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Home › Medications › tramadol

tramadol

4 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of tramadol

19 trials tracked of tramadol: 12 in phase 3 or 4 and 4 with published results. The most-cited published study has 54 citations.

19Trials tracked
12Phase 3 & 4
0Recruiting
4With published results
Phase distribution
Phase 4 6 Phase 3 6 Phase 2 3 Phase 1 4
  1. Phase 4 MAST Trial: Multi-modal Analgesic Strategies in Trauma Completed · 54 cited
  2. Phase 3 Tramadol Versus Placebo in the Management of Postoperative Pain Following Bunionectomy Completed · 14 cited
  3. Phase 4 OTC Naproxen and Acetaminophen Anti-Inflammatory Action in Dental Implant Patients Completed · 8 cited
  4. Phase 4 Tramadol Extended-Release (ER) for Posttraumatic Stress Disorder (PTSD) Completed · 4 cited
  5. Phase 4 Comparison of Metoprolol and Tramadol With Remifentanil in Endoscopic Sinus Surgery Completed
  6. Phase 4 The Effect of Anti-inflammatory Analgesics on Pain Following Hallux Valgus Surgery Completed
Show 13 more trials
  1. Phase 4 An Efficacy Study of Combination of Tramadol and Acetaminophen Tablets in the Treatment of Participants With Fibromyalgia Pain Completed
  2. Phase 3 Combined Behavioral and Analgesic Trial for Fibromyalgia Completed
  3. Phase 3 Evaluate Safety of Tramadol in the Management of Postoperative Pain Following Surgery Completed
  4. Phase 3 A Six Week Study Of The Pain Relieving Effects Of Celecoxib 200 Mg Twice Daily Compared To Tramadol 50 Mg Four Times Daily In Patients With Chronic Low Back Pain Completed
  5. Phase 3 A Comparative Study of JNS013 in Participants With Post-Tooth-Extraction Pain Completed
  6. Phase 3 Efficacy of Extended Release Tramadol for Treating Prescription Opioid Withdrawal Completed
  7. Phase 2 The Discriminative Effects of Tramadol in Humans Completed
  8. Phase 2 Analgesic Effect of Different Combinations of Dexketoprofen Trometamol With Tramadol Hydrochloride in a Model of Moderate to Severe Pain Completed
  9. Phase 2 Transdermal Buprenorphine for the Treatment of Radiation-Induced Mucositis Pain in Head and Neck Cancer Patients Completed
  10. Phase 1 A Dose Linearity Study of the Labopharm Formulation of Tramadol HCl/Contramid®, 100 mg, 200 mg and 300 mg After A Single Oral Administration In Fasting Condition, In Healthy Human Volunteers Completed
  11. Phase 1 A Study to Compare the Bioavailability of Two Tramadol Hydrochloride Tablet Products (50 mg and 200 mg, Respectively) at Steady-state Under Fasting Conditions Completed
  12. Phase 1 Study of Two Tramadol Contramid® OAD 300 mg Controlled-Release Tablets From Two Different Manufacturing Sites Following a 300 mg Dose in Healthy Subjects Under Fasting and Fed Conditions Completed
  13. Phase 1 A Study to Compare the Relative Bioavailability of Two 200 Mg Tramadol Hydrochloride Tablet Products Under Fasting Conditions Completed

Showing the 19 most-cited and recently-updated of 19 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Erector spinae plane block reduces morphine consumption and extends analgesia duration in breast cancer surgery
Oncology Meta-analysis
Erector spinae plane block reduces morphine consumption and extends analgesia duration in breast cancer surgery Nerve Block May Reduce Pain and Opioid Use in Breast Surgery
This meta-analysis evaluates the efficacy of uni-level erector spinae plane block (ESPB) for pain management in breast cancer surgery patien…
A specific nerve block may help reduce pain and lower the amount of opioids needed for patients recovering from breast cancer surgery.
Oct 14, 2026
Preoperative pregabalin 150 mg cuts pain and opioid use after laparoscopic cholecystectomy
Drug Pipeline Meta-analysis
Preoperative pregabalin 150 mg cuts pain and opioid use after laparoscopic cholecystectomy Pregabalin May Reduce Pain After Gallbladder Surgery
This meta-analysis of randomized trials found that a single 150 mg preoperative dose of pregabalin significantly reduced 24-hour postoperati…
A single dose of pregabalin before surgery may lower pain scores and reduce the need for opioid medications after gallbladder removal.
medRxiv Aug 23, 2026
Dexmedetomidine added to TAP block reduces tramadol consumption and pain scores during cesarean section
Anesthesiology & Pain Medicine Meta-analysis
Dexmedetomidine added to TAP block reduces tramadol consumption and pain scores during cesarean section Dexmedetomidine helps manage pain for women during C-sections
This meta-analysis of 799 women undergoing spinal anesthesia for cesarean section found that dexmedetomidine in a TAP block significantly re…
Adding dexmedetomidine to local anesthesia can delay the need for pain medicine and lower reported pain scores for women undergoing C-sectio…
Aug 4, 2026
Opioid prescribing in pregnancy increased in Catalonia from 2011 to 2020
Drug Pipeline Cohort
Opioid prescribing in pregnancy increased in Catalonia from 2011 to 2020 Pregnant women getting more pain pills in Spain
This retrospective drug-utilization study of 41,398 pregnancies in Catalonia found that 2.41% involved opioid exposure, with prescribing inc…
A new study shows doctors in Spain are prescribing pain pills to pregnant women more often, but current rules might not be protecting babies…
Frontiers Apr 22, 2026