Early Physical Interventions Reduce ICU-Acquired Weakness Risk

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BMJ evidence-based medicine Published May 28, 2026 Medically reviewed May 28, 2026 Study authors: Chang Kai-Mei, Tu Yu-Kang, Wu Chia-Rung, Peters Kath, Ramjan Lucie, Hou Wen-Hsuan, Hou Sen-Kuang, Ph… PubMed ↗ DOI ↗ By Dr. Lars van Dijk, PhD · Surgical, Procedural & Diagnostic

Key Takeaway

Early mobilisation and NMES significantly reduce ICU-acquired weakness in critically ill patients.

A systematic review and component network meta-analysis of 63 randomized controlled trials evaluated the effectiveness of early physical interventions for preventing intensive care unit-acquired weakness (ICUAW) in critically ill patients aged 18 years or older who were mechanically ventilated or within 7 days of ICU admission.

Compared to routine care, systematic early mobilisation (SEM) combined with neuromuscular electrical stimulation (NMES) showed the largest reduction in ICUAW incidence (odds ratio [OR] 0.03, 95% CI 0.00–0.42), followed by SEM alone (OR 0.09, 95% CI 0.01–0.97) and NMES alone (OR 0.12, 95% CI 0.03–0.44). Component network meta-analysis confirmed that both SEM (OR 0.14, 95% CI 0.02–0.83) and NMES (OR 0.22, 95% CI 0.09–0.52) effectively mitigated ICUAW.

These findings suggest that implementing early mobilisation protocols with structured patient assessments or applying NMES to specific muscle groups can significantly reduce ICUAW risk. The analysis did not report adverse events, limitations, or funding sources, and certainty of evidence was not explicitly assessed.

Healthcare providers in ICUs should consider integrating these interventions into routine care to improve clinical outcomes for critically ill patients. However, causal inference is limited by the network meta-analysis design, and results may not generalize beyond the included RCT populations.

Study Details

Study typeMeta analysis

EvidenceLevel 1

Follow-up216.0 mo

PublishedMay 2026

PMID41083191

View Original Abstract ↓

OBJECTIVE: To compare the effects of early physical interventions on the prevention of intensive care unit-acquired weakness (ICUAW) and the improvement of relevant clinical outcomes in patients with critical illness. METHODS: We systematically searched the Web of Science, PubMed, Embase and the Cochrane Central Register of Controlled Trials from their inception until 20 August 2024, to identify randomised controlled trials (RCTs) enrolling patients ≥18 years old and implementing early physical intervention that commenced at any time point during mechanical ventilation (MV) use or within 7 days after intensive care unit (ICU) admission for review. We synthesised data using a random-effects model and analysed through network meta-analysis (NMA) and component network meta-analysis (CNMA). MAIN OUTCOME MEASURES: Primary outcome is the incidence of ICUAW. Secondary outcomes included Medical Research Council sum score, length of stay in the ICU or hospital, duration of MV and mortality rates in the ICU or hospital. RESULTS: Our analyses included 63 RCTs involving 24 treatments and eight components. The NMA results revealed systematic early mobilisation (SEM) combined with neuromuscular electrical stimulation (NMES), SEM alone and NMES alone may lead to a moderate to large reduction in the incidence of ICUAW (odds ratios [ORs]=0.03, 0.09 and 0.12, 95% confidence intervals [CIs]=0.00 to 0.42, 0.01 to 0.97 and 0.03 to 0.44, respectively) and improved relevant clinical outcomes compared with routine care. The CNMA results further indicated that SEM (OR=0.14, 95% CI=0.02 to 0.83) and NMES (OR=0.22, 95% CI=0.09 to 0.52) effectively mitigated the ICUAW incidence. CONCLUSIONS: SEM and NMES are optimal interventions for preventing ICUAW. Healthcare providers in ICUs should implement early mobilisation with structured protocols and patient assessments or apply NMES to specific muscle groups to prevent ICUAW in critically ill patients and improve relevant clinical outcomes. PROSPERO REGISTRATION NUMBER: CRD42024581173.