and works well for seniors, though the RSV immune response may be slightly lower.

Full answer →
What new ways are scientists using to make flu vaccines protect more?

Scientists are improving flu vaccines by combining them with other vaccines, using intranasal delivery, and engineering virus-like particles to trigger broader immune responses.

Full answer →

All Influenza Articles