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Opioid prescribing in pregnancy increased in Catalonia from 2011 to 2020Pregnant women getting more pain pills in Spain

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Key Takeaway
Consider that opioid prescribing in pregnancy increased in Catalonia, with most exposures involving weak opioids.

This retrospective drug-utilization cohort study used the SIDIAP database, covering 75% of the Catalan population, to analyze opioid prescribing patterns among 41,398 pregnancies in women aged 12–50 years from April 2011 to March 2020. The primary exposure was at least one opioid prescription during pregnancy, with pregnancies not exposed to opioids as the comparator.

The main result was that 998 out of 41,398 pregnancies (2.41%) involved opioid exposure. Opioid prescribing increased over the study period. Among exposed pregnancies, 96.39% involved weak opioids. In over one-third of cases, opioid exposure exceeded 30 days.

Safety and tolerability outcomes were not reported. The study did not report adverse events, serious adverse events, or discontinuations.

Key limitations include the observational design, which cannot establish causality, and the lack of reported p-values or confidence intervals. The study did not report pregnancy outcomes as a primary result.

The practice relevance underscores the need for pregnancy-specific pain management guidelines and stricter adherence to existing recommendations, based on these prescribing patterns.

  • Opioid prescriptions for pregnant women rose sharply after 2013.
  • Most patients received weak opioids like tramadol for non-cancer pain.
  • Many took these drugs for over a month, which experts worry about.

The Hidden Pain Problem

Imagine a woman in her second trimester. She has a bad back or a toothache. She goes to her doctor. She needs relief. But what if the medicine she gets could hurt her baby? This is the fear behind the new research.

Pain is common during pregnancy. Hormones change joints. Weight gain strains the back. Yet, finding safe pain relief is hard. Doctors often avoid strong painkillers because of fears for the fetus. This leaves a gap. Many women suffer in silence or take medicines that might not be fully safe.

This study looked at Catalonia, Spain. It checked records for nearly 42,000 pregnancies. The goal was simple: Are we giving too many pain pills? The answer is yes, and the trend is growing.

Prescriptions jumped up, especially after 2013. Most were for non-cancer pain. This means regular aches and pains, not terminal illness. The study found that weak opioids were used most often. However, the length of use is the real worry.

For years, doctors tried to avoid opioids in pregnancy. They preferred other options. But pain is real. Sometimes, nothing else works. Now, the pattern has changed.

But here's the twist. The study found that doctors often did not use other painkillers first. They skipped non-steroidal anti-inflammatory drugs (NSAIDs). They also let patients take opioids for very long times. This contradicts current safety guidelines.

Think of the baby's development like a delicate garden. Every chemical a mother takes is like rain or fertilizer. Too much of the wrong kind can damage the plants. Opioids cross the placenta. They reach the baby.

Long-term exposure is like leaving the garden door open all night. It invites problems. The study showed that over one-third of women took opioids for more than 30 days. Strong opioids were taken even longer. This creates a risk for the baby's brain and breathing system.

Researchers used a huge database called SIDIAP. It covers 75% of Catalonia's population. They looked at women aged 12 to 50. The data spanned from April 2011 to March 2020. They counted every opioid prescription during pregnancy. They also tracked how long the treatment lasted.

Out of 41,398 pregnancies, 998 involved opioid use. That is 2.41%. While this number seems small, the rate is rising. Tramadol was the most common drug. It is a weak opioid.

Here is the catch. Paracetamol (acetaminophen) was often used with opioids. This is good. But NSAIDs were rarely used alongside them. Guidelines suggest using NSAIDs first or with opioids. This study shows that is not happening often enough.

But there is a catch. This doesn't mean this treatment is available yet. The study highlights a gap between what doctors do and what they should do. Patients are getting exposed to risks they might not understand.

The researchers say we need new rules. Current guidelines are not being followed. They call for pregnancy-specific pain management plans. Doctors need to know exactly what is safe. They need to know how long a drug can be taken.

This fits into a bigger picture. Pain management is evolving. We want to help mothers without hurting babies. But we need data to prove what works. This study gives us that data. It shows we are moving in the wrong direction.

If you are pregnant or planning to be, talk to your doctor about pain. Ask if there are safer options. Do not assume all pain pills are the same. Weak opioids are not risk-free. Long-term use is the main concern.

You should not stop taking prescribed medicine without advice. But you can ask questions. Ask about the duration of treatment. Ask if other painkillers could work first. Your health and your baby's health are the priority.

This study has limits. It only looked at Catalonia. It did not include all of Spain. It also relied on prescription records. It did not know if patients took the pills exactly as prescribed. Some might have taken more than written.

What happens next? We need stricter adherence to guidelines. Doctors must follow safety rules more closely. New trials might test safer pain plans. We need more research on long-term effects.

Research takes time. We cannot rush to conclusions. But we must act now. The rise in prescriptions is clear. We must fix the gap between guidelines and practice. Only then can we ensure safety for every mother and baby.

Study Details

Study typeCohort
EvidenceLevel 3
PublishedApr 2026
View Original Abstract ↓
BackgroundThe increasing use of opioids during pregnancy and their potential adverse effects on fetal development have raised public health concerns. This study aimed to investigate the opioid prescribing patterns among pregnant women in Catalonia, Spain.Materials and MethodsA retrospective drug-utilization study was conducted using the Information System for Research in Primary Care (SIDIAP) database, covering 75% of the Catalan population. Pregnancies in women aged 12–50 years between April 2011 and March 2020 were included. Opioid exposure was defined as at least one opioid prescription during pregnancy and was estimated through prevalence and cumulative incidence in pregnancy episodes and by trimester. We also examined pregnancy outcomes, exposure duration, and the use of non-opioid analgesics prior and concomitant to opioid therapy.ResultsAmong 41,398 pregnancies, 998 (2.41%) were exposed to prescribed opioids. Opioid prescribing increased over time, particularly since 2013 and mainly for non-cancer pain. Most exposures involved weak opioids (96.39%), with tramadol being the most frequently prescribed. Paracetamol use before or during opioid treatment was common, while NSAID use was less frequent. In over one-third of cases, opioid exposure exceeded 30 days, with even longer durations for those exposed to strong opioids.ConclusionOur findings show a rise in opioid prescribing among pregnant women in Catalonia, primarily for non-cancer pain. Contradicting current guidelines, opioids were often prescribed without prior or concurrent NSAID use and with extended exposure durations. This underscores the need for pregnancy-specific pain management guidelines and stricter adherence to existing recommendations to minimize potential risks to the fetus.
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