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Nurse-led music intervention shows preliminary benefit for cognitive impairment in colorectal cancer patientsCan listening to your favorite music help clear cancer treatment brain fog?

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Key Takeaway
Consider preliminary evidence for nurse-led music therapy in CRCI; await confirmatory trials.

This pilot randomized controlled trial evaluated a 9-week, nurse-led, individualized music-listening intervention for cancer-related cognitive impairment in 70 colorectal cancer patients (61 completed). The intervention was personalized using music preference questionnaires and interviews, while the control group received routine care. The primary outcome was perceived cognitive impairments (PCI).

At both 6 and 9 weeks, the intervention group showed significant improvement in PCI compared to the control group (P < 0.001 at both time points), with large effect sizes (Cohen's d = 1.143 at 6 weeks, 1.382 at 9 weeks). Significant time × group interactions were also found for perceived cognitive abilities, depression, sleep quality, and self-efficacy (P values ranging from <0.001 to 0.007). Results for several secondary cognitive outcomes (immediate memory, delayed memory, attention, executive function) were not explicitly reported in the provided data.

Safety and tolerability were not reported. Nine patients did not complete the study. The study had several limitations: it was a pilot study with a small sample size, short-term follow-up (9 weeks), and preliminary efficacy findings. Funding and conflicts of interest were not reported.

This nurse-led approach may represent a practical, low-cost supportive strategy in oncology nursing. However, the evidence remains preliminary, and the intervention requires validation in larger, definitive trials with longer follow-up before broader clinical implementation can be recommended.

Many people who've had cancer treatment know the frustrating mental fog that can linger—trouble remembering, focusing, or thinking clearly. A new, small study asked if something as simple as listening to music could help. Researchers worked with 61 colorectal cancer patients who were dealing with this cognitive impairment. For nine weeks, one group listened to music they personally loved, chosen with a nurse's guidance, while another group received routine care.

The results were striking for how people felt. Those in the music group reported significantly fewer problems with their memory and thinking at six and nine weeks. They also felt better about their cognitive abilities, had less depression, slept better, and felt more confident in managing their health. The study didn't report whether there were any negative side effects from the listening program.

It's important to understand what this study does and doesn't tell us. This was a pilot study, which means it's a first look to see if the idea is worth pursuing in a bigger trial. The group was small, and we only followed them for the length of the intervention. While patients felt much better, the study abstract didn't share clear results from the actual tests of memory, attention, or executive function. So, we know the music helped how they felt, but we don't yet have the full picture on objective cognitive performance. The nurse-led approach is a practical idea, but we need larger, longer studies to confirm these promising early findings.

What this means for you:
Personalized music listening improved how cancer patients felt about their 'chemo brain' in a small, preliminary study.

Study Details

Study typeRct
EvidenceLevel 2
Follow-up2.1 mo
PublishedApr 2026
View Original Abstract ↓
PURPOSE: Cancer-related cognitive impairment (CRCI) significantly affects colorectal cancer patients. Individualized music listening offers a theoretically grounded approach that may alleviate cognitive symptoms, though its efficacy in colorectal cancer patients with CRCI remains unexplored. This pilot study aimed to evaluate the feasibility and preliminary efficacy of a nurse-led, individualized music-listening intervention, designed using the Capacity, Opportunity, Motivation-Behavior and Behavior Change Wheel models, for improving cognitive function in colorectal cancer patients with CRCI. METHODS: Seventy patients were block-randomized to receive either a 9-week intervention or routine care. The intervention was personalized using music preference questionnaires and interviews to tailor playlists and listening schedules. The primary outcome was perceived cognitive impairments (PCI), while secondary outcomes included perceived cognitive abilities, immediate memory, delayed memory, attention, executive function, anxiety, depression, sleep quality, fatigue, and self-efficacy. Data were analyzed using linear mixed-effects models. RESULTS: Sixty-one participants completed the study. Significant time × group interactions were found for PCI, perceived cognitive abilities, depression, sleep quality, and self-efficacy (P < 0.001, P < 0.001, P < 0.001, P = 0.001, P = 0.007). The intervention group showed significant improvements in PCI at 6 and 9 weeks (Cohen's d = 1.143 and 1.382, respectively; both P < 0.001). Positive trends were observed for depression and self-efficacy. CONCLUSIONS: This study demonstrated feasibility and preliminary efficacy in improving cognitive impairment in this population. This nurse-led approach may serve as a practical, low-cost strategy to support cognitive health in oncology nursing.
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